Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PGRMC1
  • Mouse genes Pgrmc1
  • Rat genes Pgrmc1
  • Zfish genes pgrmc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pgrmc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0020037	heme binding	PGRMC1	IDA		Human	PMID:26988023
Molecular Function	GO:0020037	heme binding	PGRMC1	IDA		Human	PMID:27599036
Molecular Function	GO:0020037	heme binding	Pgrmc1	IDA		Mouse	MGI:MGI:6393146|PMID:31748741
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:P00181	Human	PMID:21081644
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:P16435	Human	PMID:21081644
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:P00533|UniProtKB:P05177|UniProtKB:P08684	Human	PMID:26988023
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:P22830	Human	PMID:27599036
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:O15173	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:O43681	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:O76071	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:P34910-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:P49069	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:Q13323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:Q8N6L0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:Q8NBJ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:Q8NES8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:Q9H6E4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:Q9NQZ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PGRMC1	IPI	UniProtKB:Q9UJ90	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pgrmc1	IPI	UniProtKB:Q80UU9	Mouse	MGI:MGI:6393146|PMID:31748741
Molecular Function	GO:0042803	protein homodimerization activity	PGRMC1	IDA		Human	PMID:26988023
Cellular Component	GO:0044297	cell body	Pgrmc1	IDA		Rat	PMID:25390692|RGD:12859076
Cellular Component	GO:0016020	membrane	PGRMC1	HDA		Human	PMID:19946888
Cellular Component	GO:0005741	mitochondrial outer membrane	Pgrmc1	IDA		Mouse	MGI:MGI:5810216|PMID:27599036
Cellular Component	GO:0043005	neuron projection	Pgrmc1	IDA		Rat	PMID:25390692|RGD:12859076
Cellular Component	GO:0043025	neuronal cell body	Pgrmc1	IDA		Rat	PMID:25390692|RGD:12859076
Cellular Component	GO:0045202	synapse	Pgrmc1	IDA		Rat	PMID:25390692|RGD:12859076
Biological Process	GO:0008306	associative learning	Pgrmc1	IGI	ComplexPortal:CPX-1134	Rat	PMID:25390368|RGD:12910997
Biological Process	GO:0007411	axon guidance	Pgrmc1	IEP		Rat	PMID:10656251|RGD:727289
Biological Process	GO:0006783	heme biosynthetic process	PGRMC1	IDA		Human	PMID:27599036
Biological Process	GO:0007613	memory	Pgrmc1	IGI	ComplexPortal:CPX-1134	Rat	PMID:25390368|RGD:12910997
Biological Process	GO:0099563	modification of synaptic structure	Pgrmc1	IGI	ComplexPortal:CPX-1134	Rat	PMID:25390368|RGD:12910997
Biological Process	GO:1905809	negative regulation of synapse organization	Pgrmc1	IGI	ComplexPortal:CPX-1134	Rat	PMID:25390368|RGD:12910997
Biological Process	GO:0001556	oocyte maturation	pgrmc1	IMP	ZFIN:ZDB-GENO-201001-4	Zfish	PMID:31536721
Biological Process	GO:0001556	oocyte maturation	pgrmc1	IMP	ZFIN:ZDB-GENO-190214-5	Zfish	PMID:30319543
Biological Process	GO:0001541	ovarian follicle development	pgrmc1	IMP	ZFIN:ZDB-GENO-190214-5	Zfish	PMID:30319543
Biological Process	GO:0030728	ovulation	pgrmc1	IMP	ZFIN:ZDB-GENO-201001-4	Zfish	PMID:31536721
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	Pgrmc1	IMP		Rat	PMID:25390692|RGD:12859076
Biological Process	GO:1903538	regulation of meiotic cell cycle process involved in oocyte maturation	pgrmc1	IDA		Zfish	PMID:25720537
Biological Process	GO:0032570	response to progesterone	pgrmc1	IMP	ZFIN:ZDB-GENO-190214-5	Zfish	PMID:30319543

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern