Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PHF8
  • Mouse genes Phf8
  • Rat genes Phf8
  • Zfish genes phf8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Phf8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	PHF8	IDA		Human	PMID:20023638
Molecular Function	GO:0003682	chromatin binding	PHF8	IDA		Human	PMID:20622854
Molecular Function	GO:0032452	histone demethylase activity	PHF8	IDA		Human	PMID:19843542
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	PHF8	IDA		Human	PMID:20622853
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	PHF8	IDA		Human	PMID:20622854
Molecular Function	GO:0051864	histone H3K36 demethylase activity	PHF8	IDA		Human	PMID:20208542
Molecular Function	GO:0051864	histone H3K36 demethylase activity	PHF8	IDA		Human	PMID:20622853
Molecular Function	GO:0032454	histone H3K9 demethylase activity	PHF8	IDA		Human	PMID:20023638
Molecular Function	GO:0032454	histone H3K9 demethylase activity	PHF8	IDA		Human	PMID:20208542
Molecular Function	GO:0032454	histone H3K9 demethylase activity	PHF8	IDA		Human	PMID:20346720
Molecular Function	GO:0032454	histone H3K9 demethylase activity	PHF8	IDA		Human	PMID:20622853
Molecular Function	GO:0032454	histone H3K9 demethylase activity	PHF8	IDA		Human	PMID:20622854
Molecular Function	GO:0035575	histone H4K20 demethylase activity	PHF8	IDA		Human	PMID:20622853
Molecular Function	GO:0005506	iron ion binding	PHF8	IDA		Human	PMID:20023638
Molecular Function	GO:0035064	methylated histone binding	PHF8	IDA		Human	PMID:20023638
Molecular Function	GO:0035064	methylated histone binding	PHF8	IDA		Human	PMID:20208542
Molecular Function	GO:0035064	methylated histone binding	PHF8	IDA		Human	PMID:20346720
Molecular Function	GO:0035064	methylated histone binding	PHF8	IDA		Human	PMID:20622853
Molecular Function	GO:0035064	methylated histone binding	PHF8	IDA		Human	PMID:20622854
Molecular Function	GO:0035064	methylated histone binding	PHF8	IDA		Human	PMID:21029866
Molecular Function	GO:0005515	protein binding	PHF8	IPI	UniProtKB:P17480	Human	PMID:20208542
Molecular Function	GO:0005515	protein binding	PHF8	IPI	UniProtKB:Q9H9Y6	Human	PMID:20208542
Molecular Function	GO:0005515	protein binding	PHF8	IPI	UniProtKB:Q9Y462	Human	PMID:20346720
Molecular Function	GO:0005515	protein binding	PHF8	IPI	UniProtKB:O15047	Human	PMID:20622854
Molecular Function	GO:0005515	protein binding	PHF8	IPI	UniProtKB:P51610	Human	PMID:20622854
Molecular Function	GO:0005515	protein binding	PHF8	IPI	UniProtKB:Q01094	Human	PMID:20622854
Molecular Function	GO:0005515	protein binding	PHF8	IPI	UniProtKB:Q06330	Human	PMID:23022380
Molecular Function	GO:0005515	protein binding	PHF8	IPI	UniProtKB:O14978	Human	PMID:32051553
Molecular Function	GO:0005515	protein binding	PHF8	IPI	UniProtKB:Q96QS3	Human	PMID:34356104
Molecular Function	GO:0005515	protein binding	PHF8	IPI	UniProtKB:Q9Y462	Human	PMID:34356104
Molecular Function	GO:0008270	zinc ion binding	PHF8	IDA		Human	PMID:20023638
Cellular Component	GO:0031965	nuclear membrane	PHF8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	PHF8	IDA		Human	PMID:20208542
Cellular Component	GO:0005654	nucleoplasm	PHF8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PHF8	IDA		Human	PMID:19843542
Cellular Component	GO:0005634	nucleus	PHF8	IDA		Human	PMID:31691806
Biological Process	GO:0007420	brain development	phf8	IMP		Zfish	PMID:20622853|ZFIN:ZDB-PUB-100719-42
Biological Process	GO:0007420	brain development	phf8	IMP	ZFIN:ZDB-MRPHLNO-100802-1	Zfish	PMID:20622853
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	phf8	IMP	ZFIN:ZDB-MRPHLNO-100802-1	Zfish	PMID:20622853
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	phf8	IGI	ZFIN:ZDB-GENE-980526-26,ZFIN:ZDB-MRPHLNO-100802-1	Zfish	PMID:20622853
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	PHF8	IMP		Human	PMID:20622854
Biological Process	GO:0042472	inner ear morphogenesis	phf8	IMP	ZFIN:ZDB-MRPHLNO-100802-1	Zfish	PMID:33330448
Biological Process	GO:0061188	negative regulation of rDNA heterochromatin formation	PHF8	IDA		Human	PMID:20208542
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PHF8	IMP		Human	PMID:20346720
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PHF8	IDA		Human	PMID:20622853
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PHF8	IMP		Human	PMID:20622854
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	phf8	IMP		Zfish	PMID:20622853|ZFIN:ZDB-PUB-100719-42
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I	PHF8	IDA		Human	PMID:20208542
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PHF8	IDA		Human	PMID:31691806
Biological Process	GO:0048922	posterior lateral line neuromast deposition	phf8	IMP	ZFIN:ZDB-MRPHLNO-100802-1	Zfish	PMID:33330448
Biological Process	GO:0060319	primitive erythrocyte differentiation	phf8	IMP		Zfish	PMID:24240475
Biological Process	GO:0043523	regulation of neuron apoptotic process	phf8	IGI	ZFIN:ZDB-GENE-980526-26,ZFIN:ZDB-MRPHLNO-100802-1	Zfish	PMID:20622853

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern