Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PHLPP1
  • Mouse genes Phlpp1
  • Rat genes Phlpp1
  • Zfish genes phlpp1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Phlpp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PHLPP1	IPI	UniProtKB:P05771-2	Human	PMID:18162466
Molecular Function	GO:0005515	protein binding	PHLPP1	IPI	UniProtKB:Q14160	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	PHLPP1	IPI	UniProtKB:Q14160	Human	PMID:21701506
Molecular Function	GO:0005515	protein binding	PHLPP1	IPI	UniProtKB:Q80U72	Human	PMID:21701506
Molecular Function	GO:0005515	protein binding	PHLPP1	IPI	UniProtKB:O14745	Human	PMID:21804599
Molecular Function	GO:0005515	protein binding	PHLPP1	IPI	UniProtKB:O75317	Human	PMID:24145035
Molecular Function	GO:0005515	protein binding	PHLPP1	IPI	UniProtKB:Q8TAF3	Human	PMID:24145035
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	Phlpp1	IDA		Rat	PMID:20089132|RGD:5131540
Cellular Component	GO:0005737	cytoplasm	Phlpp1	IDA		Rat	PMID:20819118|RGD:8693633
Cellular Component	GO:0005737	cytoplasm	Phlpp1	IMP		Rat	PMID:20819118|RGD:8693633
Cellular Component	GO:0031965	nuclear membrane	Phlpp1	IDA		Rat	PMID:20819118|RGD:8693633
Cellular Component	GO:0005654	nucleoplasm	Phlpp1	IDA		Rat	PMID:20819118|RGD:8693633
Cellular Component	GO:0005886	plasma membrane	Phlpp1	IDA		Rat	PMID:20819118|RGD:8693633
Biological Process	GO:0007623	circadian rhythm	Phlpp1	IEP		Rat	PMID:10570941|RGD:633914
Biological Process	GO:0009649	entrainment of circadian clock	Phlpp1	IMP	MGI:MGI:4421807	Mouse	PMID:20080691
Biological Process	GO:0021766	hippocampus development	Phlpp1	IEP		Rat	PMID:20819118|RGD:8693633
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Phlpp1	IMP		Rat	PMID:20819118|RGD:8693633
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PHLPP1	IMP		Human	PMID:17386267
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Phlpp1	IMP		Rat	PMID:20819118|RGD:8693633
Biological Process	GO:0090038	negative regulation of protein kinase C signaling	Phlpp1	IMP		Rat	PMID:20819118|RGD:8693633
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Phlpp1	IMP		Rat	PMID:20819118|RGD:8693633
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	Phlpp1	IMP		Rat	PMID:20819118|RGD:8693633
Biological Process	GO:0006470	protein dephosphorylation	Phlpp1	IDA		Rat	PMID:20089132|RGD:5131540
Biological Process	GO:0006470	protein dephosphorylation	Phlpp1	IMP		Rat	PMID:20819118|RGD:8693633
Biological Process	GO:0042981	regulation of apoptotic process	PHLPP1	IDA		Human	PMID:20513427
Biological Process	GO:0046328	regulation of JNK cascade	PHLPP1	IDA		Human	PMID:17386267
Biological Process	GO:0043408	regulation of MAPK cascade	PHLPP1	IMP		Human	PMID:24530606
Biological Process	GO:1900744	regulation of p38MAPK cascade	PHLPP1	IDA		Human	PMID:17386267
Biological Process	GO:0001932	regulation of protein phosphorylation	Phlpp1	IMP		Rat	PMID:20819118|RGD:8693633
Biological Process	GO:0002667	regulation of T cell anergy	Phlpp1	IMP		Mouse	MGI:MGI:5013552|PMID:21498666

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern