Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PHOX2A
  • Mouse genes Phox2a
  • Rat genes Phox2a
  • Zfish genes phox2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Phox2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PHOX2A	IDA		Human	PMID:32094113
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Phox2a	IDA		Mouse	PMID:32094113
Molecular Function	GO:0005515	protein binding	PHOX2A	IPI	UniProtKB:O43464	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PHOX2A	IPI	UniProtKB:P41219	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PHOX2A	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Phox2a	IPI	PR:Q68FG0	Mouse	PMID:32094113
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Phox2a	IDA		Rat	PMID:8613746|RGD:631925
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	PHOX2A	IDA		Human	PMID:16280598
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PHOX2A	IDA		Human	PMID:28473536
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PHOX2A	IDA		Human	PMID:32094113
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	Phox2a	IDA		Mouse	PMID:32094113
Cellular Component	GO:0000785	chromatin	PHOX2A	IDA		Human	PMID:16280598
Cellular Component	GO:0005634	nucleus	Phox2a	IDA		Mouse	PMID:12023301
Cellular Component	GO:0005634	nucleus	Phox2a	IDA		Mouse	PMID:18076286
Biological Process	GO:0007568	aging	Phox2a	IEP		Rat	PMID:16033425|RGD:1579826
Biological Process	GO:0007420	brain development	phox2a	IGI	ZFIN:ZDB-GENE-011212-6	Zfish	PMID:14534139
Biological Process	GO:0021703	locus ceruleus development	Phox2a	IMP	MGI:MGI:2180328	Mouse	PMID:9115735
Biological Process	GO:0021703	locus ceruleus development	Phox2a	IMP	MGI:MGI:4438118	Mouse	PMID:21068058
Biological Process	GO:0021703	locus ceruleus development	phox2a	IMP	ZFIN:ZDB-GENO-140912-5	Zfish	PMID:10595509
Biological Process	GO:0021703	locus ceruleus development	phox2a	IMP	ZFIN:ZDB-GENO-140912-4	Zfish	PMID:10595509
Biological Process	GO:0030901	midbrain development	Phox2a	IMP		Mouse	PMID:21752929
Biological Process	GO:0048666	neuron development	phox2a	IMP	ZFIN:ZDB-GENO-980520-34	Zfish	PMID:10191060
Biological Process	GO:0048666	neuron development	phox2a	IMP	ZFIN:ZDB-GENO-980520-42	Zfish	PMID:10191060
Biological Process	GO:0048666	neuron development	phox2a	IMP	ZFIN:ZDB-GENO-980520-38	Zfish	PMID:10191060
Biological Process	GO:0003358	noradrenergic neuron development	phox2a	IMP	ZFIN:ZDB-GENO-140912-5	Zfish	PMID:10595509
Biological Process	GO:0003358	noradrenergic neuron development	phox2a	IMP	ZFIN:ZDB-GENO-140912-4	Zfish	PMID:10595509
Biological Process	GO:0003357	noradrenergic neuron differentiation	Phox2a	IMP	MGI:MGI:4438118	Mouse	PMID:21068058
Biological Process	GO:0021623	oculomotor nerve formation	Phox2a	IMP		Mouse	MGI:MGI:1098916|PMID:9374403
Biological Process	GO:0048486	parasympathetic nervous system development	Phox2a	IMP	MGI:MGI:2180328	Mouse	PMID:9115735
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PHOX2A	IDA		Human	PMID:16280598
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PHOX2A	IMP		Human	PMID:19573018
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Phox2a	IDA		Rat	PMID:8613746|RGD:631925
Biological Process	GO:0043576	regulation of respiratory gaseous exchange	Phox2a	IMP	MGI:MGI:2180328	Mouse	PMID:17218061
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	PHOX2A	IDA		Human	PMID:32094113
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Phox2a	IDA		Mouse	PMID:32094113
Biological Process	GO:0021523	somatic motor neuron differentiation	Phox2a	IMP	MGI:MGI:3521825	Mouse	PMID:16319924
Biological Process	GO:0048485	sympathetic nervous system development	Phox2a	IMP	MGI:MGI:2180328	Mouse	PMID:9115735
Biological Process	GO:0021642	trochlear nerve formation	Phox2a	IMP		Mouse	MGI:MGI:1098916|PMID:9374403

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern