Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Phox2b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PHOX2B
- Mouse genes Phox2b
- Rat genes Phox2b
- Zfish genes phox2ba,phox2bb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Phox2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PHOX2B	IDA		Human	PMID:16144830
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PHOX2B	IDA		Human	PMID:32094113
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Phox2b	IDA		Mouse	PMID:32094113
Molecular Function	GO:0005515	protein binding	Phox2b	IPI	PR:Q68FG0	Mouse	PMID:32094113
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	PHOX2B	IDA		Human	PMID:16144830
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	PHOX2B	IDA		Human	PMID:16280598
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PHOX2B	IDA		Human	PMID:28473536
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PHOX2B	IDA		Human	PMID:32094113
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	Phox2b	IDA		Mouse	PMID:32094113
Cellular Component	GO:0000785	chromatin	PHOX2B	IDA		Human	PMID:16280598
Cellular Component	GO:0005737	cytoplasm	Phox2b	IDA		Rat	PMID:18620340\|RGD:152025256
Cellular Component	GO:0005654	nucleoplasm	PHOX2B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Phox2b	IDA		Mouse	PMID:9758704
Cellular Component	GO:0005634	nucleus	Phox2b	IDA		Mouse	PMID:16854219
Cellular Component	GO:0005634	nucleus	Phox2b	IDA		Mouse	PMID:10536054
Cellular Component	GO:0005634	nucleus	Phox2b	IDA		Rat	PMID:17559094\|RGD:12910742
Cellular Component	GO:0005634	nucleus	Phox2b	IDA		Rat	PMID:18620340\|RGD:152025256
Cellular Component	GO:0005634	nucleus	Phox2b	IDA		Rat	PMID:19036978\|RGD:152025257
Cellular Component	GO:0005634	nucleus	Phox2b	IDA		Rat	PMID:24286756\|RGD:151708736
Biological Process	GO:0048483	autonomic nervous system development	PHOX2B	IMP		Human	PMID:12640453
Biological Process	GO:0007409	axonogenesis	phox2bb	IMP	ZFIN:ZDB-MRPHLNO-130820-9	Zfish	PMID:34048688
Biological Process	GO:0003360	brainstem development	PHOX2B	IEP		Human	PMID:12640453
Biological Process	GO:0048468	cell development	Phox2b	IMP	MGI:MGI:1926861	Mouse	PMID:15733675
Biological Process	GO:0021533	cell differentiation in hindbrain	Phox2b	IMP	MGI:MGI:1926861	Mouse	PMID:17922007
Biological Process	GO:0008283	cell population proliferation	Phox2b	IMP	MGI:MGI:1926861	Mouse	PMID:18506029
Biological Process	GO:0071773	cellular response to BMP stimulus	Phox2b	IDA		Mouse	PMID:19793887
Biological Process	GO:0071244	cellular response to carbon dioxide	Phox2b	IEP		Rat	PMID:19036978\|RGD:152025257
Biological Process	GO:0071542	dopaminergic neuron differentiation	Phox2b	IMP		Mouse	MGI:MGI:1337891\|PMID:10360575
Biological Process	GO:0048894	efferent axon development in a lateral line nerve	Phox2b	IMP	MGI:MGI:1926861	Mouse	PMID:12885554
Biological Process	GO:0048484	enteric nervous system development	PHOX2B	IEP		Human	PMID:12640453
Biological Process	GO:0048484	enteric nervous system development	Phox2b	IMP		Mouse	MGI:MGI:1337891\|PMID:10360575
Biological Process	GO:0048484	enteric nervous system development	phox2bb	IMP	ZFIN:ZDB-MRPHLNO-050601-1	Zfish	PMID:15817223
Biological Process	GO:0048484	enteric nervous system development	phox2bb	IMP	ZFIN:ZDB-MRPHLNO-050601-2	Zfish	PMID:15817223
Biological Process	GO:0010001	glial cell differentiation	Phox2b	IMP	MGI:MGI:1926861	Mouse	PMID:18506029
Biological Process	GO:0021934	hindbrain tangential cell migration	Phox2b	IMP	MGI:MGI:4418265	Mouse	PMID:21068058
Biological Process	GO:0048839	inner ear development	Phox2b	IMP	MGI:MGI:1926861	Mouse	PMID:12885554
Biological Process	GO:0021723	medullary reticular formation development	Phox2b	IEP		Mouse	MGI:MGI:1098916\|PMID:9374403
Biological Process	GO:0051899	membrane depolarization	Phox2b	IEP		Rat	PMID:19036978\|RGD:152025257
Biological Process	GO:0097475	motor neuron migration	Phox2b	IMP	MGI:MGI:3521828	Mouse	PMID:16319924
Biological Process	GO:0045665	negative regulation of neuron differentiation	Phox2b	IGI	MGI:MGI:1100882	Mouse	PMID:17922007
Biological Process	GO:1904691	negative regulation of type B pancreatic cell proliferation	Phox2b	IMP	MGI:MGI:1926861	Mouse	PMID:18506029
Biological Process	GO:1901166	neural crest cell migration involved in autonomic nervous system development	Phox2b	IMP		Mouse	MGI:MGI:1337891\|PMID:10360575
Biological Process	GO:0030182	neuron differentiation	Phox2b	IMP	MGI:MGI:1926861	Mouse	PMID:18506029
Biological Process	GO:0030182	neuron differentiation	Phox2b	IGI	MGI:MGI:1100882	Mouse	PMID:17922007
Biological Process	GO:0030182	neuron differentiation	Phox2b	IMP	MGI:MGI:1926861	Mouse	PMID:17922007
Biological Process	GO:0003358	noradrenergic neuron development	Phox2b	IMP		Mouse	MGI:MGI:3772428\|PMID:18094025
Biological Process	GO:0003357	noradrenergic neuron differentiation	Phox2b	IMP		Mouse	MGI:MGI:1337891\|PMID:10360575
Biological Process	GO:0003357	noradrenergic neuron differentiation	Phox2b	IMP	MGI:MGI:4418265	Mouse	PMID:21068058
Biological Process	GO:0048486	parasympathetic nervous system development	Phox2b	IMP		Mouse	MGI:MGI:1337891\|PMID:10360575
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Phox2b	IMP		Mouse	MGI:MGI:6162404\|PMID:21977017
Biological Process	GO:0045666	positive regulation of neuron differentiation	Phox2b	IGI	MGI:MGI:1100882	Mouse	PMID:17922007
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PHOX2B	IDA		Human	PMID:16144830
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PHOX2B	IDA		Human	PMID:16280598
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PHOX2B	IMP		Human	PMID:19573018
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Phox2b	IDA		Mouse	MGI:MGI:1340730\|PMID:10395798
Biological Process	GO:0010468	regulation of gene expression	Phox2b	IMP		Mouse	MGI:MGI:3772428\|PMID:18094025
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	Phox2b	IMP		Mouse	MGI:MGI:4418003\|PMID:19940179
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	PHOX2B	IDA		Human	PMID:32094113
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Phox2b	IDA		Mouse	PMID:32094113
Biological Process	GO:0060541	respiratory system development	Phox2b	IMP		Mouse	MGI:MGI:4418003\|PMID:19940179
Biological Process	GO:0014823	response to activity	Phox2b	IEP		Rat	PMID:24286756\|RGD:151708736
Biological Process	GO:0061452	retrotrapezoid nucleus neuron differentiation	Phox2b	IMP		Mouse	MGI:MGI:4418003\|PMID:19940179
Biological Process	GO:0035914	skeletal muscle cell differentiation	Phox2b	IMP		Mouse	PMID:22147266
Biological Process	GO:0061549	sympathetic ganglion development	Phox2b	IMP		Mouse	MGI:MGI:3772428\|PMID:18094025
Biological Process	GO:0061549	sympathetic ganglion development	phox2bb	IGI	ZFIN:ZDB-MRPHLNO-050308-13,ZFIN:ZDB-MRPHLNO-130820-9	Zfish	PMID:23754957
Biological Process	GO:0061549	sympathetic ganglion development	phox2bb	IMP	ZFIN:ZDB-MRPHLNO-130820-9	Zfish	PMID:23754957
Biological Process	GO:0048485	sympathetic nervous system development	Phox2b	IMP		Mouse	MGI:MGI:1337891\|PMID:10360575
Biological Process	GO:0044342	type B pancreatic cell proliferation	Phox2b	IMP	MGI:MGI:1926861	Mouse	PMID:18506029

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.