Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIAS4
  • Mouse genes Pias4
  • Rat genes Pias4
  • Zfish genes pias4a,pias4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pias4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Pias4	IDA		Mouse	PMID:11731474
Molecular Function	GO:0140678	molecular function inhibitor activity	PIAS4	IDA		Human	PMID:32832608
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P04637	Human	PMID:11388671
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:O75528	Human	PMID:15383276
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P42858	Human	PMID:15383276
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P61956	Human	PMID:15383276
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q04206	Human	PMID:17606919
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q2QGD7	Human	PMID:17696781
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P11474	Human	PMID:18063693
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P09874	Human	PMID:19779455
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q16665	Human	PMID:20661221
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q13330	Human	PMID:21965678
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P11474	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:O75626	Human	PMID:28842558
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:O00635	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q5T752	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q8NCN2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:F2Z2M7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:I6L9F6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:O00472	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:O43865	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:O60506-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:O60551	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:O60902-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:O75446	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:O95789-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P09017	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P12830	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P15976-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P57052	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:P80217-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q05BL1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q14457	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q14693	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q15078	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q6P1L5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q6ZP82	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q86W54-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q8IUI8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q8N5S9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q8TAK5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q8TD91-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q8WZ19	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q92615	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q96GM5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q96IK1-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q9BSJ5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q9NP98	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q9NX94	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q9UIH9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q9UKP3-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIAS4	IPI	UniProtKB:Q9Y4H4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Pias4	IPI	PR:P27782	Mouse	PMID:11731474
Molecular Function	GO:0005515	protein binding	Pias4	IPI	PR:P29037	Mouse	PMID:16522640
Molecular Function	GO:0005515	protein binding	Pias4	IPI	PR:Q04207	Mouse	PMID:20054338
Molecular Function	GO:0005515	protein binding	Pias4	IPI	RGD:731666	Rat	PMID:16144832|RGD:2303113
Molecular Function	GO:0061665	SUMO ligase activity	PIAS4	IDA		Human	PMID:18579533
Molecular Function	GO:0061665	SUMO ligase activity	PIAS4	IDA		Human	PMID:32832608
Molecular Function	GO:0061665	SUMO ligase activity	PIAS4	IDA		Human	PMID:35013556
Molecular Function	GO:0061665	SUMO ligase activity	Pias4	IDA		Mouse	MGI:MGI:4887534|PMID:19955185
Molecular Function	GO:0019789	SUMO transferase activity	PIAS4	EXP		Human	PMID:11731474
Molecular Function	GO:0019789	SUMO transferase activity	PIAS4	EXP		Human	PMID:19041634
Molecular Function	GO:0019789	SUMO transferase activity	PIAS4	EXP		Human	PMID:21965678
Molecular Function	GO:0019789	SUMO transferase activity	PIAS4	IMP		Human	PMID:22508508
Molecular Function	GO:0019789	SUMO transferase activity	Pias4	IDA		Mouse	PMID:11731474
Molecular Function	GO:0003714	transcription corepressor activity	Pias4	IDA		Mouse	PMID:11731474
Molecular Function	GO:0031625	ubiquitin protein ligase binding	PIAS4	IPI	UniProtKB:Q13049	Human	PMID:16816390
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Pias4	IPI	UniProtKB:Q8CH72	Mouse	MGI:MGI:5009403|PMID:16816390
Cellular Component	GO:0005737	cytoplasm	PIAS4	IDA		Human	PMID:16816390
Cellular Component	GO:0016363	nuclear matrix	Pias4	IDA		Mouse	PMID:11731474
Cellular Component	GO:0005654	nucleoplasm	Pias4	IDA		Mouse	PMID:16162816
Cellular Component	GO:0005634	nucleus	PIAS4	IDA		Human	PMID:11248056
Cellular Component	GO:0005634	nucleus	PIAS4	IDA		Human	PMID:16816390
Cellular Component	GO:0005634	nucleus	Pias4	IDA		Mouse	MGI:MGI:2154657|PMID:11731474
Cellular Component	GO:0005634	nucleus	pias4a	IDA		Zfish	PMID:22345667
Cellular Component	GO:1990234	transferase complex	Pias4	IDA		Mouse	MGI:MGI:4887534|PMID:19955185
Biological Process	GO:0007417	central nervous system development	Pias4	IEP		Mouse	MGI:MGI:1861161|PMID:10854042
Biological Process	GO:0001942	hair follicle development	Pias4	IEP		Mouse	MGI:MGI:1861161|PMID:10854042
Biological Process	GO:0060887	limb epidermis development	Pias4	IEP		Mouse	MGI:MGI:1861161|PMID:10854042
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PIAS4	IDA		Human	PMID:11248056
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	Pias4	IDA		Mouse	MGI:MGI:5009403|PMID:16816390
Biological Process	GO:0120186	negative regulation of protein localization to chromatin	PIAS4	IDA		Human	PMID:35013556
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Pias4	IDA		Mouse	MGI:MGI:4887534|PMID:19955185
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Pias4	IDA		Mouse	PMID:11731474
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	Pias4	IMP		Mouse	PMID:20054338
Biological Process	GO:0032480	negative regulation of type I interferon production	pias4a	IMP	ZFIN:ZDB-MRPHLNO-120914-1	Zfish	PMID:22345667
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	pias4a	IMP	ZFIN:ZDB-MRPHLNO-120914-1	Zfish	PMID:22345667
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	PIAS4	IDA		Human	PMID:32832608
Biological Process	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	Pias4	IDA		Mouse	PMID:16816390
Biological Process	GO:1902174	positive regulation of keratinocyte apoptotic process	Pias4	IDA		Mouse	MGI:MGI:5009403|PMID:16816390
Biological Process	GO:0033235	positive regulation of protein sumoylation	PIAS4	IDA		Human	PMID:17696781
Biological Process	GO:0033235	positive regulation of protein sumoylation	PIAS4	IDA		Human	PMID:21965678
Biological Process	GO:0016925	protein sumoylation	PIAS4	IDA		Human	PMID:18579533
Biological Process	GO:0016925	protein sumoylation	PIAS4	IMP		Human	PMID:22508508
Biological Process	GO:0016925	protein sumoylation	Pias4	IDA		Mouse	MGI:MGI:4887534|PMID:19955185
Biological Process	GO:0016925	protein sumoylation	Pias4	IDA		Mouse	PMID:11731474

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern