Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIEZO1
  • Mouse genes Piezo1
  • Rat genes Piezo1
  • Zfish genes piezo1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Piezo1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Piezo1	IPI	UniProtKB:E2JF22	Mouse	MGI:MGI:5925849|PMID:26390154
Molecular Function	GO:0042802	identical protein binding	Piezo1	IPI	UniProtKB:E2JF22	Mouse	MGI:MGI:5915369|PMID:22343900
Molecular Function	GO:0042802	identical protein binding	Piezo1	IPI	UniProtKB:E2JF22	Mouse	MGI:MGI:6294163|PMID:29469092
Molecular Function	GO:0042802	identical protein binding	Piezo1	IPI	UniProtKB:E2JF22	Mouse	MGI:MGI:6294209|PMID:29261642
Molecular Function	GO:0042802	identical protein binding	Piezo1	IPI	UniProtKB:E2JF22	Mouse	MGI:MGI:6106240|PMID:29176668
Molecular Function	GO:0140135	mechanosensitive monoatomic cation channel activity	Piezo1	IMP		Mouse	PMID:32142647
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	Piezo1	IDA		Mouse	PMID:20813920
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	piezo1	IDA		Zfish	PMID:29545531
Molecular Function	GO:0005261	monoatomic cation channel activity	Piezo1	IMP		Mouse	MGI:MGI:4833892|PMID:20813920
Molecular Function	GO:0005261	monoatomic cation channel activity	Piezo1	IDA		Mouse	PMID:20813920
Molecular Function	GO:0005515	protein binding	PIEZO1	IPI	UniProtKB:P04155	Human	PMID:24798994
Molecular Function	GO:0005515	protein binding	Piezo1	IPI	UniProtKB:O55143	Mouse	MGI:MGI:6106240|PMID:29176668
Molecular Function	GO:0005515	protein binding	Piezo1	IPI	UniProtKB:P16615-1	Mouse	MGI:MGI:6106240|PMID:29176668
Molecular Function	GO:0005515	protein binding	Piezo1	IPI	UniProtKB:O35245	Mouse	MGI:MGI:5613452|PMID:24157948
Molecular Function	GO:0022832	voltage-gated channel activity	piezo1	IDA		Zfish	PMID:29545531
Cellular Component	GO:0005783	endoplasmic reticulum	PIEZO1	IDA		Human	PMID:20016066
Cellular Component	GO:0005886	plasma membrane	Piezo1	IDA		Mouse	PMID:20813920
Biological Process	GO:0006884	cell volume homeostasis	piezo1	IMP	ZFIN:ZDB-MRPHLNO-140227-1	Zfish	PMID:23872304
Biological Process	GO:0050982	detection of mechanical stimulus	Piezo1	IMP		Mouse	PMID:20813920
Biological Process	GO:0010481	epidermal cell division	piezo1	IMP	ZFIN:ZDB-CRISPR-170908-2	Zfish	PMID:28199303
Biological Process	GO:0034101	erythrocyte homeostasis	piezo1	IMP	ZFIN:ZDB-MRPHLNO-140227-1	Zfish	PMID:23872304
Biological Process	GO:0034101	erythrocyte homeostasis	piezo1	IMP	ZFIN:ZDB-MRPHLNO-140227-1,ZFIN:ZDB-MRPHLNO-140227-2	Zfish	PMID:23872304
Biological Process	GO:0034101	erythrocyte homeostasis	piezo1	IMP	ZFIN:ZDB-MRPHLNO-140227-2	Zfish	PMID:23872304
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	piezo1	IMP	ZFIN:ZDB-MRPHLNO-120507-2	Zfish	PMID:22504183
Biological Process	GO:0098655	monoatomic cation transmembrane transport	Piezo1	IDA		Mouse	MGI:MGI:4833892|PMID:20813920
Biological Process	GO:0006812	monoatomic cation transport	Piezo1	IMP		Mouse	MGI:MGI:4833892|PMID:20813920
Biological Process	GO:0006812	monoatomic cation transport	Piezo1	IMP		Mouse	PMID:32142647
Biological Process	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin	PIEZO1	IMP		Human	PMID:20016066
Biological Process	GO:0033625	positive regulation of integrin activation	PIEZO1	IMP		Human	PMID:20016066
Biological Process	GO:0010831	positive regulation of myotube differentiation	PIEZO1	IMP		Human	PMID:29799007
Biological Process	GO:0010831	positive regulation of myotube differentiation	Piezo1	IMP		Mouse	MGI:MGI:6161090|PMID:29799007
Biological Process	GO:0010482	regulation of epidermal cell division	piezo1	IMP	ZFIN:ZDB-CRISPR-170908-2	Zfish	PMID:28199303
Biological Process	GO:0042391	regulation of membrane potential	Piezo1	IMP		Mouse	PMID:20813920
Biological Process	GO:0003173	ventriculo bulbo valve development	piezo1	IMP	ZFIN:ZDB-GENO-200714-10	Zfish	PMID:31524599

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern