Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIK3CD
  • Mouse genes Pik3cd
  • Rat genes Pik3cd
  • Zfish genes pik3cd
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pik3cd

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016301	kinase activity	PIK3CD	IDA		Human	PMID:25327288
Molecular Function	GO:0005515	protein binding	PIK3CD	IPI	UniProtKB:P27986	Human	PMID:21827948
Molecular Function	GO:0005515	protein binding	PIK3CD	IPI	UniProtKB:P01112	Human	PMID:22020336
Molecular Function	GO:0005515	protein binding	PIK3CD	IPI	UniProtKB:P27986	Human	PMID:22020336
Molecular Function	GO:0005515	protein binding	PIK3CD	IPI	UniProtKB:P27986	Human	PMID:24165795
Molecular Function	GO:0005515	protein binding	PIK3CD	IPI	UniProtKB:Q92569	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PIK3CD	IPI	UniProtKB:P27986	Human	PMID:31031754
Molecular Function	GO:0005515	protein binding	PIK3CD	IPI	UniProtKB:P27986-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PIK3CD	IPI	UniProtKB:Q92569	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pik3cd	IPI	UniProtKB:P26450	Mouse	MGI:MGI:5487514|PMID:22020336
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3CD	IPI		Human	PMID:28108251
Biological Process	GO:0042113	B cell activation	Pik3cd	IMP	MGI:MGI:2388047	Mouse	PMID:12235209
Biological Process	GO:0001782	B cell homeostasis	Pik3cd	IMP	MGI:MGI:2388047	Mouse	PMID:12235209
Biological Process	GO:0007166	cell surface receptor signaling pathway	Pik3cd	IMP	MGI:MGI:2388047	Mouse	PMID:12235209
Biological Process	GO:0050832	defense response to fungus	Pik3cd	IMP	MGI:MGI:2385596	Mouse	PMID:24009720
Biological Process	GO:0048872	homeostasis of number of cells	Pik3cd	IMP	MGI:MGI:2385596	Mouse	PMID:24009720
Biological Process	GO:0010629	negative regulation of gene expression	Pik3cd	IGI	UniProtKB:A0A0G2K344	Rat	PMID:28947594|RGD:13524616
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3CD	IMP		Human	PMID:25339672
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3CD	IGI	UniProtKB:P01133|UniProtKB:P09038|UniProtKB:P15692	Human	PMID:31915155
Biological Process	GO:0016310	phosphorylation	PIK3CD	IDA		Human	PMID:25327288
Biological Process	GO:0045766	positive regulation of angiogenesis	Pik3cd	IMP		Mouse	MGI:MGI:6405586|PMID:31915155
Biological Process	GO:0030335	positive regulation of cell migration	PIK3CD	IMP		Human	PMID:22079609
Biological Process	GO:0038089	positive regulation of cell migration by vascular endothelial growth factor signaling pathway	PIK3CD	IGI	UniProtKB:P15692	Human	PMID:31915155
Biological Process	GO:0010595	positive regulation of endothelial cell migration	PIK3CD	IGI	UniProtKB:P01133|UniProtKB:P09038	Human	PMID:31915155
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	PIK3CD	IGI	UniProtKB:P01133|UniProtKB:P09038|UniProtKB:P15692	Human	PMID:31915155
Biological Process	GO:1905278	positive regulation of epithelial tube formation	PIK3CD	IGI	UniProtKB:P01133|UniProtKB:P09038|UniProtKB:P15692	Human	PMID:31915155
Biological Process	GO:0010628	positive regulation of gene expression	PIK3CD	IMP		Human	PMID:22079609
Biological Process	GO:0010628	positive regulation of gene expression	Pik3cd	IMP	MGI:MGI:2385596	Mouse	PMID:24009720
Biological Process	GO:0033031	positive regulation of neutrophil apoptotic process	PIK3CD	IMP		Human	PMID:25339672
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	PIK3CD	IGI	UniProtKB:P01133|UniProtKB:P09038|UniProtKB:P15692	Human	PMID:31915155
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Pik3cd	IMP		Mouse	MGI:MGI:6405586|PMID:31915155
Biological Process	GO:0048696	regulation of collateral sprouting in absence of injury	pik3cd	IMP	ZFIN:ZDB-MRPHLNO-140703-7	Zfish	PMID:24218155
Biological Process	GO:0048696	regulation of collateral sprouting in absence of injury	pik3cd	IGI	ZFIN:ZDB-MRPHLNO-140703-6,ZFIN:ZDB-MRPHLNO-140703-7	Zfish	PMID:24218155

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern