Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIK3CG
  • Mouse genes Pik3cg
  • Rat genes Pik3cg
  • Zfish genes pik3cg
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pik3cg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	PIK3CG	IDA		Human	PMID:11277933
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	PIK3CG	IDA		Human	PMID:16123124
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3cg	IDA		Mouse	MGI:MGI:1926661|PMID:11054537
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3cg	IDA		Rat	PMID:12882977|RGD:4144086
Molecular Function	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	PIK3CG	IDA		Human	PMID:16123124
Molecular Function	GO:0046875	ephrin receptor binding	PIK3CG	IPI	UniProtKB:O09127	Human	PMID:11416136
Molecular Function	GO:0042802	identical protein binding	PIK3CG	IPI	UniProtKB:P48736	Human	PMID:20562859
Molecular Function	GO:0042802	identical protein binding	PIK3CG	IPI	UniProtKB:P48736	Human	PMID:23824069
Molecular Function	GO:0016301	kinase activity	PIK3CG	IDA		Human	PMID:25327288
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PIK3CG	IDA		Human	PMID:12502714
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PIK3CG	IDA		Human	PMID:15135396
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PIK3CG	IDA		Human	PMID:16123124
Molecular Function	GO:0005515	protein binding	PIK3CG	IPI	UniProtKB:O02696	Human	PMID:12507995
Molecular Function	GO:0005515	protein binding	PIK3CG	IPI	UniProtKB:Q13370	Human	PMID:21393242
Molecular Function	GO:0005515	protein binding	PIK3CG	IPI	UniProtKB:P68404-2	Human	PMID:23824069
Molecular Function	GO:0005515	protein binding	PIK3CG	IPI	UniProtKB:Q3U6Q4	Human	PMID:23824069
Molecular Function	GO:0005515	protein binding	PIK3CG	IPI	UniProtKB:P0DOE7	Human	PMID:25556234
Molecular Function	GO:0005515	protein binding	PIK3CG	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Pik3cg	IPI	UniProtKB:Q3U6Q4	Mouse	MGI:MGI:5014454|PMID:21665146
Molecular Function	GO:0005515	protein binding	Pik3cg	IPI	UniProtKB:Q3U6Q4	Mouse	MGI:MGI:3574247|PMID:15797027
Molecular Function	GO:0005515	protein binding	Pik3cg	IPI	UniProtKB:Q3U6Q4	Mouse	MGI:MGI:5514086|PMID:23824069
Molecular Function	GO:0106310	protein serine kinase activity	PIK3CG	IDA		Human	PMID:12502714
Cellular Component	GO:0005737	cytoplasm	PIK3CG	IDA		Human	PMID:12507995
Cellular Component	GO:0005829	cytosol	PIK3CG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	PIK3CG	IDA		Human	PMID:12507995
Cellular Component	GO:0016020	membrane	PIK3CG	HDA		Human	PMID:19946888
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	Pik3cg	IDA		Rat	PMID:12882977|RGD:4144086
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3CG	EXP		Human	PMID:10358071
Cellular Component	GO:0005944	phosphatidylinositol 3-kinase complex, class IB	PIK3CG	IDA		Human	PMID:12507995
Cellular Component	GO:0005886	plasma membrane	PIK3CG	IDA		Human	GO_REF:0000052
Biological Process	GO:0071320	cellular response to cAMP	Pik3cg	IMP	MGI:MGI:1858012	Mouse	PMID:23008439
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	PIK3CG	EXP		Human	PMID:10358071
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	PIK3CG	IDA		Human	PMID:12507995
Biological Process	GO:0097284	hepatocyte apoptotic process	Pik3cg	IMP		Rat	PMID:20675006|RGD:6482714
Biological Process	GO:2000270	negative regulation of fibroblast apoptotic process	Pik3cg	IDA		Mouse	PMID:15192701
Biological Process	GO:0010897	negative regulation of triglyceride catabolic process	Pik3cg	IMP		Rat	PMID:21435395|RGD:6482711
Biological Process	GO:0030593	neutrophil chemotaxis	pik3cg	IMP	ZFIN:ZDB-MRPHLNO-110317-2	Zfish	PMID:20159593
Biological Process	GO:0030593	neutrophil chemotaxis	pik3cg	IMP	ZFIN:ZDB-MRPHLNO-110317-1	Zfish	PMID:20159593
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3CG	IDA		Human	PMID:12507995
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3CG	IMP		Human	PMID:18558630
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3CG	IMP		Human	PMID:21840392
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Pik3cg	IMP		Mouse	MGI:MGI:4461861|PMID:18558630
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	PIK3CG	IDA		Human	PMID:12502714
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	Pik3cg	IDA		Rat	PMID:12882977|RGD:4144086
Biological Process	GO:0016310	phosphorylation	PIK3CG	IDA		Human	PMID:25327288
Biological Process	GO:0002675	positive regulation of acute inflammatory response	Pik3cg	IMP		Rat	PMID:17526805|RGD:1642429
Biological Process	GO:0043085	positive regulation of catalytic activity	Pik3cg	IMP	MGI:MGI:1858012	Mouse	PMID:23008439
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Pik3cg	IMP		Rat	PMID:11266463|RGD:6482715
Biological Process	GO:0010595	positive regulation of endothelial cell migration	PIK3CG	IMP		Human	PMID:18558630
Biological Process	GO:0010595	positive regulation of endothelial cell migration	Pik3cg	IMP		Mouse	MGI:MGI:4461861|PMID:18558630
Biological Process	GO:0043406	positive regulation of MAP kinase activity	PIK3CG	IDA		Human	PMID:12507995
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	PIK3CG	IDA		Human	PMID:12507995
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	PIK3CG	IMP		Human	PMID:18558630
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	Pik3cg	IMP		Mouse	MGI:MGI:4461861|PMID:18558630
Biological Process	GO:0006468	protein phosphorylation	Pik3cg	IDA		Mouse	PMID:15192701
Biological Process	GO:0045765	regulation of angiogenesis	PIK3CG	IMP		Human	PMID:21840392
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	Pik3cg	IMP	MGI:MGI:1858012	Mouse	PMID:23008439
Biological Process	GO:0001932	regulation of protein phosphorylation	Pik3cg	IMP	MGI:MGI:1858012	Mouse	PMID:23008439
Biological Process	GO:0032252	secretory granule localization	Pik3cg	IMP		Rat	PMID:19549714|RGD:2324863
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	PIK3CG	IMP		Human	PMID:18558630
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	Pik3cg	IMP		Mouse	MGI:MGI:4461861|PMID:18558630

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern