Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIK3R2
  • Mouse genes Pik3r2
  • Rat genes Pik3r2
  • Zfish genes pik3r2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pik3r2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	Pik3r2	IPI	UniProtKB:P26450	Mouse	MGI:MGI:4442277|PMID:20348926
Molecular Function	GO:0001784	phosphotyrosine residue binding	PIK3R2	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P21860	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P03496	Human	PMID:16963558
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q82506	Human	PMID:16963558
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P22681	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P42336	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P42338	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P46108	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P62993	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P62993	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q96HT8	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P42336	Human	PMID:22402981
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P42338	Human	PMID:22402981
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P03496	Human	PMID:22810585
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q82506	Human	PMID:22810585
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q9UKC9	Human	PMID:23604317
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P03496	Human	PMID:23853584
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P21860	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P10275	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P42336	Human	PMID:25253337
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:O76015	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P19012	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P35900	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P36406	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q08379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q6NUQ1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q8WWB3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q96HT8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q9UKT9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P22681	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P42336	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P03496	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P42338	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:O76015	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q9UKT9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P46108	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P42338	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P42336	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P46108	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P04626	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P08069	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P10721	Human	PMID:7537096
Molecular Function	GO:0005515	protein binding	PIK3R2	IPI	UniProtKB:P08069	Human	PMID:7541045
Molecular Function	GO:0005515	protein binding	Pik3r2	IPI	UniProtKB:O88665|UniProtKB:Q9JK42	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Pik3r2	IPI	UniProtKB:O35426-2|UniProtKB:P26450	Mouse	MGI:MGI:4442277|PMID:20348926
Molecular Function	GO:0005515	protein binding	Pik3r2	IPI	UniProtKB:Q6PFX7|UniProtKB:Q8BM65	Mouse	MGI:MGI:5304984|PMID:21946561
Molecular Function	GO:0005515	protein binding	Pik3r2	IPI	PR:Q9JLY0	Mouse	PMID:12052866
Molecular Function	GO:0005515	protein binding	Pik3r2	IPI	PR:Q6SP97	Mouse	PMID:15385169
Molecular Function	GO:0005515	protein binding	Pik3r2	IPI	PR:P34152	Mouse	PMID:25217619
Molecular Function	GO:0046982	protein heterodimerization activity	Pik3r2	IPI	UniProtKB:P26450	Mouse	MGI:MGI:4442277|PMID:20348926
Molecular Function	GO:0019903	protein phosphatase binding	PIK3R2	IPI	UniProtKB:Q12923	Human	PMID:23604317
Molecular Function	GO:0030971	receptor tyrosine kinase binding	PIK3R2	IPI	UniProtKB:Q06418	Human	PMID:10627473
Cellular Component	GO:0005925	focal adhesion	Pik3r2	IDA		Mouse	PMID:25217619
Cellular Component	GO:0005634	nucleus	Pik3r2	IDA		Mouse	MGI:MGI:4442277|PMID:20348926
Cellular Component	GO:0005634	nucleus	Pik3r2	IDA		Mouse	PMID:25217619
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3R2	IPI		Human	PMID:22402981
Biological Process	GO:0032869	cellular response to insulin stimulus	Pik3r2	IDA		Mouse	MGI:MGI:4442277|PMID:20348926
Biological Process	GO:0008286	insulin receptor signaling pathway	Pik3r2	IMP		Mouse	MGI:MGI:4442277|PMID:20348926
Biological Process	GO:0001678	intracellular glucose homeostasis	Pik3r2	IDA		Mouse	MGI:MGI:4442277|PMID:20348926
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	Pik3r2	IMP		Rat	PMID:25652288|RGD:11053232
Biological Process	GO:0043409	negative regulation of MAPK cascade	PIK3R2	IMP		Human	PMID:18694566
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3R2	IDA		Human	PMID:23604317
Biological Process	GO:0045785	positive regulation of cell adhesion	Pik3r2	IDA		Mouse	PMID:25217619
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Pik3r2	IMP		Mouse	MGI:MGI:4442277|PMID:20348926
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pik3r2	IDA		Mouse	MGI:MGI:4442277|PMID:20348926
Biological Process	GO:0030833	regulation of actin filament polymerization	Pik3r2	IMP	MGI:MGI:2159732	Mouse	PMID:25217619
Biological Process	GO:0010506	regulation of autophagy	PIK3R2	IMP		Human	PMID:23604317
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	Pik3r2	IDA		Mouse	PMID:25217619
Biological Process	GO:0051492	regulation of stress fiber assembly	Pik3r2	IMP	MGI:MGI:2159732	Mouse	PMID:25217619
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Pik3r2	IDA		Mouse	MGI:MGI:4442277|PMID:20348926

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern