Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIP5K1A
  • Mouse genes Pip5k1a
  • Rat genes Pip5k1a
  • Zfish genes pip5k1aa,pip5k1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pip5k1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	PIP5K1A	IDA		Human	PMID:15157668
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	PIP5K1A	IDA		Human	PMID:21477596
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	PIP5K1A	IDA		Human	PMID:22942276
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	Pip5k1a	IMP		Mouse	MGI:MGI:6201900|PMID:27739494
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	Pip5k1a	IDA		Mouse	PMID:8798574
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	Pip5k1a	IGI	MGI:MGI:1298224	Mouse	PMID:20622009
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	pip5k1aa	IDA		Zfish	PMID:29959184
Molecular Function	GO:0005524	ATP binding	pip5k1aa	IDA		Zfish	PMID:27439870
Molecular Function	GO:0005524	ATP binding	pip5k1aa	IDA		Zfish	PMID:29959184
Molecular Function	GO:0019900	kinase binding	PIP5K1A	IDA		Human	PMID:15157668
Molecular Function	GO:0001727	lipid kinase activity	pip5k1aa	IDA		Zfish	PMID:26365782
Molecular Function	GO:0052813	phosphatidylinositol bisphosphate kinase activity	pip5k1aa	IDA		Zfish	PMID:27439870
Molecular Function	GO:0005515	protein binding	PIP5K1A	IPI	UniProtKB:Q13574	Human	PMID:15157668
Molecular Function	GO:0005515	protein binding	PIP5K1A	IPI	UniProtKB:Q9H6E5	Human	PMID:18288197
Molecular Function	GO:0005515	protein binding	PIP5K1A	IPI	UniProtKB:P63000	Human	PMID:20660631
Molecular Function	GO:0005515	protein binding	PIP5K1A	IPI	UniProtKB:P01116	Human	PMID:30194290
Molecular Function	GO:0005515	protein binding	PIP5K1A	IPI	UniProtKB:Q8TBX8	Human	PMID:31091439
Molecular Function	GO:0005515	protein binding	Pip5k1a	IPI	PR:Q6U7H8	Mouse	PMID:14701839
Molecular Function	GO:0005515	protein binding	Pip5k1a	IPI	PR:Q91XC0	Mouse	PMID:15870270
Molecular Function	GO:0005515	protein binding	Pip5k1a	IPI	UniProtKB:O08560	Rat	PMID:15157668|RGD:13792527
Cellular Component	GO:0005829	cytosol	PIP5K1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Pip5k1a	IDA		Mouse	PMID:20622009
Cellular Component	GO:0005925	focal adhesion	PIP5K1A	HDA		Human	PMID:21423176
Cellular Component	GO:0030027	lamellipodium	PIP5K1A	IDA		Human	PMID:15157668
Cellular Component	GO:0016607	nuclear speck	PIP5K1A	IDA		Human	PMID:18288197
Cellular Component	GO:0005654	nucleoplasm	PIP5K1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PIP5K1A	IDA		Human	PMID:15157668
Cellular Component	GO:0005634	nucleus	Pip5k1a	IDA		Mouse	PMID:15870270
Cellular Component	GO:0005886	plasma membrane	PIP5K1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PIP5K1A	IDA		Human	PMID:20660631
Cellular Component	GO:0032587	ruffle membrane	PIP5K1A	IDA		Human	PMID:20660631
Cellular Component	GO:0032587	ruffle membrane	Pip5k1a	IDA		Mouse	PMID:15870270
Biological Process	GO:0031532	actin cytoskeleton reorganization	PIP5K1A	IMP		Human	PMID:20660631
Biological Process	GO:0090630	activation of GTPase activity	PIP5K1A	IMP		Human	PMID:20660631
Biological Process	GO:0060326	cell chemotaxis	PIP5K1A	IMP		Human	PMID:20660631
Biological Process	GO:0006897	endocytosis	pip5k1ab	IMP	ZFIN:ZDB-MRPHLNO-150602-1	Zfish	PMID:25838181
Biological Process	GO:0006897	endocytosis	pip5k1ab	IGI	ZFIN:ZDB-GENO-120531-1,ZFIN:ZDB-MRPHLNO-150602-1	Zfish	PMID:25838181
Biological Process	GO:0010761	fibroblast migration	Pip5k1a	IMP		Mouse	PMID:15870270
Biological Process	GO:0048041	focal adhesion assembly	PIP5K1A	IMP		Human	PMID:20660631
Biological Process	GO:0046834	lipid phosphorylation	Pip5k1a	IDA		Mouse	MGI:MGI:83079|PMID:8798574
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process	Pip5k1a	IGI	MGI:MGI:1298224	Mouse	PMID:20622009
Biological Process	GO:0046488	phosphatidylinositol metabolic process	Pip5k1a	IDA		Mouse	PMID:8798574
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	Pip5k1a	IDA		Mouse	MGI:MGI:83079|PMID:8798574
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	pip5k1aa	IDA		Zfish	PMID:29959184|ZFIN:ZDB-PUB-180701-4
Biological Process	GO:0008654	phospholipid biosynthetic process	PIP5K1A	IDA		Human	PMID:15157668
Biological Process	GO:0072659	protein localization to plasma membrane	PIP5K1A	IMP		Human	PMID:20660631
Biological Process	GO:0097178	ruffle assembly	PIP5K1A	IMP		Human	PMID:20660631

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern