Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LILRA1,LILRA2,LILRA3,LILRA4,LILRA6,LILRB3
  • Mouse genes Pira2
  • Rat genes Lilrb2,Lilrb3l,Pirb
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pira2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015026	coreceptor activity	LILRA4	IDA		Human	PMID:16735691
Molecular Function	GO:0001791	IgM binding	LILRA2	IDA		Human	PMID:27572839
Molecular Function	GO:0005515	protein binding	LILRB3	IPI	UniProtKB:P29350	Human	PMID:18802077
Molecular Function	GO:0005515	protein binding	LILRB3	IPI	UniProtKB:P05783	Human	PMID:26769854
Molecular Function	GO:0005515	protein binding	LILRB3	IPI	UniProtKB:P05787	Human	PMID:26769854
Molecular Function	GO:0005515	protein binding	LILRA4	IPI	UniProtKB:Q10589	Human	PMID:19564354
Molecular Function	GO:0005102	signaling receptor binding	LILRA4	IPI	UniProtKB:P30273	Human	PMID:16735691
Cellular Component	GO:0032998	Fc-epsilon receptor I complex	LILRA4	IDA		Human	PMID:16735691
Cellular Component	GO:0005886	plasma membrane	LILRA4	IDA		Human	PMID:16735691
Cellular Component	GO:0005886	plasma membrane	LILRA2	IDA		Human	PMID:22479404
Cellular Component	GO:0005886	plasma membrane	LILRA2	IDA		Human	PMID:27572839
Biological Process	GO:0038095	Fc-epsilon receptor signaling pathway	LILRA4	IMP		Human	PMID:16735691
Biological Process	GO:0002220	innate immune response activating cell surface receptor signaling pathway	LILRA2	IDA		Human	PMID:27572839
Biological Process	GO:0032687	negative regulation of interferon-alpha production	LILRA4	IMP		Human	PMID:16735691
Biological Process	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	LILRA2	IMP		Human	PMID:22479404
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	LILRB3	IDA		Human	PMID:18802077
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	LILRA2	IMP		Human	PMID:22479404
Biological Process	GO:0034156	negative regulation of toll-like receptor 7 signaling pathway	LILRA4	IMP		Human	PMID:16735691
Biological Process	GO:0034164	negative regulation of toll-like receptor 9 signaling pathway	LILRA4	IMP		Human	PMID:16735691
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	LILRA4	IMP		Human	PMID:16735691
Biological Process	GO:0002283	neutrophil activation involved in immune response	LILRA2	IDA		Human	PMID:27572839
Biological Process	GO:0051928	positive regulation of calcium ion transport	LILRA2	IDA		Human	PMID:12393390
Biological Process	GO:0050867	positive regulation of cell activation	LILRA2	IDA		Human	PMID:12393390
Biological Process	GO:0071657	positive regulation of granulocyte colony-stimulating factor production	LILRA2	IMP		Human	PMID:22479404
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	LILRA2	IMP		Human	PMID:22479404
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	LILRA2	IDA		Human	PMID:12393390
Biological Process	GO:0032755	positive regulation of interleukin-6 production	LILRA2	IDA		Human	PMID:12393390
Biological Process	GO:0032755	positive regulation of interleukin-6 production	LILRA2	IMP		Human	PMID:22479404
Biological Process	GO:0032757	positive regulation of interleukin-8 production	LILRA2	IMP		Human	PMID:22479404
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	LILRA2	IDA		Human	PMID:12393390

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern