Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LILRA3,LILRB1,LILRB2,LILRB3,LILRB5
  • Mouse genes Pirb
  • Rat genes Lilrb2,Lilrb3l,Pirb
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pirb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	LILRB2	IMP		Human	PMID:24052308
Molecular Function	GO:0001540	amyloid-beta binding	Pirb	IDA		Mouse	MGI:MGI:5511064|PMID:24052308
Molecular Function	GO:0001540	amyloid-beta binding	Pirb	IMP		Mouse	MGI:MGI:5511064|PMID:24052308
Molecular Function	GO:0050839	cell adhesion molecule binding	LILRB2	IPI	UniProtKB:P15813	Human	PMID:19124746
Molecular Function	GO:0030107	HLA-A specific inhibitory MHC class I receptor activity	LILRB1	IDA		Human	PMID:18684926
Molecular Function	GO:0030109	HLA-B specific inhibitory MHC class I receptor activity	LILRB1	IDA		Human	PMID:11907092
Molecular Function	GO:0032396	inhibitory MHC class I receptor activity	LILRB2	IMP		Human	PMID:14971032
Molecular Function	GO:0032396	inhibitory MHC class I receptor activity	LILRB2	IMP		Human	PMID:20008523
Molecular Function	GO:0032396	inhibitory MHC class I receptor activity	LILRB2	IDA		Human	PMID:20702625
Molecular Function	GO:0042288	MHC class I protein binding	LILRB2	IDA		Human	PMID:14971032
Molecular Function	GO:0042288	MHC class I protein binding	LILRB2	IDA		Human	PMID:18802077
Molecular Function	GO:0042288	MHC class I protein binding	LILRB2	IPI	UniProtKB:P04439	Human	PMID:19124746
Molecular Function	GO:0042288	MHC class I protein binding	LILRB2	IPI	UniProtKB:P17693	Human	PMID:20702625
Molecular Function	GO:0042288	MHC class I protein binding	LILRB2	IPI	UniProtKB:P17693	Human	PMID:22802125
Molecular Function	GO:0042288	MHC class I protein binding	LILRB2	IDA		Human	PMID:9842885
Molecular Function	GO:0042288	MHC class I protein binding	LILRB1	IPI	UniProtKB:P08560	Human	PMID:17869268
Molecular Function	GO:0042288	MHC class I protein binding	LILRB1	IDA		Human	PMID:18094328
Molecular Function	GO:0042288	MHC class I protein binding	LILRB1	IPI	UniProtKB:P08560	Human	PMID:18094328
Molecular Function	GO:0042288	MHC class I protein binding	LILRB1	IMP		Human	PMID:18398485
Molecular Function	GO:0042288	MHC class I protein binding	LILRB1	IDA		Human	PMID:18802077
Molecular Function	GO:0042288	MHC class I protein binding	LILRB1	IPI	UniProtKB:P04439	Human	PMID:19124746
Molecular Function	GO:0042288	MHC class I protein binding	LILRB1	IPI	UniProtKB:P17693	Human	PMID:20702625
Molecular Function	GO:0042288	MHC class I protein binding	LILRB1	IDA		Human	PMID:21213105
Molecular Function	GO:0042288	MHC class I protein binding	LILRB1	IMP		Human	PMID:21233315
Molecular Function	GO:0042288	MHC class I protein binding	LILRB1	IPI	UniProtKB:P08560	Human	PMID:9285411
Molecular Function	GO:0042288	MHC class I protein binding	LILRB1	IDA		Human	PMID:9842885
Molecular Function	GO:0032393	MHC class I receptor activity	LILRB1	IDA		Human	PMID:17869268
Molecular Function	GO:0032393	MHC class I receptor activity	LILRB1	IDA		Human	PMID:18094328
Molecular Function	GO:0032393	MHC class I receptor activity	LILRB1	IDA		Human	PMID:18398485
Molecular Function	GO:0032393	MHC class I receptor activity	LILRB1	IDA		Human	PMID:18802077
Molecular Function	GO:0032393	MHC class I receptor activity	LILRB1	IDA		Human	PMID:21213105
Molecular Function	GO:0032393	MHC class I receptor activity	LILRB1	IDA		Human	PMID:21233315
Molecular Function	GO:0032393	MHC class I receptor activity	LILRB1	IDA		Human	PMID:9285411
Molecular Function	GO:0032393	MHC class I receptor activity	LILRB1	IDA		Human	PMID:9842885
Molecular Function	GO:0023029	MHC class Ib protein binding	LILRB2	IDA		Human	PMID:11169396
Molecular Function	GO:0023029	MHC class Ib protein binding	LILRB2	IPI	UniProtKB:P01889	Human	PMID:20008523
Molecular Function	GO:0023029	MHC class Ib protein binding	LILRB1	IDA		Human	PMID:11169396
Molecular Function	GO:0023025	MHC class Ib protein complex binding	LILRB2	IDA		Human	PMID:17056715
Molecular Function	GO:0023025	MHC class Ib protein complex binding	LILRB1	IDA		Human	PMID:17056715
Molecular Function	GO:0023025	MHC class Ib protein complex binding	LILRB1	IDA		Human	PMID:28636952
Molecular Function	GO:0032394	MHC class Ib receptor activity	LILRB1	IDA		Human	PMID:24453251
Molecular Function	GO:0005515	protein binding	LILRB3	IPI	UniProtKB:P29350	Human	PMID:18802077
Molecular Function	GO:0005515	protein binding	LILRB3	IPI	UniProtKB:P05783	Human	PMID:26769854
Molecular Function	GO:0005515	protein binding	LILRB3	IPI	UniProtKB:P05787	Human	PMID:26769854
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P30511	Human	PMID:11169396
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P17693	Human	PMID:12853576
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P17693	Human	PMID:16455647
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P17693	Human	PMID:17056715
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P29350	Human	PMID:18802077
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:Q86XS5	Human	PMID:22660330
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:Q9UKU9	Human	PMID:22660330
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P17693-2	Human	PMID:22802125
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P17693-5	Human	PMID:22802125
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P17693-6	Human	PMID:22802125
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:24052308
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P17693	Human	PMID:24899623
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:Q86XS5	Human	PMID:24899623
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:Q9UKU9	Human	PMID:24899623
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P46531	Human	PMID:25714926
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P01889	Human	PMID:27649529
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:28219245
Molecular Function	GO:0005515	protein binding	LILRB2	IPI	UniProtKB:P17693-2	Human	PMID:28348268
Molecular Function	GO:0005515	protein binding	LILRB1	IPI	UniProtKB:P30511	Human	PMID:11169396
Molecular Function	GO:0005515	protein binding	LILRB1	IPI	UniProtKB:P17693	Human	PMID:12853576
Molecular Function	GO:0005515	protein binding	LILRB1	IPI	UniProtKB:P17693	Human	PMID:12874224
Molecular Function	GO:0005515	protein binding	LILRB1	IPI	UniProtKB:P17693	Human	PMID:16455647
Molecular Function	GO:0005515	protein binding	LILRB1	IPI	UniProtKB:P29350	Human	PMID:18802077
Molecular Function	GO:0005515	protein binding	LILRB1	IPI	UniProtKB:P17693	Human	PMID:19583775
Molecular Function	GO:0005515	protein binding	LILRB1	IPI	UniProtKB:P30511	Human	PMID:28636952
Molecular Function	GO:0005515	protein binding	Pirb	IPI	UniProtKB:P18760	Mouse	MGI:MGI:5511064|PMID:24052308
Molecular Function	GO:0005515	protein binding	Pirb	IPI	UniProtKB:P35235	Mouse	MGI:MGI:5432830|PMID:22660330
Molecular Function	GO:0005515	protein binding	Pirb	IPI	UniProtKB:P05067:PRO_0000000092|UniProtKB:P35235	Mouse	MGI:MGI:5511064|PMID:24052308
Molecular Function	GO:0042803	protein homodimerization activity	LILRB2	IDA		Human	PMID:24052308
Molecular Function	GO:0042803	protein homodimerization activity	LILRB1	IPI	UniProtKB:Q8NHL6	Human	PMID:21213105
Molecular Function	GO:0042803	protein homodimerization activity	Pirb	IDA		Mouse	MGI:MGI:5511064|PMID:24052308
Molecular Function	GO:0008157	protein phosphatase 1 binding	LILRB2	IPI	UniProtKB:P29350	Human	PMID:9842885
Molecular Function	GO:0008157	protein phosphatase 1 binding	LILRB1	IPI	UniProtKB:P29350	Human	PMID:11907092
Molecular Function	GO:0008157	protein phosphatase 1 binding	LILRB1	IPI	UniProtKB:P29350	Human	PMID:18802077
Molecular Function	GO:0008157	protein phosphatase 1 binding	LILRB1	IPI	UniProtKB:P29350	Human	PMID:9285411
Molecular Function	GO:0008157	protein phosphatase 1 binding	LILRB1	IPI	UniProtKB:P29350	Human	PMID:9842885
Molecular Function	GO:0044877	protein-containing complex binding	LILRB2	IPI	ComplexPortal:CPX-1134	Human	PMID:24052308
Molecular Function	GO:0044877	protein-containing complex binding	Pirb	IPI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5511064|PMID:24052308
Molecular Function	GO:0042169	SH2 domain binding	LILRB1	IDA		Human	PMID:11907092
Cellular Component	GO:0009986	cell surface	LILRB2	IDA		Human	PMID:14971032
Cellular Component	GO:0009986	cell surface	LILRB2	IDA		Human	PMID:22802125
Cellular Component	GO:0005737	cytoplasm	LILRB2	IDA		Human	PMID:19124746
Cellular Component	GO:0005737	cytoplasm	LILRB1	IDA		Human	PMID:15585844
Cellular Component	GO:0009897	external side of plasma membrane	LILRB1	IDA		Human	PMID:15585844
Cellular Component	GO:0009897	external side of plasma membrane	LILRB1	IDA		Human	PMID:17869268
Cellular Component	GO:0009897	external side of plasma membrane	LILRB1	IDA		Human	PMID:18094328
Cellular Component	GO:0009897	external side of plasma membrane	LILRB1	IDA		Human	PMID:18684926
Cellular Component	GO:0009897	external side of plasma membrane	LILRB1	IDA		Human	PMID:21233315
Cellular Component	GO:0009897	external side of plasma membrane	LILRB1	IDA		Human	PMID:21551166
Cellular Component	GO:0009897	external side of plasma membrane	LILRB1	IDA		Human	PMID:9285411
Cellular Component	GO:0005615	extracellular space	LILRB2	IDA		Human	PMID:14971032
Biological Process	GO:0001782	B cell homeostasis	Pirb	IMP	MGI:MGI:2180757	Mouse	PMID:12021780
Biological Process	GO:0019724	B cell mediated immunity	Pirb	IMP	MGI:MGI:2180757	Mouse	PMID:12021780
Biological Process	GO:0071222	cellular response to lipopolysaccharide	LILRB2	IMP		Human	PMID:14971032
Biological Process	GO:0071222	cellular response to lipopolysaccharide	LILRB1	IEP		Human	PMID:18094328
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Pirb	IMP	MGI:MGI:2180757	Mouse	PMID:12021780
Biological Process	GO:0051607	defense response to virus	LILRB1	IDA		Human	PMID:15585844
Biological Process	GO:0097028	dendritic cell differentiation	LILRB1	IEP		Human	PMID:18094328
Biological Process	GO:0002774	Fc receptor mediated inhibitory signaling pathway	LILRB2	IDA		Human	PMID:9842885
Biological Process	GO:0002774	Fc receptor mediated inhibitory signaling pathway	LILRB1	IDA		Human	PMID:9842885
Biological Process	GO:0034113	heterotypic cell-cell adhesion	LILRB2	IDA		Human	PMID:19124746
Biological Process	GO:0002767	immune response-inhibiting cell surface receptor signaling pathway	LILRB2	IMP		Human	PMID:14971032
Biological Process	GO:0002767	immune response-inhibiting cell surface receptor signaling pathway	LILRB2	IDA		Human	PMID:20702625
Biological Process	GO:0140105	interleukin-10-mediated signaling pathway	LILRB2	IEP		Human	PMID:17163451
Biological Process	GO:0007611	learning or memory	Pirb	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:5511064|PMID:24052308
Biological Process	GO:0043011	myeloid dendritic cell differentiation	Pirb	IMP	MGI:MGI:2180757	Mouse	PMID:12021780
Biological Process	GO:0046636	negative regulation of alpha-beta T cell activation	LILRB1	IDA		Human	PMID:21213105
Biological Process	GO:0002578	negative regulation of antigen processing and presentation	LILRB2	IDA		Human	PMID:19124746
Biological Process	GO:0051926	negative regulation of calcium ion transport	LILRB2	IDA		Human	PMID:9842885
Biological Process	GO:0051926	negative regulation of calcium ion transport	LILRB1	IDA		Human	PMID:9842885
Biological Process	GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation	LILRB1	IDA		Human	PMID:21213105
Biological Process	GO:0045786	negative regulation of cell cycle	LILRB1	IDA		Human	PMID:21551166
Biological Process	GO:0002719	negative regulation of cytokine production involved in immune response	LILRB1	IDA		Human	PMID:18094328
Biological Process	GO:2000669	negative regulation of dendritic cell apoptotic process	LILRB1	IDA		Human	PMID:18094328
Biological Process	GO:2001199	negative regulation of dendritic cell differentiation	LILRB1	IMP		Human	PMID:18684926
Biological Process	GO:0045806	negative regulation of endocytosis	LILRB1	IDA		Human	PMID:18094328
Biological Process	GO:0032688	negative regulation of interferon-beta production	LILRB1	IDA		Human	PMID:21213105
Biological Process	GO:0032693	negative regulation of interleukin-10 production	LILRB1	IDA		Human	PMID:18094328
Biological Process	GO:0032695	negative regulation of interleukin-12 production	LILRB1	IDA		Human	PMID:18094328
Biological Process	GO:0032945	negative regulation of mononuclear cell proliferation	LILRB1	IDA		Human	PMID:21551166
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	LILRB1	IDA		Human	PMID:12874224
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	LILRB1	IDA		Human	PMID:18398485
Biological Process	GO:2001205	negative regulation of osteoclast development	LILRB1	IDA		Human	PMID:18802077
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	LILRB3	IDA		Human	PMID:18802077
Biological Process	GO:0051248	negative regulation of protein metabolic process	Pirb	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5511064|PMID:24052308
Biological Process	GO:0014063	negative regulation of serotonin secretion	LILRB1	IDA		Human	PMID:11907092
Biological Process	GO:2001189	negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	LILRB1	IDA		Human	PMID:18094328
Biological Process	GO:2000524	negative regulation of T cell costimulation	LILRB2	IMP		Human	PMID:17163451
Biological Process	GO:0001915	negative regulation of T cell mediated cytotoxicity	LILRB1	IDA		Human	PMID:21213105
Biological Process	GO:0042130	negative regulation of T cell proliferation	LILRB2	IMP		Human	PMID:14971032
Biological Process	GO:0042130	negative regulation of T cell proliferation	LILRB2	IMP		Human	PMID:17163451
Biological Process	GO:0042130	negative regulation of T cell proliferation	LILRB2	IDA		Human	PMID:19124746
Biological Process	GO:0042130	negative regulation of T cell proliferation	LILRB2	IDA		Human	PMID:20702625
Biological Process	GO:0042130	negative regulation of T cell proliferation	LILRB1	IDA		Human	PMID:15585844
Biological Process	GO:0071635	negative regulation of transforming growth factor beta production	LILRB1	IDA		Human	PMID:18094328
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	LILRB1	IDA		Human	PMID:18684926
Biological Process	GO:0032689	negative regulation of type II interferon production	LILRB1	IDA		Human	PMID:17869268
Biological Process	GO:0032689	negative regulation of type II interferon production	LILRB1	IDA		Human	PMID:18684926
Biological Process	GO:0043065	positive regulation of apoptotic process	LILRB1	IDA		Human	PMID:21551166
Biological Process	GO:0002230	positive regulation of defense response to virus by host	LILRB1	IDA		Human	PMID:18398485
Biological Process	GO:2001193	positive regulation of gamma-delta T cell activation involved in immune response	LILRB1	IDA		Human	PMID:21233315
Biological Process	GO:0010628	positive regulation of gene expression	LILRB1	IDA		Human	PMID:18094328
Biological Process	GO:1900454	positive regulation of long-term synaptic depression	Pirb	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:5511064|PMID:24052308
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	LILRB1	IDA		Human	PMID:19304799
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	Pirb	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5511064|PMID:24052308
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	LILRB2	IMP		Human	PMID:20448110
Biological Process	GO:0042102	positive regulation of T cell proliferation	LILRB2	IDA		Human	PMID:14971032
Biological Process	GO:0002666	positive regulation of T cell tolerance induction	LILRB2	IMP		Human	PMID:20008523
Biological Process	GO:0002666	positive regulation of T cell tolerance induction	LILRB2	IMP		Human	PMID:20448110
Biological Process	GO:0002645	positive regulation of tolerance induction	LILRB2	IMP		Human	PMID:22802125
Biological Process	GO:0032729	positive regulation of type II interferon production	LILRB1	IDA		Human	PMID:11907092
Biological Process	GO:0032729	positive regulation of type II interferon production	LILRB1	IDA		Human	PMID:15585844
Biological Process	GO:1900271	regulation of long-term synaptic potentiation	Pirb	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5511064|PMID:24052308
Biological Process	GO:0009615	response to virus	LILRB1	IDA		Human	PMID:17869268
Biological Process	GO:0009615	response to virus	LILRB1	IDA		Human	PMID:18094328
Biological Process	GO:0009615	response to virus	LILRB1	IDA		Human	PMID:9285411
Biological Process	GO:0007165	signal transduction	LILRB2	IMP		Human	PMID:20008523
Biological Process	GO:0007165	signal transduction	LILRB2	IDA		Human	PMID:20702625
Biological Process	GO:0007165	signal transduction	LILRB1	IDA		Human	PMID:18802077
Biological Process	GO:0002309	T cell proliferation involved in immune response	LILRB1	IDA		Human	PMID:18094328

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern