Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PITX1
  • Mouse genes Pitx1
  • Rat genes Pitx1
  • Zfish genes pitx1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pitx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Pitx1	IDA		Mouse	MGI:MGI:80738|PMID:8675014
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Pitx1	IMP		Rat	PMID:12223489|RGD:633538
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q92997	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q93062	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:A0A0C4DGF1	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:O94829	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:P36406	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q93062-3	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q99932-2	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q9Y5V3	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q08379	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q93062-3	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q99750	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q93062	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q93062	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:A0A0B4J2F2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:A0A0C4DGF1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:A1KXE4-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:A5LHX3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:A7E2Y1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:A8MV65-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:G4XUV3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:O15496	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:O60806	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:O75935-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:O94829	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:O95967	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:P05121	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:P0CG21	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:P15976-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:P35548	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:P36406	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:P40199	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:P78385	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:P86480	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q01974	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q03989	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q12888	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q13077	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q13882	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q14847-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q16348	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q3LI64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q3LI72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q3SYF9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q52LG2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q53HC5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q5BKX5-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q5SWW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q5W0N0-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q6NVU6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q6PEX3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q6UWQ7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q7Z6R9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q86V38	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q86WV8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q86Y13	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q8IUC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q8IUC3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q8IV28	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q8IWL8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q8N6F8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q8NFV4-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q8TDC0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q92567-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q92997	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q96CS7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q96M29	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q99471	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q99932-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q9BYR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q9H5F2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q9NP55	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q9NRY6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q9NXR5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q9UGK8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q9ULV5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q9ULX6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q9Y458	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q9Y5V3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PITX1	IPI	UniProtKB:Q92870-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Pitx1	IPI	PR:P50481	Mouse	PMID:9192866
Molecular Function	GO:0005515	protein binding	Pitx1	IPI	PR:O55203-2	Mouse	PMID:9192866
Molecular Function	GO:0005515	protein binding	Pitx1	IPI	PR:O55203-1	Mouse	PMID:9192866
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pitx1	IDA		Mouse	MGI:MGI:80738|PMID:8675014
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	PITX1	IPI	UniProtKB:P28069	Human	PMID:26612202
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PITX1	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Pitx1	IDA		Mouse	PMID:19531352
Cellular Component	GO:0005634	nucleus	PITX1	IDA		Human	PMID:17984056
Cellular Component	GO:0005634	nucleus	Pitx1	IDA		Mouse	PMID:19531352
Cellular Component	GO:0005667	transcription regulator complex	Pitx1	IDA		Mouse	PMID:9192866
Biological Process	GO:0014707	branchiomeric skeletal muscle development	Pitx1	IMP	MGI:MGI:2384494	Mouse	PMID:17384148
Biological Process	GO:0051216	cartilage development	Pitx1	IMP	MGI:MGI:1857659	Mouse	PMID:10101115
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Pitx1	IMP		Mouse	MGI:MGI:5299938|PMID:22071103
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Pitx1	IGI	MGI:MGI:109340	Mouse	PMID:18231602
Biological Process	GO:0035137	hindlimb morphogenesis	Pitx1	IMP	MGI:MGI:1934200	Mouse	PMID:10049363
Biological Process	GO:0035137	hindlimb morphogenesis	Pitx1	IMP	MGI:MGI:1857659	Mouse	PMID:10101115
Biological Process	GO:0035137	hindlimb morphogenesis	Pitx1	IDA		Mouse	PMID:16989801
Biological Process	GO:0035137	hindlimb morphogenesis	Pitx1	IDA		Mouse	PMID:15621531
Biological Process	GO:0048625	myoblast fate commitment	Pitx1	IMP	MGI:MGI:2384494	Mouse	PMID:17384148
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Pitx1	IMP		Mouse	MGI:MGI:5619463|PMID:21300782
Biological Process	GO:0021983	pituitary gland development	Pitx1	IMP	MGI:MGI:1934200	Mouse	PMID:10049363
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx1	IDA		Mouse	MGI:MGI:80738|PMID:8675014
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx1	IDA	MGI:MGI:102673,PR:O55203-2	Mouse	PMID:9192866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx1	IDA	PR:O55203-2	Mouse	PMID:9192866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx1	IDA	MGI:MGI:102673,MGI:MGI:894762	Mouse	PMID:9192866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx1	IGI	MGI:MGI:894670	Mouse	PMID:10431247
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx1	IDA	MGI:MGI:894762	Mouse	PMID:9192866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx1	IDA	PR:O55203-1	Mouse	PMID:9192866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx1	IDA		Mouse	PMID:9192866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx1	IDA	MGI:MGI:102673,PR:O55203-1	Mouse	PMID:9192866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx1	IGI	MGI:MGI:102673	Mouse	PMID:10431247
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx1	IGI	MGI:MGI:1342291	Mouse	PMID:10431247
Biological Process	GO:0006355	regulation of DNA-templated transcription	Pitx1	IMP		Rat	PMID:12223489|RGD:633538
Biological Process	GO:0001501	skeletal system development	Pitx1	IMP	MGI:MGI:1857659	Mouse	PMID:10101115

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern