Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PITX2
  • Mouse genes Pitx2
  • Rat genes Pitx2
  • Zfish genes pitx2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pitx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Pitx2	IDA		Mouse	PMID:17767158
Molecular Function	GO:0003682	chromatin binding	Pitx2	IDA		Mouse	PMID:11157981
Molecular Function	GO:0031490	chromatin DNA binding	Pitx2	IDA		Mouse	PMID:21035439
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Pitx2	IDA		Rat	PMID:11032870|RGD:5132604
Molecular Function	GO:0003700	DNA-binding transcription factor activity	PITX2	IDA		Human	PMID:15385555
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Pitx2	IDA		Mouse	PMID:12464179
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Pitx2	IDA		Mouse	PMID:11157981
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PITX2	IDA		Human	PMID:9685346
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Pitx2	IDA		Mouse	PMID:21035439
Molecular Function	GO:0005515	protein binding	PITX2	IPI	UniProtKB:P67809	Human	PMID:19174163
Molecular Function	GO:0005515	protein binding	PITX2	IPI	UniProtKB:P09022	Human	PMID:23088713
Molecular Function	GO:0005515	protein binding	Pitx2	IPI	UniProtKB:P46938|UniProtKB:Q60795	Mouse	MGI:MGI:5800620|PMID:27251288
Molecular Function	GO:0005515	protein binding	Pitx2	IPI	PR:P70323	Mouse	PMID:20816801
Molecular Function	GO:0005515	protein binding	Pitx2	IPI	MGI:MGI:1932051	Mouse	PMID:12464179
Molecular Function	GO:0005515	protein binding	Pitx2	IPI	PR:O70400	Mouse	PMID:12464179
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pitx2	IDA		Rat	PMID:11032870|RGD:5132604
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	PITX2	IPI	UniProtKB:P28069	Human	PMID:9685346
Molecular Function	GO:0043565	sequence-specific DNA binding	Pitx2	IDA		Mouse	PMID:20816801
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PITX2	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	PITX2	IDA		Human	PMID:9685346
Cellular Component	GO:0005737	cytoplasm	Pitx2	IDA		Mouse	PMID:19531352
Cellular Component	GO:0005654	nucleoplasm	PITX2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PITX2	IDA		Human	PMID:19251162
Cellular Component	GO:0005634	nucleus	Pitx2	IDA		Mouse	PMID:10822271
Cellular Component	GO:0005634	nucleus	Pitx2	IDA		Mouse	PMID:19531352
Cellular Component	GO:0005634	nucleus	Pitx2	IDA		Rat	PMID:17982271|RGD:5131997
Cellular Component	GO:0005667	transcription regulator complex	PITX2	IDA		Human	PMID:15385555
Cellular Component	GO:0005667	transcription regulator complex	Pitx2	IDA		Mouse	PMID:12464179
Biological Process	GO:0009653	anatomical structure morphogenesis	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:10499585
Biological Process	GO:0009887	animal organ morphogenesis	Pitx2	IMP	MGI:MGI:1857880	Mouse	PMID:10572050
Biological Process	GO:0055009	atrial cardiac muscle tissue morphogenesis	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:11493526
Biological Process	GO:0003171	atrioventricular valve development	Pitx2	IMP	MGI:MGI:1857844,MGI:MGI:2386742	Mouse	PMID:18292603
Biological Process	GO:0007420	brain development	Pitx2	IEP		Rat	PMID:9748586|RGD:69931
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Pitx2	IMP	MGI:MGI:2445428	Mouse	PMID:12397115
Biological Process	GO:0043010	camera-type eye development	PITX2	IMP		Human	PMID:9618168
Biological Process	GO:0043010	camera-type eye development	pitx2	IMP	ZFIN:ZDB-GENO-161010-8	Zfish	PMID:27297886
Biological Process	GO:0043010	camera-type eye development	pitx2	IMP	ZFIN:ZDB-GENO-161010-5	Zfish	PMID:27297886
Biological Process	GO:0043010	camera-type eye development	pitx2	IMP	ZFIN:ZDB-GENO-180928-1	Zfish	PMID:29506241
Biological Process	GO:0048593	camera-type eye morphogenesis	pitx2	IMP	ZFIN:ZDB-MRPHLNO-120911-5	Zfish	PMID:22125274
Biological Process	GO:0055007	cardiac muscle cell differentiation	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:17234970
Biological Process	GO:0055007	cardiac muscle cell differentiation	Pitx2	IMP	MGI:MGI:2445428	Mouse	PMID:12397115
Biological Process	GO:0048738	cardiac muscle tissue development	Pitx2	IMP	MGI:MGI:1857844,MGI:MGI:2445429	Mouse	PMID:16836994
Biological Process	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	Pitx2	IMP		Mouse	MGI:MGI:2446944|PMID:12464179
Biological Process	GO:0061325	cell proliferation involved in outflow tract morphogenesis	Pitx2	IMP		Mouse	MGI:MGI:2446944|PMID:12464179
Biological Process	GO:0061325	cell proliferation involved in outflow tract morphogenesis	Pitx2	IMP	MGI:MGI:1857844,MGI:MGI:2445429	Mouse	PMID:16836994
Biological Process	GO:0061386	closure of optic fissure	pitx2	IMP	ZFIN:ZDB-MRPHLNO-110714-1	Zfish	PMID:21555593
Biological Process	GO:0061303	cornea development in camera-type eye	pitx2	IMP	ZFIN:ZDB-GENO-161010-8	Zfish	PMID:27297886
Biological Process	GO:0061303	cornea development in camera-type eye	pitx2	IMP	ZFIN:ZDB-GENO-180928-1	Zfish	PMID:29506241
Biological Process	GO:0061303	cornea development in camera-type eye	pitx2	IMP	ZFIN:ZDB-GENO-161010-5	Zfish	PMID:27297886
Biological Process	GO:0035993	deltoid tuberosity development	PITX2	IMP		Human	PMID:18312615
Biological Process	GO:0035993	deltoid tuberosity development	Pitx2	IMP		Mouse	MGI:MGI:3794216|PMID:18312615
Biological Process	GO:0071907	determination of digestive tract left/right asymmetry	pitx2	IDA		Zfish	PMID:10662647
Biological Process	GO:0035462	determination of left/right asymmetry in diencephalon	pitx2	IMP	ZFIN:ZDB-MRPHLNO-120911-4	Zfish	PMID:24598158
Biological Process	GO:0035462	determination of left/right asymmetry in diencephalon	pitx2	IMP	ZFIN:ZDB-MRPHLNO-140731-1	Zfish	PMID:24598158
Biological Process	GO:0007368	determination of left/right symmetry	Pitx2	IMP		Mouse	MGI:MGI:1277589|PMID:9708732
Biological Process	GO:0007368	determination of left/right symmetry	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:24091014
Biological Process	GO:0007368	determination of left/right symmetry	Pitx2	IMP	MGI:MGI:1857844	Mouse	PMID:10498698
Biological Process	GO:0007368	determination of left/right symmetry	Pitx2	IMP	MGI:MGI:2445428	Mouse	PMID:12397115
Biological Process	GO:0007368	determination of left/right symmetry	Pitx2	IMP	MGI:MGI:1857846	Mouse	PMID:10498698
Biological Process	GO:0007368	determination of left/right symmetry	Pitx2	IMP	MGI:MGI:1857880	Mouse	PMID:10572050
Biological Process	GO:0007368	determination of left/right symmetry	Pitx2	IMP	MGI:MGI:2384494	Mouse	PMID:10499586
Biological Process	GO:0007368	determination of left/right symmetry	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:11493526
Biological Process	GO:0055123	digestive system development	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:11493526
Biological Process	GO:0031076	embryonic camera-type eye development	Pitx2	IMP	MGI:MGI:1857846	Mouse	PMID:10498698
Biological Process	GO:0031076	embryonic camera-type eye development	Pitx2	IMP	MGI:MGI:1857880	Mouse	PMID:10572050
Biological Process	GO:0031076	embryonic camera-type eye development	Pitx2	IMP	MGI:MGI:1857844	Mouse	PMID:10498698
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	pitx2	IMP	ZFIN:ZDB-MRPHLNO-120210-3	Zfish	PMID:22303467
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	pitx2	IMP	ZFIN:ZDB-MRPHLNO-120210-3	Zfish	PMID:22303467
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	Pitx2	IMP	MGI:MGI:3767234	Mouse	PMID:21550054
Biological Process	GO:0060971	embryonic heart tube left/right pattern formation	Pitx2	IMP		Mouse	MGI:MGI:3783941|PMID:17234970
Biological Process	GO:0060971	embryonic heart tube left/right pattern formation	pitx2	IDA		Zfish	PMID:10662647
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Pitx2	IGI	MGI:MGI:107374	Mouse	PMID:18231602
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	pitx2	IMP	ZFIN:ZDB-MRPHLNO-120911-5	Zfish	PMID:22125274
Biological Process	GO:0061031	endodermal digestive tract morphogenesis	Pitx2	IMP	MGI:MGI:3767234	Mouse	PMID:21550054
Biological Process	GO:0021538	epithalamus development	pitx2	IMP	ZFIN:ZDB-MRPHLNO-120911-4	Zfish	PMID:24598158
Biological Process	GO:0021538	epithalamus development	pitx2	IMP	ZFIN:ZDB-MRPHLNO-140731-1	Zfish	PMID:24598158
Biological Process	GO:0002074	extraocular skeletal muscle development	Pitx2	IMP	MGI:MGI:1857846	Mouse	PMID:21035439
Biological Process	GO:0002074	extraocular skeletal muscle development	Pitx2	IMP	MGI:MGI:1857844	Mouse	PMID:16638982
Biological Process	GO:0002074	extraocular skeletal muscle development	Pitx2	IMP	MGI:MGI:1857844	Mouse	PMID:21035439
Biological Process	GO:0060325	face morphogenesis	pitx2	IMP	ZFIN:ZDB-MRPHLNO-120911-5	Zfish	PMID:22125274
Biological Process	GO:0008585	female gonad development	Pitx2	IEP		Rat	PMID:21325833|RGD:5131994
Biological Process	GO:0021986	habenula development	pitx2	IMP	ZFIN:ZDB-MRPHLNO-140731-1	Zfish	PMID:24598158
Biological Process	GO:0021986	habenula development	pitx2	IMP	ZFIN:ZDB-MRPHLNO-120911-4	Zfish	PMID:24598158
Biological Process	GO:0007507	heart development	Pitx2	IMP	MGI:MGI:2384494	Mouse	PMID:12464179
Biological Process	GO:0007507	heart development	Pitx2	IMP	MGI:MGI:1857880	Mouse	PMID:10572050
Biological Process	GO:0007507	heart development	Pitx2	IGI	MGI:MGI:98493	Mouse	PMID:16556915
Biological Process	GO:0007507	heart development	Pitx2	IMP	MGI:MGI:1857846	Mouse	PMID:10498698
Biological Process	GO:0007507	heart development	Pitx2	IMP	MGI:MGI:1857844	Mouse	PMID:10498698
Biological Process	GO:0007507	heart development	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:10499585
Biological Process	GO:0007507	heart development	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:11493526
Biological Process	GO:0007507	heart development	Pitx2	IMP	MGI:MGI:2445428	Mouse	PMID:12397115
Biological Process	GO:0021855	hypothalamus cell migration	Pitx2	IMP	MGI:MGI:1857846	Mouse	PMID:18206388
Biological Process	GO:0001701	in utero embryonic development	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:11493526
Biological Process	GO:0061072	iris morphogenesis	PITX2	IMP		Human	PMID:9437321
Biological Process	GO:0061072	iris morphogenesis	pitx2	IMP	ZFIN:ZDB-GENO-161010-8	Zfish	PMID:27297886
Biological Process	GO:0061072	iris morphogenesis	pitx2	IMP	ZFIN:ZDB-GENO-161010-5	Zfish	PMID:27297886
Biological Process	GO:0060460	left lung morphogenesis	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:11493526
Biological Process	GO:0070986	left/right axis specification	Pitx2	IMP		Mouse	MGI:MGI:3054669|PMID:15475956
Biological Process	GO:0030324	lung development	Pitx2	IMP	MGI:MGI:1857844	Mouse	PMID:10498698
Biological Process	GO:0030324	lung development	Pitx2	IMP	MGI:MGI:1857880	Mouse	PMID:10572050
Biological Process	GO:0030324	lung development	Pitx2	IMP	MGI:MGI:2384494	Mouse	PMID:10499586
Biological Process	GO:0030324	lung development	Pitx2	IMP	MGI:MGI:1857846	Mouse	PMID:10498698
Biological Process	GO:0030324	lung development	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:18231602
Biological Process	GO:0008584	male gonad development	Pitx2	IEP		Rat	PMID:21325833|RGD:5131994
Biological Process	GO:0048382	mesendoderm development	pitx2	IDA		Zfish	PMID:10662647
Biological Process	GO:0030182	neuron differentiation	Pitx2	IEP		Rat	PMID:16408195|RGD:5131998
Biological Process	GO:0001764	neuron migration	Pitx2	IMP	MGI:MGI:1857846	Mouse	PMID:18206388
Biological Process	GO:0042476	odontogenesis	PITX2	IMP		Human	PMID:14630904
Biological Process	GO:0042476	odontogenesis	Pitx2	IMP	MGI:MGI:1857846	Mouse	PMID:10498698
Biological Process	GO:0042476	odontogenesis	Pitx2	IMP	MGI:MGI:2384494	Mouse	PMID:10499586
Biological Process	GO:0042476	odontogenesis	Pitx2	IMP	MGI:MGI:1857844	Mouse	PMID:10498698
Biological Process	GO:0042476	odontogenesis	pitx2	IMP	ZFIN:ZDB-GENO-161010-9	Zfish	PMID:27297886
Biological Process	GO:0042476	odontogenesis	pitx2	IMP	ZFIN:ZDB-GENO-161010-8	Zfish	PMID:27297886
Biological Process	GO:0042476	odontogenesis	pitx2	IMP	ZFIN:ZDB-GENO-161010-5	Zfish	PMID:27297886
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Pitx2	IEP		Rat	PMID:16416307|RGD:2289007
Biological Process	GO:0021983	pituitary gland development	Pitx2	IMP	MGI:MGI:2384494	Mouse	PMID:10499586
Biological Process	GO:0021983	pituitary gland development	Pitx2	IMP	MGI:MGI:1857844	Mouse	PMID:10498698
Biological Process	GO:0021983	pituitary gland development	Pitx2	IMP	MGI:MGI:1857846	Mouse	PMID:10498698
Biological Process	GO:0043388	positive regulation of DNA binding	Pitx2	IDA		Mouse	PMID:21035439
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pitx2	IMP		Mouse	PMID:17767158
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PITX2	IDA		Human	PMID:19251162
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PITX2	IDA		Human	PMID:9685346
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx2	IDA		Mouse	PMID:11157981
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx2	IDA		Mouse	PMID:18458156
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx2	IDA		Rat	PMID:11032870|RGD:5132604
Biological Process	GO:0021501	prechordal plate formation	pitx2	IGI	ZFIN:ZDB-GENO-070530-2	Zfish	PMID:10662647
Biological Process	GO:0021501	prechordal plate formation	pitx2	IGI	ZFIN:ZDB-GENO-080110-7	Zfish	PMID:10662647
Biological Process	GO:0021501	prechordal plate formation	pitx2	IGI	ZFIN:ZDB-GENO-980202-1194	Zfish	PMID:10662647
Biological Process	GO:0021501	prechordal plate formation	pitx2	IGI	ZFIN:ZDB-GENO-980202-1029	Zfish	PMID:10662647
Biological Process	GO:0021501	prechordal plate formation	pitx2	IGI	ZFIN:ZDB-GENO-100714-1	Zfish	PMID:10662647
Biological Process	GO:0021501	prechordal plate formation	pitx2	IGI	ZFIN:ZDB-GENO-980202-1289	Zfish	PMID:10662647
Biological Process	GO:0003350	pulmonary myocardium development	Pitx2	IMP	MGI:MGI:2445428	Mouse	PMID:17823370
Biological Process	GO:0060577	pulmonary vein morphogenesis	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:11493526
Biological Process	GO:0030334	regulation of cell migration	Pitx2	IMP	MGI:MGI:2445428	Mouse	PMID:12397115
Biological Process	GO:0042127	regulation of cell population proliferation	Pitx2	IMP	MGI:MGI:2384494	Mouse	PMID:12464179
Biological Process	GO:1904103	regulation of convergent extension involved in gastrulation	pitx2	IMP	ZFIN:ZDB-GENO-181109-2	Zfish	PMID:29952749
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	PITX2	IDA		Human	PMID:15385555
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	PITX2	IDA		Human	PMID:23975681
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Pitx2	IDA		Mouse	PMID:12464179
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Pitx2	IGI	MGI:MGI:98493	Mouse	PMID:20816801
Biological Process	GO:0043114	regulation of vascular permeability	pitx2	IGI	ZFIN:ZDB-MRPHLNO-061111-2,ZFIN:ZDB-MRPHLNO-061111-3,ZFIN:ZDB-MRPHLNO-130110-5	Zfish	PMID:21282189
Biological Process	GO:0043114	regulation of vascular permeability	pitx2	IGI	ZFIN:ZDB-MRPHLNO-130110-5,ZFIN:ZDB-MRPHLNO-130110-6	Zfish	PMID:21282189
Biological Process	GO:0009725	response to hormone	Pitx2	IEP		Rat	PMID:17982271|RGD:5131997
Biological Process	GO:0033189	response to vitamin A	Pitx2	IEP		Rat	PMID:18955041|RGD:5131996
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	pitx2	IMP	ZFIN:ZDB-MRPHLNO-120911-5	Zfish	PMID:22125274
Biological Process	GO:0007519	skeletal muscle tissue development	Pitx2	IMP	MGI:MGI:1857880	Mouse	PMID:10572050
Biological Process	GO:0048536	spleen development	Pitx2	IMP		Mouse	MGI:MGI:3054669|PMID:15475956
Biological Process	GO:0021763	subthalamic nucleus development	Pitx2	IMP	MGI:MGI:1857846	Mouse	PMID:18206388
Biological Process	GO:0060578	superior vena cava morphogenesis	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:11493526
Biological Process	GO:0035886	vascular associated smooth muscle cell differentiation	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:18458156
Biological Process	GO:0001570	vasculogenesis	Pitx2	IMP	MGI:MGI:2136268	Mouse	PMID:18231602
Biological Process	GO:0055015	ventricular cardiac muscle cell development	Pitx2	IMP	MGI:MGI:1857844,MGI:MGI:2386742	Mouse	PMID:18292603
Biological Process	GO:0060412	ventricular septum morphogenesis	Pitx2	IMP	MGI:MGI:1857844,MGI:MGI:2386742	Mouse	PMID:18292603
Biological Process	GO:0016055	Wnt signaling pathway	Pitx2	IDA		Mouse	PMID:12464179

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern