Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pitx3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PITX3
- Mouse genes Pitx3
- Rat genes Pitx3
- Zfish genes pitx3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pitx3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Pitx3	IDA		Mouse	MGI:MGI:5572899\|PMID:11299318
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Pitx3	IMP		Mouse	MGI:MGI:5572899\|PMID:11299318
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Pitx3	IDA		Rat	PMID:10800925\|RGD:11535131
Molecular Function	GO:0005515	protein binding	Pitx3	IPI	UniProtKB:Q8VIJ6	Mouse	MGI:MGI:3830409\|PMID:19144721
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pitx3	IDA		Mouse	MGI:MGI:5572899\|PMID:11299318
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PITX3	IDA		Human	PMID:28473536
Cellular Component	GO:0000785	chromatin	Pitx3	IDA		Rat	PMID:28743636\|RGD:126775142
Cellular Component	GO:0005737	cytoplasm	Pitx3	IDA		Rat	PMID:18951485\|RGD:11535123
Cellular Component	GO:0005634	nucleus	Pitx3	IDA		Mouse	MGI:MGI:4887332\|PMID:17184956
Cellular Component	GO:0005634	nucleus	Pitx3	IDA		Rat	PMID:18951485\|RGD:11535123
Biological Process	GO:0021984	adenohypophysis development	pitx3	IMP	ZFIN:ZDB-MRPHLNO-050508-3	Zfish	PMID:15728669
Biological Process	GO:0007568	aging	Pitx3	IEP		Rat	PMID:19936865\|RGD:11535129
Biological Process	GO:0043010	camera-type eye development	pitx3	IMP	ZFIN:ZDB-MRPHLNO-050508-3	Zfish	PMID:15728669
Biological Process	GO:1990792	cellular response to glial cell derived neurotrophic factor	Pitx3	IEP		Rat	PMID:21865882\|RGD:6218962
Biological Process	GO:0071542	dopaminergic neuron differentiation	Pitx3	IDA		Mouse	MGI:MGI:3830409\|PMID:19144721
Biological Process	GO:0071542	dopaminergic neuron differentiation	Pitx3	IMP		Mouse	MGI:MGI:3582099\|PMID:15950611
Biological Process	GO:0035270	endocrine system development	pitx3	IMP	ZFIN:ZDB-MRPHLNO-050508-3	Zfish	PMID:15728669
Biological Process	GO:0002088	lens development in camera-type eye	Pitx3	IMP		Mouse	MGI:MGI:3831639\|PMID:19007884
Biological Process	GO:0002088	lens development in camera-type eye	Pitx3	IMP		Mouse	MGI:MGI:4353482\|PMID:19334279
Biological Process	GO:0002088	lens development in camera-type eye	pitx3	IMP	ZFIN:ZDB-MRPHLNO-050508-3	Zfish	PMID:21698120
Biological Process	GO:0070306	lens fiber cell differentiation	Pitx3	IMP		Mouse	MGI:MGI:3831639\|PMID:19007884
Biological Process	GO:0070306	lens fiber cell differentiation	pitx3	IMP	ZFIN:ZDB-MRPHLNO-050508-3	Zfish	PMID:15728669
Biological Process	GO:0002089	lens morphogenesis in camera-type eye	Pitx3	IMP		Mouse	MGI:MGI:4353482\|PMID:19334279
Biological Process	GO:0007626	locomotory behavior	Pitx3	IMP	MGI:MGI:1856667	Mouse	PMID:17919745
Biological Process	GO:0030901	midbrain development	Pitx3	IMP		Mouse	MGI:MGI:3582099\|PMID:15950611
Biological Process	GO:0030901	midbrain development	Pitx3	IMP	MGI:MGI:1856667	Mouse	PMID:14973278
Biological Process	GO:0030901	midbrain development	Pitx3	IMP	MGI:MGI:1856667	Mouse	PMID:17919745
Biological Process	GO:0014014	negative regulation of gliogenesis	Pitx3	IDA		Rat	PMID:18385323\|RGD:11535083
Biological Process	GO:0050768	negative regulation of neurogenesis	Pitx3	IDA		Rat	PMID:18385323\|RGD:11535083
Biological Process	GO:0048666	neuron development	Pitx3	IMP	MGI:MGI:1856667	Mouse	PMID:14973278
Biological Process	GO:1904935	positive regulation of cell proliferation in midbrain	Pitx3	IDA		Rat	PMID:18385323\|RGD:11535083
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pitx3	IDA		Mouse	MGI:MGI:3830409\|PMID:19144721
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	pitx3	IMP	ZFIN:ZDB-MRPHLNO-050508-1	Zfish	PMID:16963235
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Pitx3	IDA		Rat	PMID:18385323\|RGD:11535083
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx3	IDA		Mouse	MGI:MGI:5572899\|PMID:11299318
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pitx3	IMP		Mouse	MGI:MGI:5572899\|PMID:11299318
Biological Process	GO:0006355	regulation of DNA-templated transcription	Pitx3	IDA		Mouse	MGI:MGI:4887332\|PMID:17184956
Biological Process	GO:0010468	regulation of gene expression	Pitx3	IGI	MGI:MGI:95389	Mouse	PMID:23863478
Biological Process	GO:0010468	regulation of gene expression	Pitx3	IMP		Mouse	PMID:19515692
Biological Process	GO:0010468	regulation of gene expression	Pitx3	IDA		Mouse	PMID:17761882
Biological Process	GO:0042220	response to cocaine	Pitx3	IEP		Rat	PMID:17070804\|RGD:5687200
Biological Process	GO:0035902	response to immobilization stress	Pitx3	IEP		Rat	PMID:18951485\|RGD:11535123
Biological Process	GO:1904313	response to methamphetamine hydrochloride	Pitx3	IEP		Rat	PMID:21547080\|RGD:11535124
Biological Process	GO:0043278	response to morphine	Pitx3	IEP		Rat	PMID:23215787\|RGD:11535121

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/15/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.