Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIWIL2
  • Mouse genes Piwil2
  • Rat genes Piwil2
  • Zfish genes piwil2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Piwil2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003729	mRNA binding	Piwil2	IDA		Mouse	MGI:MGI:3842880|PMID:19114715
Molecular Function	GO:0034584	piRNA binding	PIWIL2	IDA		Human	PMID:21193640
Molecular Function	GO:0034584	piRNA binding	Piwil2	IDA		Mouse	MGI:MGI:3815367|PMID:18922463
Molecular Function	GO:0034584	piRNA binding	Piwil2	IDA		Mouse	MGI:MGI:3778312|PMID:18381894
Molecular Function	GO:0034584	piRNA binding	Piwil2	IDA		Mouse	MGI:MGI:3790546|PMID:18404146
Molecular Function	GO:0034584	piRNA binding	Piwil2	IDA		Mouse	MGI:MGI:3843431|PMID:16751777
Molecular Function	GO:0034584	piRNA binding	Piwil2	IDA		Mouse	MGI:MGI:3709799|PMID:17446352
Molecular Function	GO:0034584	piRNA binding	piwil2	IDA		Zfish	PMID:18833190|ZFIN:ZDB-PUB-081008-11
Molecular Function	GO:0034584	piRNA binding	piwil2	IDA		Zfish	PMID:21743441
Molecular Function	GO:1905538	polysome binding	Piwil2	IDA		Mouse	MGI:MGI:3842880|PMID:19114715
Molecular Function	GO:0005515	protein binding	PIWIL2	IPI	UniProtKB:O00327	Human	PMID:28903391
Molecular Function	GO:0005515	protein binding	PIWIL2	IPI	UniProtKB:O15516	Human	PMID:28903391
Molecular Function	GO:0005515	protein binding	Piwil2	IPI	UniProtKB:Q99MV5	Mouse	MGI:MGI:4457263|PMID:20547853
Molecular Function	GO:0005515	protein binding	Piwil2	IPI	UniProtKB:O08785|UniProtKB:Q9WTL8|UniProtKB:Q9WV60	Mouse	MGI:MGI:6285118|PMID:28903391
Molecular Function	GO:0005515	protein binding	Piwil2	IPI	UniProtKB:P23116|UniProtKB:Q80XI3	Mouse	MGI:MGI:3842880|PMID:19114715
Molecular Function	GO:0005515	protein binding	Piwil2	IPI	UniProtKB:Q14DK4	Mouse	MGI:MGI:5825421|PMID:23611983
Molecular Function	GO:0005515	protein binding	Piwil2	IPI	UniProtKB:F8VPN2	Mouse	MGI:MGI:6434559|PMID:32381626
Molecular Function	GO:0005515	protein binding	Piwil2	IPI	UniProtKB:Q99MV1	Mouse	MGI:MGI:4356231|PMID:19465913
Molecular Function	GO:0005515	protein binding	Piwil2	IPI	UniProtKB:P61407	Mouse	MGI:MGI:3847167|PMID:19345099
Molecular Function	GO:0005515	protein binding	Piwil2	IPI	UniProtKB:Q99MV5	Mouse	MGI:MGI:4457283|PMID:20534472
Molecular Function	GO:0005515	protein binding	Piwil2	IPI	UniProtKB:Q99MV2|UniProtKB:Q9D5S1	Mouse	MGI:MGI:5908497|PMID:28254886
Molecular Function	GO:0005515	protein binding	Piwil2	IPI	PR:Q8BVN9	Mouse	PMID:16787967
Molecular Function	GO:0005515	protein binding	piwil2	IPI	UniProtKB:Q58EK5	Zfish	PMID:21743441|ZFIN:ZDB-PUB-110713-60
Molecular Function	GO:0005515	protein binding	piwil2	IPI	ZFIN:ZDB-GENE-990603-8	Zfish	PMID:20007318
Molecular Function	GO:0004521	RNA endonuclease activity	Piwil2	IDA		Mouse	MGI:MGI:5908740|PMID:28633017
Molecular Function	GO:0004521	RNA endonuclease activity	Piwil2	IMP		Mouse	MGI:MGI:5319753|PMID:22020280
Molecular Function	GO:0004521	RNA endonuclease activity	Piwil2	IMP		Mouse	MGI:MGI:5501381|PMID:23706823
Cellular Component	GO:0033391	chromatoid body	Piwil2	IDA		Mouse	MGI:MGI:3842880|PMID:19114715
Cellular Component	GO:0033391	chromatoid body	Piwil2	IDA		Mouse	PMID:21539824
Cellular Component	GO:0005737	cytoplasm	PIWIL2	IDA		Human	PMID:28025795
Cellular Component	GO:0005737	cytoplasm	Piwil2	IDA		Mouse	MGI:MGI:6434559|PMID:32381626
Cellular Component	GO:0005737	cytoplasm	Piwil2	IDA		Mouse	MGI:MGI:3842880|PMID:19114715
Cellular Component	GO:0005737	cytoplasm	Piwil2	IDA		Mouse	PMID:20014101
Cellular Component	GO:0005737	cytoplasm	Piwil2	IDA		Mouse	PMID:21539824
Cellular Component	GO:0005737	cytoplasm	piwil2	IDA		Zfish	PMID:18833190|ZFIN:ZDB-PUB-081008-11
Cellular Component	GO:0097433	dense body	Piwil2	IDA		Mouse	PMID:21539824
Cellular Component	GO:0005634	nucleus	PIWIL2	IDA		Human	PMID:28025795
Cellular Component	GO:0005634	nucleus	Piwil2	IDA		Mouse	PMID:27856912
Cellular Component	GO:0005634	nucleus	piwil2	IDA		Zfish	PMID:18833190|ZFIN:ZDB-PUB-081008-11
Cellular Component	GO:0005634	nucleus	piwil2	IDA		Zfish	PMID:20007318
Cellular Component	GO:0043186	P granule	Piwil2	IDA		Mouse	MGI:MGI:4443217|PMID:20439430
Cellular Component	GO:0043186	P granule	Piwil2	IDA		Mouse	MGI:MGI:3815367|PMID:18922463
Cellular Component	GO:0043186	P granule	piwil2	IDA		Zfish	PMID:17418787
Cellular Component	GO:0010370	perinucleolar chromocenter	Piwil2	IDA		Mouse	PMID:21539824
Cellular Component	GO:1990923	PET complex	Piwil2	IDA		Mouse	MGI:MGI:5751619|PMID:26669262
Cellular Component	GO:0071546	pi-body	Piwil2	IDA		Mouse	MGI:MGI:4417983|PMID:20011505
Cellular Component	GO:0071546	pi-body	Piwil2	IDA		Mouse	MGI:MGI:4418580|PMID:20059948
Cellular Component	GO:0071546	pi-body	Piwil2	IDA		Mouse	MGI:MGI:4356194|PMID:19730684
Biological Process	GO:0043046	DNA methylation involved in gamete generation	Piwil2	IMP		Mouse	MGI:MGI:3815367|PMID:18922463
Biological Process	GO:0043046	DNA methylation involved in gamete generation	Piwil2	IMP		Mouse	MGI:MGI:3778312|PMID:18381894
Biological Process	GO:0007276	gamete generation	piwil2	IMP		Zfish	PMID:18833190|ZFIN:ZDB-PUB-081008-11
Biological Process	GO:0030718	germ-line stem cell population maintenance	Piwil2	IMP		Mouse	MGI:MGI:3842880|PMID:19114715
Biological Process	GO:0030718	germ-line stem cell population maintenance	piwil2	IMP		Zfish	PMID:18833190|ZFIN:ZDB-PUB-081008-11
Biological Process	GO:0051321	meiotic cell cycle	piwil2	IMP		Zfish	PMID:18833190|ZFIN:ZDB-PUB-081008-11
Biological Process	GO:0042754	negative regulation of circadian rhythm	PIWIL2	IMP		Human	PMID:28903391
Biological Process	GO:0042754	negative regulation of circadian rhythm	Piwil2	IMP		Mouse	MGI:MGI:6285118|PMID:28903391
Biological Process	GO:0010991	negative regulation of SMAD protein complex assembly	piwil2	IPI	ZFIN:ZDB-GENE-990603-8	Zfish	PMID:20007318
Biological Process	GO:0010529	negative regulation of transposition	Piwil2	IMP		Mouse	MGI:MGI:5319753|PMID:22020280
Biological Process	GO:0010529	negative regulation of transposition	Piwil2	IMP		Mouse	MGI:MGI:5501381|PMID:23706823
Biological Process	GO:0048477	oogenesis	Piwil2	IEP		Mouse	MGI:MGI:3790546|PMID:18404146
Biological Process	GO:0000239	pachytene	Piwil2	IMP	MGI:MGI:3029596	Mouse	PMID:21539824
Biological Process	GO:0000239	pachytene	Piwil2	IGI	MGI:MGI:1928897	Mouse	PMID:21539824
Biological Process	GO:0034587	piRNA processing	Piwil2	IMP		Mouse	MGI:MGI:3778312|PMID:18381894
Biological Process	GO:0034587	piRNA processing	Piwil2	IDA		Mouse	MGI:MGI:3709799|PMID:17446352
Biological Process	GO:0034587	piRNA processing	Piwil2	IDA		Mouse	MGI:MGI:5751619|PMID:26669262
Biological Process	GO:0034587	piRNA processing	Piwil2	IDA		Mouse	MGI:MGI:5908740|PMID:28633017
Biological Process	GO:0034587	piRNA processing	Piwil2	IMP		Mouse	MGI:MGI:5319753|PMID:22020280
Biological Process	GO:0034587	piRNA processing	Piwil2	IMP		Mouse	MGI:MGI:5501381|PMID:23706823
Biological Process	GO:0034587	piRNA processing	Piwil2	IDA		Mouse	MGI:MGI:3815367|PMID:18922463
Biological Process	GO:0034587	piRNA processing	Piwil2	IDA		Mouse	MGI:MGI:3843431|PMID:16751777
Biological Process	GO:0034587	piRNA processing	piwil2	IDA		Zfish	PMID:18833190|ZFIN:ZDB-PUB-081008-11
Biological Process	GO:0010628	positive regulation of gene expression	piwil2	IGI	ZFIN:ZDB-GENE-990415-72,ZFIN:ZDB-MRPHLNO-100524-3	Zfish	PMID:20814180
Biological Process	GO:0060903	positive regulation of meiosis I	Piwil2	IMP	MGI:MGI:3029596	Mouse	PMID:14736746
Biological Process	GO:0045727	positive regulation of translation	Piwil2	IMP		Mouse	MGI:MGI:3842880|PMID:19114715
Biological Process	GO:0000966	RNA 5'-end processing	Piwil2	IDA		Mouse	MGI:MGI:3709799|PMID:17446352
Biological Process	GO:0031047	RNA-mediated gene silencing	Piwil2	IMP		Mouse	MGI:MGI:3815367|PMID:18922463
Biological Process	GO:0031047	RNA-mediated gene silencing	Piwil2	IMP		Mouse	MGI:MGI:3778312|PMID:18381894
Biological Process	GO:0031047	RNA-mediated gene silencing	Piwil2	IMP		Mouse	MGI:MGI:3709799|PMID:17446352
Biological Process	GO:0007283	spermatogenesis	Piwil2	IMP		Mouse	MGI:MGI:5501381|PMID:23706823
Biological Process	GO:0007283	spermatogenesis	Piwil2	IMP		Mouse	MGI:MGI:5319753|PMID:22020280
Biological Process	GO:0007283	spermatogenesis	Piwil2	IMP		Mouse	MGI:MGI:3778312|PMID:18381894

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern