Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIWIL4
  • Mouse genes Piwil4
  • Rat genes Piwil4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Piwil4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034584	piRNA binding	PIWIL4	IDA		Human	PMID:25038252
Molecular Function	GO:0034584	piRNA binding	Piwil4	IDA		Mouse	MGI:MGI:3815367|PMID:18922463
Molecular Function	GO:0005515	protein binding	Piwil4	IPI	UniProtKB:Q14BI7	Mouse	MGI:MGI:4418580|PMID:20059948
Molecular Function	GO:0005515	protein binding	Piwil4	IPI	UniProtKB:Q80VL1	Mouse	MGI:MGI:5494327|PMID:23714778
Molecular Function	GO:0005515	protein binding	Piwil4	IPI	UniProtKB:B1ASB6	Mouse	MGI:MGI:6453929|PMID:32674113
Molecular Function	GO:0005515	protein binding	Piwil4	IPI	UniProtKB:Q99MV5	Mouse	MGI:MGI:4457283|PMID:20534472
Molecular Function	GO:0005515	protein binding	Piwil4	IPI	UniProtKB:F8VPN2	Mouse	MGI:MGI:6447460|PMID:32719317
Molecular Function	GO:0005515	protein binding	Piwil4	IPI	UniProtKB:Q99MV5	Mouse	MGI:MGI:4457263|PMID:20547853
Molecular Function	GO:0005515	protein binding	Piwil4	IPI	UniProtKB:Q8BVN9	Mouse	MGI:MGI:3655410|PMID:16787967
Cellular Component	GO:0005737	cytoplasm	PIWIL4	IDA		Human	PMID:28025795
Cellular Component	GO:0005737	cytoplasm	Piwil4	IDA		Mouse	MGI:MGI:3815367|PMID:18922463
Cellular Component	GO:0005739	mitochondrion	PIWIL4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PIWIL4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PIWIL4	IDA		Human	PMID:28025795
Cellular Component	GO:0005634	nucleus	Piwil4	IDA		Mouse	MGI:MGI:3815367|PMID:18922463
Cellular Component	GO:0005634	nucleus	Piwil4	IDA		Mouse	MGI:MGI:6453929|PMID:32674113
Cellular Component	GO:0005634	nucleus	Piwil4	IDA		Mouse	MGI:MGI:6434559|PMID:32381626
Cellular Component	GO:0005634	nucleus	Piwil4	IDA		Mouse	MGI:MGI:6447460|PMID:32719317
Cellular Component	GO:0043186	P granule	Piwil4	IDA		Mouse	MGI:MGI:3815367|PMID:18922463
Cellular Component	GO:0071547	piP-body	Piwil4	IDA		Mouse	MGI:MGI:4418580|PMID:20059948
Cellular Component	GO:0071547	piP-body	Piwil4	IDA		Mouse	MGI:MGI:4417983|PMID:20011505
Biological Process	GO:0043046	DNA methylation involved in gamete generation	Piwil4	IMP		Mouse	MGI:MGI:3815367|PMID:18922463
Biological Process	GO:0043046	DNA methylation involved in gamete generation	Piwil4	IMP		Mouse	MGI:MGI:3778312|PMID:18381894
Biological Process	GO:0010669	epithelial structure maintenance	PIWIL4	IMP		Human	PMID:28025795
Biological Process	GO:0010529	negative regulation of transposition	Piwil4	IMP		Mouse	MGI:MGI:5319753|PMID:22020280
Biological Process	GO:0010529	negative regulation of transposition	Piwil4	IMP	MGI:MGI:3712153	Mouse	PMID:25503965
Biological Process	GO:0034587	piRNA processing	Piwil4	IDA		Mouse	MGI:MGI:3815367|PMID:18922463
Biological Process	GO:0034587	piRNA processing	Piwil4	IDA		Mouse	MGI:MGI:5751619|PMID:26669262
Biological Process	GO:0034587	piRNA processing	Piwil4	IMP		Mouse	MGI:MGI:3778312|PMID:18381894
Biological Process	GO:0034587	piRNA processing	Piwil4	IMP		Mouse	MGI:MGI:5319753|PMID:22020280
Biological Process	GO:0034587	piRNA processing	Piwil4	IMP		Mouse	MGI:MGI:3708051|PMID:17395546
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	Piwil4	IMP		Rat	PMID:28711973|RGD:13800537
Biological Process	GO:0031047	RNA-mediated gene silencing	Piwil4	IMP		Mouse	MGI:MGI:3815367|PMID:18922463
Biological Process	GO:0031047	RNA-mediated gene silencing	Piwil4	IMP		Mouse	MGI:MGI:3708051|PMID:17395546
Biological Process	GO:0031047	RNA-mediated gene silencing	Piwil4	IMP		Mouse	MGI:MGI:3778312|PMID:18381894
Biological Process	GO:0007283	spermatogenesis	Piwil4	IMP		Mouse	MGI:MGI:3708051|PMID:17395546
Biological Process	GO:0007283	spermatogenesis	Piwil4	IMP		Mouse	MGI:MGI:5319753|PMID:22020280
Biological Process	GO:0007283	spermatogenesis	Piwil4	IMP		Mouse	MGI:MGI:3778312|PMID:18381894
Biological Process	GO:0007283	spermatogenesis	Piwil4	IMP	MGI:MGI:3712153	Mouse	PMID:25503965

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern