Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PKD1
  • Mouse genes Pkd1
  • Rat genes Pkd1
  • Zfish genes pkd1a,pkd1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pkd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005262	calcium channel activity	PKD1	IDA		Human	PMID:27214281
Molecular Function	GO:0005262	calcium channel activity	Pkd1	IMP		Mouse	MGI:MGI:2449360|PMID:12514735
Molecular Function	GO:0005261	monoatomic cation channel activity	Pkd1	IPI	PR:A2A259	Mouse	PMID:15548533
Molecular Function	GO:0005515	protein binding	PKD1	IPI	UniProtKB:Q13563	Human	PMID:10097141
Molecular Function	GO:0005515	protein binding	PKD1	IPI	UniProtKB:P46561	Human	PMID:15563610
Molecular Function	GO:0005515	protein binding	PKD1	IPI	UniProtKB:Q13563-1	Human	PMID:19556541
Molecular Function	GO:0005515	protein binding	PKD1	IPI	UniProtKB:Q13563	Human	PMID:20168298
Molecular Function	GO:0005515	protein binding	PKD1	IPI	UniProtKB:O15259	Human	PMID:20856870
Molecular Function	GO:0005515	protein binding	PKD1	IPI	UniProtKB:Q8TAM2	Human	PMID:24939912
Molecular Function	GO:0005515	protein binding	Pkd1	IPI	UniProtKB:O35245|UniProtKB:O35551	Mouse	MGI:MGI:6210198|PMID:25405894
Molecular Function	GO:0005515	protein binding	Pkd1	IPI	UniProtKB:Q8BHC7	Mouse	MGI:MGI:5437551|PMID:22795130
Molecular Function	GO:0005515	protein binding	Pkd1	IPI	UniProtKB:Q13563-1	Mouse	MGI:MGI:5914982|PMID:21642537
Molecular Function	GO:0005515	protein binding	Pkd1	IPI	PR:O35245	Mouse	PMID:12007403
Molecular Function	GO:0005515	protein binding	Pkd1	IPI	PR:A2A259	Mouse	PMID:15548533
Molecular Function	GO:0005515	protein binding	Pkd1	IPI	PR:O35245	Mouse	PMID:11901144
Molecular Function	GO:0019904	protein domain specific binding	PKD1	IPI	UniProtKB:Q13563	Human	PMID:9171830
Molecular Function	GO:0019901	protein kinase binding	PKD1	IPI	UniProtKB:P51817	Human	PMID:17980165
Molecular Function	GO:0044325	transmembrane transporter binding	PKD1	IPI	UniProtKB:Q13563	Human	PMID:9192675
Molecular Function	GO:0042813	Wnt receptor activity	PKD1	IDA		Human	PMID:27214281
Cellular Component	GO:0016323	basolateral plasma membrane	PKD1	IDA		Human	PMID:10770959
Cellular Component	GO:0034704	calcium channel complex	PKD1	IDA		Human	PMID:27214281
Cellular Component	GO:0034703	cation channel complex	PKD1	IDA		Human	PMID:30093605
Cellular Component	GO:0009986	cell surface	Pkd1	IDA		Mouse	MGI:MGI:5603942|PMID:24939912
Cellular Component	GO:0005929	cilium	PKD1	IDA		Human	PMID:28154160
Cellular Component	GO:0005929	cilium	Pkd1	IDA		Mouse	MGI:MGI:6210198|PMID:25405894
Cellular Component	GO:0005929	cilium	Pkd1	IDA		Mouse	MGI:MGI:5603942|PMID:24939912
Cellular Component	GO:0005929	cilium	Pkd1	IDA		Mouse	PMID:18285569
Cellular Component	GO:0005929	cilium	Pkd1	IDA		Mouse	PMID:12514735
Cellular Component	GO:0005737	cytoplasm	Pkd1	IMP		Mouse	MGI:MGI:5315699|PMID:16311606
Cellular Component	GO:0005783	endoplasmic reticulum	Pkd1	IDA		Mouse	MGI:MGI:6210198|PMID:25405894
Cellular Component	GO:0070062	extracellular exosome	PKD1	IDA		Human	PMID:15326289
Cellular Component	GO:0070062	extracellular exosome	PKD1	HDA		Human	PMID:19056867
Cellular Component	GO:0005794	Golgi apparatus	Pkd1	IDA		Mouse	MGI:MGI:6210198|PMID:25405894
Cellular Component	GO:0005794	Golgi apparatus	Pkd1	IDA		Rat	PMID:11336705|RGD:633539
Cellular Component	GO:0016328	lateral plasma membrane	Pkd1	IDA		Rat	PMID:11336705|RGD:633539
Cellular Component	GO:0016020	membrane	Pkd1	IDA		Rat	PMID:11336705|RGD:633539
Cellular Component	GO:0031514	motile cilium	Pkd1	IDA		Mouse	PMID:15858826
Cellular Component	GO:0005634	nucleus	Pkd1	IDA		Mouse	PMID:15545994
Cellular Component	GO:0005886	plasma membrane	PKD1	IDA		Human	PMID:23001567
Cellular Component	GO:0005886	plasma membrane	PKD1	IDA		Human	PMID:30093605
Cellular Component	GO:0005886	plasma membrane	Pkd1	IPI	UniProtKB:Q80ZH4	Mouse	PMID:15548533
Cellular Component	GO:0002133	polycystin complex	PKD1	IPI		Human	PMID:11901144
Cellular Component	GO:0002133	polycystin complex	Pkd1	IDA		Mouse	MGI:MGI:6210198|PMID:25405894
Cellular Component	GO:0002133	polycystin complex	Pkd1	IPI		Mouse	MGI:MGI:2180983|PMID:11901144
Cellular Component	GO:0002133	polycystin complex	Pkd1	IDA		Mouse	PMID:11901144
Biological Process	GO:0001568	blood vessel development	Pkd1	IMP	MGI:MGI:2183523	Mouse	PMID:10677526
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	PKD1	IDA		Human	PMID:12482949
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Pkd1	IDA		Mouse	MGI:MGI:5603942|PMID:24939912
Biological Process	GO:0070588	calcium ion transmembrane transport	Pkd1	IMP		Mouse	MGI:MGI:2449360|PMID:12514735
Biological Process	GO:0006816	calcium ion transport	PKD1	IDA		Human	PMID:27214281
Biological Process	GO:0006816	calcium ion transport	Pkd1	IDA		Mouse	MGI:MGI:2449360|PMID:12514735
Biological Process	GO:0006816	calcium ion transport	Pkd1	IMP	MGI:MGI:1857562	Mouse	PMID:12514735
Biological Process	GO:0001502	cartilage condensation	Pkd1	IMP	MGI:MGI:2152589	Mouse	PMID:11593033
Biological Process	GO:0051216	cartilage development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0098609	cell-cell adhesion	Pkd1	IMP	MGI:MGI:2183523	Mouse	PMID:10677526
Biological Process	GO:0198738	cell-cell signaling by wnt	PKD1	IDA		Human	PMID:27214281
Biological Process	GO:0042994	cytoplasmic sequestering of transcription factor	Pkd1	IMP		Mouse	MGI:MGI:5315699|PMID:16311606
Biological Process	GO:0050982	detection of mechanical stimulus	Pkd1	IDA		Mouse	PMID:15545994
Biological Process	GO:0050982	detection of mechanical stimulus	Pkd1	IMP	MGI:MGI:1857562	Mouse	PMID:12514735
Biological Process	GO:0048565	digestive tract development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0001892	embryonic placenta development	Pkd1	IMP		Mouse	MGI:MGI:4836293|PMID:20862291
Biological Process	GO:0090162	establishment of epithelial cell polarity	Pkd1	IMP	MGI:MGI:3612341	Mouse	PMID:24767999
Biological Process	GO:0048806	genitalia development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0007507	heart development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0007507	heart development	Pkd1	IMP	MGI:MGI:2152589	Mouse	PMID:11593033
Biological Process	GO:0007507	heart development	Pkd1	IMP		Mouse	PMID:25807483
Biological Process	GO:0001701	in utero embryonic development	Pkd1	IGI	MGI:MGI:1197519	Mouse	PMID:16282979
Biological Process	GO:0001701	in utero embryonic development	Pkd1	IMP	MGI:MGI:1857562	Mouse	PMID:16282979
Biological Process	GO:0001822	kidney development	Pkd1	IMP		Mouse	MGI:MGI:4836293|PMID:20862291
Biological Process	GO:0001822	kidney development	Pkd1	IGI	MGI:MGI:1099818	Mouse	PMID:21685914
Biological Process	GO:0001822	kidney development	Pkd1	IMP	MGI:MGI:5438059	Mouse	PMID:27002738
Biological Process	GO:0001822	kidney development	Pkd1	IMP		Mouse	PMID:21518438
Biological Process	GO:0001889	liver development	Pkd1	IGI	MGI:MGI:1099818	Mouse	PMID:21685914
Biological Process	GO:0001889	liver development	pkd1a	IMP	ZFIN:ZDB-MRPHLNO-100707-1	Zfish	PMID:23668934
Biological Process	GO:0060428	lung epithelium development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0036303	lymph vessel morphogenesis	Pkd1	IMP	MGI:MGI:3612341	Mouse	PMID:24767999
Biological Process	GO:0001946	lymphangiogenesis	pkd1a	IGI	ZFIN:ZDB-GENO-140801-1,ZFIN:ZDB-MRPHLNO-100707-3	Zfish	PMID:24767999
Biological Process	GO:0001946	lymphangiogenesis	pkd1a	IMP	ZFIN:ZDB-GENO-140801-1	Zfish	PMID:24767999
Biological Process	GO:0001946	lymphangiogenesis	pkd1b	IGI	ZFIN:ZDB-GENO-140801-1,ZFIN:ZDB-MRPHLNO-100707-3	Zfish	PMID:24767999
Biological Process	GO:0072177	mesonephric duct development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0072164	mesonephric tubule development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0072218	metanephric ascending thin limb development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0072205	metanephric collecting duct development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0072287	metanephric distal tubule morphogenesis	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0072237	metanephric proximal tubule development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0021915	neural tube development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0006807	nitrogen compound metabolic process	Pkd1	IGI	MGI:MGI:2155302	Mouse	PMID:21685914
Biological Process	GO:0006807	nitrogen compound metabolic process	Pkd1	IGI	MGI:MGI:107877	Mouse	PMID:21685914
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Pkd1	IMP		Mouse	MGI:MGI:4440396|PMID:20181743
Biological Process	GO:0060674	placenta blood vessel development	Pkd1	IMP		Mouse	MGI:MGI:4836293|PMID:20862291
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	PKD1	IDA		Human	PMID:16311606
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Pkd1	IMP		Rat	PMID:16952559|RGD:7175288
Biological Process	GO:0032092	positive regulation of protein binding	Pkd1	IMP		Mouse	MGI:MGI:5315699|PMID:16311606
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PKD1	IDA		Human	PMID:16311606
Biological Process	GO:0048793	pronephros development	pkd1a	IMP	ZFIN:ZDB-GENO-180912-9	Zfish	PMID:28007903
Biological Process	GO:0006611	protein export from nucleus	Pkd1	IMP		Mouse	MGI:MGI:4440396|PMID:20181743
Biological Process	GO:0051290	protein heterotetramerization	PKD1	IDA		Human	PMID:30093605
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Pkd1	EXP		Mouse	MGI:MGI:2178492|PMID:12007403
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Pkd1	IDA		Mouse	PMID:12007403
Biological Process	GO:0030155	regulation of cell adhesion	Pkd1	IMP	MGI:MGI:3612341	Mouse	PMID:24767999
Biological Process	GO:0051726	regulation of cell cycle	Pkd1	IDA		Mouse	PMID:12007403
Biological Process	GO:0032965	regulation of collagen biosynthetic process	pkd1a	IGI	ZFIN:ZDB-MRPHLNO-100707-2,ZFIN:ZDB-MRPHLNO-100707-3	Zfish	PMID:20335443
Biological Process	GO:0032965	regulation of collagen biosynthetic process	pkd1b	IGI	ZFIN:ZDB-MRPHLNO-100707-2,ZFIN:ZDB-MRPHLNO-100707-3	Zfish	PMID:20335443
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	PKD1	IDA		Human	PMID:16311606
Biological Process	GO:0060236	regulation of mitotic spindle organization	Pkd1	IMP	MGI:MGI:3793793	Mouse	PMID:21685914
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	PKD1	IDA		Human	PMID:23001567
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	Pkd1	IMP	MGI:MGI:1857562	Mouse	PMID:23001567
Biological Process	GO:0034405	response to fluid shear stress	Pkd1	IMP	MGI:MGI:2182840	Mouse	PMID:18285569
Biological Process	GO:0043588	skin development	PKD1	IEP		Human	PMID:11891195
Biological Process	GO:0021510	spinal cord development	PKD1	IEP		Human	PMID:11891195

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern