Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PKD2L1
  • Mouse genes Pkd2l1
  • Rat genes Pkd2l1
  • Zfish genes pkd2l1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pkd2l1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051393	alpha-actinin binding	PKD2L1	IPI	UniProtKB:P12814	Human	PMID:17944866
Molecular Function	GO:0005227	calcium activated cation channel activity	PKD2L1	IDA		Human	PMID:10517637
Molecular Function	GO:0005227	calcium activated cation channel activity	PKD2L1	IDA		Human	PMID:11959145
Molecular Function	GO:0005262	calcium channel activity	PKD2L1	IDA		Human	PMID:24336289
Molecular Function	GO:0005262	calcium channel activity	Pkd2l1	IMP		Mouse	MGI:MGI:5559921|PMID:24336288
Molecular Function	GO:0005509	calcium ion binding	PKD2L1	IDA		Human	PMID:22193359
Molecular Function	GO:0005509	calcium ion binding	Pkd2l1	IDA		Mouse	MGI:MGI:5315681|PMID:20408813
Molecular Function	GO:0015269	calcium-activated potassium channel activity	PKD2L1	IDA		Human	PMID:10517637
Molecular Function	GO:0008092	cytoskeletal protein binding	PKD2L1	IPI	UniProtKB:P19429	Human	PMID:12809519
Molecular Function	GO:0042802	identical protein binding	Pkd2l1	IPI	UniProtKB:A2A259	Mouse	MGI:MGI:5315344|PMID:16891422
Molecular Function	GO:0042802	identical protein binding	Pkd2l1	IPI	UniProtKB:A2A259	Mouse	MGI:MGI:5315681|PMID:20408813
Molecular Function	GO:0005261	monoatomic cation channel activity	PKD2L1	IDA		Human	PMID:17944866
Molecular Function	GO:0005261	monoatomic cation channel activity	PKD2L1	IDA		Human	PMID:30004384
Molecular Function	GO:0005261	monoatomic cation channel activity	Pkd2l1	IDA		Mouse	MGI:MGI:5315344|PMID:16891422
Molecular Function	GO:0005261	monoatomic cation channel activity	Pkd2l1	IDA		Mouse	MGI:MGI:6245961|PMID:28904867
Molecular Function	GO:0005261	monoatomic cation channel activity	Pkd2l1	IPI	PR:O08852	Mouse	PMID:15548533
Molecular Function	GO:0008324	monoatomic cation transmembrane transporter activity	Pkd2l1	IDA		Mouse	MGI:MGI:5315344|PMID:16891422
Molecular Function	GO:0051371	muscle alpha-actinin binding	PKD2L1	IPI	UniProtKB:P35609	Human	PMID:17944866
Molecular Function	GO:0005515	protein binding	PKD2L1	IPI	UniProtKB:P19429	Human	PMID:12525172
Molecular Function	GO:0005515	protein binding	PKD2L1	IPI	UniProtKB:Q7Z443	Human	PMID:20538909
Molecular Function	GO:0005515	protein binding	PKD2L1	IPI	UniProtKB:Q8TDX9	Human	PMID:24336289
Molecular Function	GO:0005515	protein binding	PKD2L1	IPI	UniProtKB:Q8N6F1-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	Pkd2l1	IPI	UniProtKB:Q2EG98	Mouse	MGI:MGI:5315344|PMID:16891422
Molecular Function	GO:0005515	protein binding	Pkd2l1	IPI	PR:O08852	Mouse	PMID:15548533
Molecular Function	GO:0005272	sodium channel activity	PKD2L1	IDA		Human	PMID:10517637
Molecular Function	GO:0033040	sour taste receptor activity	Pkd2l1	IDA		Mouse	MGI:MGI:5315344|PMID:16891422
Cellular Component	GO:0015629	actin cytoskeleton	PKD2L1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0034704	calcium channel complex	PKD2L1	IDA		Human	PMID:24336289
Cellular Component	GO:0034704	calcium channel complex	Pkd2l1	IDA		Mouse	MGI:MGI:6149416|PMID:29567962
Cellular Component	GO:0034704	calcium channel complex	Pkd2l1	IMP		Mouse	MGI:MGI:5559921|PMID:24336288
Cellular Component	GO:0034703	cation channel complex	Pkd2l1	IDA		Mouse	MGI:MGI:5315344|PMID:16891422
Cellular Component	GO:0009986	cell surface	Pkd2l1	IDA		Mouse	MGI:MGI:5315344|PMID:16891422
Cellular Component	GO:0005829	cytosol	PKD2L1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	Pkd2l1	IDA		Mouse	PMID:15548533
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PKD2L1	IDA		Human	PMID:17944866
Cellular Component	GO:0016020	membrane	PKD2L1	IDA		Human	PMID:19812697
Cellular Component	GO:0097730	non-motile cilium	PKD2L1	IDA		Human	PMID:24336289
Cellular Component	GO:0005886	plasma membrane	PKD2L1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PKD2L1	IMP		Human	PMID:17944866
Cellular Component	GO:0005886	plasma membrane	PKD2L1	IDA		Human	PMID:20538909
Cellular Component	GO:0005886	plasma membrane	Pkd2l1	IDA		Mouse	MGI:MGI:6245961|PMID:28904867
Cellular Component	GO:0005886	plasma membrane	Pkd2l1	IDA		Mouse	MGI:MGI:6149416|PMID:29567962
Cellular Component	GO:0005886	plasma membrane	Pkd2l1	IPI	PR:O08852	Mouse	PMID:15548533
Cellular Component	GO:0043235	receptor complex	Pkd2l1	IDA		Mouse	MGI:MGI:5315344|PMID:16891422
Biological Process	GO:0071468	cellular response to acidic pH	Pkd2l1	IDA		Mouse	MGI:MGI:6149416|PMID:29567962
Biological Process	GO:0071468	cellular response to acidic pH	Pkd2l1	IDA		Mouse	MGI:MGI:5315344|PMID:16891422
Biological Process	GO:0071467	cellular response to pH	Pkd2l1	IDA		Mouse	MGI:MGI:6245961|PMID:28904867
Biological Process	GO:0001581	detection of chemical stimulus involved in sensory perception of sour taste	Pkd2l1	IDA		Mouse	MGI:MGI:5315344|PMID:16891422
Biological Process	GO:0050912	detection of chemical stimulus involved in sensory perception of taste	Pkd2l1	IMP		Mouse	MGI:MGI:5912987|PMID:28553944
Biological Process	GO:0098662	inorganic cation transmembrane transport	PKD2L1	IDA		Human	PMID:30004384
Biological Process	GO:0098662	inorganic cation transmembrane transport	Pkd2l1	IDA		Mouse	MGI:MGI:6245961|PMID:28904867
Biological Process	GO:0007638	mechanosensory behavior	pkd2l1	IMP	ZFIN:ZDB-GENO-160811-6	Zfish	PMID:26946992
Biological Process	GO:0006812	monoatomic cation transport	Pkd2l1	IDA		Mouse	MGI:MGI:5315344|PMID:16891422
Biological Process	GO:0071805	potassium ion transmembrane transport	PKD2L1	IDA		Human	PMID:10517637
Biological Process	GO:0051289	protein homotetramerization	PKD2L1	IDA		Human	PMID:30004384
Biological Process	GO:0051262	protein tetramerization	Pkd2l1	IDA		Mouse	MGI:MGI:6149416|PMID:29567962
Biological Process	GO:0009612	response to mechanical stimulus	pkd2l1	IMP	ZFIN:ZDB-GENO-160811-6	Zfish	PMID:26946992
Biological Process	GO:0009415	response to water	Pkd2l1	IMP		Mouse	MGI:MGI:5912987|PMID:28553944
Biological Process	GO:0050915	sensory perception of sour taste	PKD2L1	IMP		Human	PMID:19812697
Biological Process	GO:0007224	smoothened signaling pathway	Pkd2l1	IMP		Mouse	MGI:MGI:5559921|PMID:24336288
Biological Process	GO:0035725	sodium ion transmembrane transport	PKD2L1	IDA		Human	PMID:10517637

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern