Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PKHD1
  • Mouse genes Pkhd1
  • Rat genes Pkhd1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pkhd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PKHD1	IPI	UniProtKB:P49069	Human	PMID:16243292
Molecular Function	GO:0005515	protein binding	PKHD1	IPI	UniProtKB:Q13563	Human	PMID:18235088
Molecular Function	GO:0005515	protein binding	PKHD1	IPI	UniProtKB:P55258	Human	PMID:20048263
Molecular Function	GO:0005515	protein binding	PKHD1	IPI	UniProtKB:P07602	Human	PMID:20709014
Molecular Function	GO:0005515	protein binding	Pkhd1	IPI	UniProtKB:P49069	Mouse	MGI:MGI:3608147|PMID:16243292
Molecular Function	GO:0005515	protein binding	Pkhd1	IPI	PR:O35245	Mouse	PMID:18235088
Molecular Function	GO:0005515	protein binding	Pkhd1	IPI	UniProtKB:O75386	Mouse	PMID:28154160
Molecular Function	GO:0005515	protein binding	Pkhd1	IPI	PR:P61750	Mouse	PMID:24586199
Cellular Component	GO:0097731	9+0 non-motile cilium	Pkhd1	IDA		Mouse	PMID:24586199
Cellular Component	GO:0016324	apical plasma membrane	PKHD1	IDA		Human	PMID:16243292
Cellular Component	GO:0016324	apical plasma membrane	Pkhd1	IDA		Mouse	MGI:MGI:3773566|PMID:18202188
Cellular Component	GO:0005813	centrosome	PKHD1	IDA		Human	PMID:20554582
Cellular Component	GO:0036064	ciliary basal body	PKHD1	IDA		Human	PMID:14978161
Cellular Component	GO:0036064	ciliary basal body	PKHD1	IDA		Human	PMID:14983006
Cellular Component	GO:0005929	cilium	PKHD1	IDA		Human	PMID:15458427
Cellular Component	GO:0005929	cilium	PKHD1	IDA		Human	PMID:16956880
Cellular Component	GO:0005929	cilium	PKHD1	IDA		Human	PMID:17470460
Cellular Component	GO:0005929	cilium	PKHD1	IMP		Human	PMID:20048263
Cellular Component	GO:0005929	cilium	Pkhd1	IDA		Mouse	MGI:MGI:6467716|PMID:16956880
Cellular Component	GO:0005929	cilium	Pkhd1	IDA		Mouse	MGI:MGI:3773566|PMID:18202188
Cellular Component	GO:0005929	cilium	Pkhd1	IDA		Mouse	MGI:MGI:5438087|PMID:22021705
Cellular Component	GO:0005929	cilium	Pkhd1	IDA		Mouse	MGI:MGI:6467923|PMID:17470460
Cellular Component	GO:0005929	cilium	Pkhd1	IDA		Mouse	PMID:28154160
Cellular Component	GO:0005929	cilium	Pkhd1	IDA		Rat	PMID:12925574|RGD:1642442
Cellular Component	GO:0005737	cytoplasm	PKHD1	IDA		Human	PMID:20709014
Cellular Component	GO:0005783	endoplasmic reticulum	Pkhd1	IDA		Mouse	MGI:MGI:6467694|PMID:28729032
Cellular Component	GO:0070062	extracellular exosome	PKHD1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	Pkhd1	IDA		Mouse	MGI:MGI:5438087|PMID:22021705
Cellular Component	GO:0005794	Golgi apparatus	Pkhd1	IDA		Mouse	MGI:MGI:6467694|PMID:28729032
Cellular Component	GO:0016020	membrane	Pkhd1	IDA		Rat	PMID:16677351|RGD:1642437
Cellular Component	GO:0072686	mitotic spindle	PKHD1	IDA		Human	PMID:20554582
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PKHD1	IDA		Human	PMID:20709014
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Pkhd1	IMP		Mouse	MGI:MGI:4880601|PMID:20875407
Biological Process	GO:0045216	cell-cell junction organization	Pkhd1	IMP		Mouse	MGI:MGI:4880601|PMID:20875407
Biological Process	GO:0060271	cilium assembly	Pkhd1	IMP	MGI:MGI:3826780	Mouse	PMID:18235088
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Pkhd1	IMP		Mouse	MGI:MGI:5430302|PMID:19959710
Biological Process	GO:0006874	intracellular calcium ion homeostasis	PKHD1	IMP		Human	PMID:17669261
Biological Process	GO:0001822	kidney development	Pkhd1	IDA		Mouse	PMID:15067314
Biological Process	GO:0043066	negative regulation of apoptotic process	PKHD1	IMP		Human	PMID:19943112
Biological Process	GO:0043066	negative regulation of apoptotic process	PKHD1	IMP		Human	PMID:21300060
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Pkhd1	IMP		Mouse	MGI:MGI:4880601|PMID:20875407
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PKHD1	IMP		Human	PMID:21300060
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PKHD1	IMP		Human	PMID:21300060
Biological Process	GO:0008284	positive regulation of cell population proliferation	PKHD1	IMP		Human	PMID:19943112
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Pkhd1	IMP		Mouse	MGI:MGI:4880601|PMID:20875407
Biological Process	GO:0010824	regulation of centrosome duplication	PKHD1	IMP		Human	PMID:20554582
Biological Process	GO:1904054	regulation of cholangiocyte proliferation	PKHD1	IMP		Human	PMID:30898581
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	PKHD1	IMP		Human	PMID:17669261
Biological Process	GO:0090175	regulation of establishment of planar polarity	Pkhd1	IMP		Mouse	MGI:MGI:5430302|PMID:19959710
Biological Process	GO:0032006	regulation of TOR signaling	PKHD1	IMP		Human	PMID:19524688

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern