Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PKIA
  • Mouse genes Pkia
  • Rat genes Pkia
  • Zfish genes si:dkey-7n6.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pkia

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	PKIA	IDA		Human	PMID:21812984
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	PKIA	IDA		Human	PMID:7905001
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	Pkia	IDA		Mouse	PMID:9218452
Molecular Function	GO:0140678	molecular function inhibitor activity	PKIA	EXP		Human	PMID:26349033
Molecular Function	GO:0005515	protein binding	PKIA	IPI	UniProtKB:O14980	Human	PMID:20485264
Molecular Function	GO:0005515	protein binding	PKIA	IPI	UniProtKB:P30822	Human	PMID:20485264
Molecular Function	GO:0005515	protein binding	PKIA	IPI	UniProtKB:Q6P5F9	Human	PMID:20972448
Molecular Function	GO:0005515	protein binding	PKIA	IPI	UniProtKB:O43663	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PKIA	IPI	UniProtKB:P22694	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PKIA	IPI	UniProtKB:P55212	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PKIA	IPI	UniProtKB:P63167	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PKIA	IPI	UniProtKB:Q6NTE8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PKIA	IPI	UniProtKB:Q96FJ2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pkia	IPI	UniProtKB:P05132	Mouse	MGI:MGI:5917744|PMID:26833386
Molecular Function	GO:0005515	protein binding	Pkia	IPI	UniProtKB:P05132	Mouse	MGI:MGI:6450273|PMID:23458248
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	PKIA	IPI	UniProtKB:P17612-1	Human	PMID:21812984
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	PKIA	IPI	UniProtKB:P17612-2	Human	PMID:21812984
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	Pkia	IPI	UniProtKB:P05132	Mouse	MGI:MGI:5882923|PMID:1862342
Cellular Component	GO:0005737	cytoplasm	Pkia	IDA		Mouse	PMID:7836431
Cellular Component	GO:0005634	nucleus	Pkia	IDA		Mouse	PMID:7836431
Biological Process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	PKIA	IDA		Human	PMID:7905001
Biological Process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	PKIA	IDA		Human	PMID:21812984
Biological Process	GO:0043086	negative regulation of catalytic activity	Pkia	IDA		Mouse	PMID:7836431
Biological Process	GO:0042308	negative regulation of protein import into nucleus	Pkia	IDA		Mouse	PMID:9218452
Biological Process	GO:0006469	negative regulation of protein kinase activity	Pkia	IDA		Mouse	PMID:9218452
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Pkia	IDA		Mouse	PMID:9218452
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	Pkia	IMP		Mouse	PMID:7836431

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern