Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pkm

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PKM
- Mouse genes Pkm
- Rat genes Pkm
- Zfish genes pkma,pkmb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pkm

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	Pkm	IDA		Rat	PMID:7040662\|RGD:2303138
Molecular Function	GO:0045296	cadherin binding	PKM	HDA		Human	PMID:25468996
Molecular Function	GO:0042802	identical protein binding	Pkm	IDA		Rat	PMID:1883388\|RGD:12793012
Molecular Function	GO:0023026	MHC class II protein complex binding	PKM	HDA		Human	PMID:20458337
Molecular Function	GO:0003729	mRNA binding	Pkm	IDA		Mouse	MGI:MGI:6331015\|PMID:28575669
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:P04049	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:P32121	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:P49407	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:Q01860	Human	PMID:18191611
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:P29590	Human	PMID:18298799
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:Q9WMX2	Human	PMID:18519040
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:Q9BSI4	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:P53355	Human	PMID:21725354
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:P35222	Human	PMID:22056988
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:Q96S16	Human	PMID:27199445
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:Q8N488	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:Q96IK1-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:Q9UMX0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PKM	IPI	UniProtKB:Q9Y649	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Pkm	IPI	UniProtKB:P20263	Mouse	MGI:MGI:3773761\|PMID:18191611
Molecular Function	GO:0005515	protein binding	Pkm	IPI	UniProtKB:P26663	Mouse	MGI:MGI:5512960\|PMID:18519040
Molecular Function	GO:0005515	protein binding	Pkm	IPI	UniProtKB:P04156:PRO_0000025675	Mouse	MGI:MGI:5635350\|PMID:24390569
Molecular Function	GO:0005515	protein binding	Pkm	IPI	PR:P42859	Mouse	PMID:17500595
Molecular Function	GO:0005515	protein binding	Pkm	IPI	RGD:2617	Rat	PMID:17877381\|RGD:2302074
Molecular Function	GO:0046983	protein dimerization activity	Pkm	IDA		Rat	PMID:11687968\|RGD:152176659
Molecular Function	GO:0004743	pyruvate kinase activity	PKM	IDA		Human	PMID:20005212
Molecular Function	GO:0004743	pyruvate kinase activity	Pkm	IDA		Mouse	PMID:7295297
Molecular Function	GO:0004743	pyruvate kinase activity	Pkm	IDA		Mouse	PMID:7262549
Molecular Function	GO:0004743	pyruvate kinase activity	Pkm	IDA		Rat	PMID:10734049\|RGD:151708737
Molecular Function	GO:0004743	pyruvate kinase activity	Pkm	IDA		Rat	PMID:1883388\|RGD:12793012
Molecular Function	GO:0004743	pyruvate kinase activity	Pkm	IDA		Rat	PMID:4273555\|RGD:2302790
Molecular Function	GO:0003723	RNA binding	PKM	HDA		Human	PMID:22658674
Molecular Function	GO:0070324	thyroid hormone binding	Pkm	IDA		Rat	PMID:1883388\|RGD:12793012
Cellular Component	GO:0005929	cilium	Pkm	IDA		Mouse	PMID:16687649
Cellular Component	GO:0062023	collagen-containing extracellular matrix	PKM	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Pkm	HDA		Mouse	MGI:MGI:5582867\|PMID:23658023
Cellular Component	GO:0005737	cytoplasm	PKM	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005737	cytoplasm	PKM	IDA		Human	PMID:18298799
Cellular Component	GO:0005829	cytosol	PKM	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Pkm	IDA		Mouse	PMID:25565206
Cellular Component	GO:0070062	extracellular exosome	PKM	HDA		Human	PMID:11487543
Cellular Component	GO:0070062	extracellular exosome	PKM	HDA		Human	PMID:12519789
Cellular Component	GO:0070062	extracellular exosome	PKM	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	PKM	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	PKM	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	PKM	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	PKM	HDA		Human	PMID:23533145
Cellular Component	GO:1903561	extracellular vesicle	PKM	HDA		Human	PMID:24769233
Cellular Component	GO:0005739	mitochondrion	PKM	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Pkm	HDA		Mouse	PMID:14651853
Cellular Component	GO:0043209	myelin sheath	Pkm	HDA		Mouse	MGI:MGI:3834050\|PMID:17634366
Cellular Component	GO:0005634	nucleus	PKM	IDA		Human	PMID:17308100
Cellular Component	GO:0005634	nucleus	PKM	IDA		Human	PMID:18191611
Cellular Component	GO:0005634	nucleus	PKM	HDA		Human	PMID:21630459
Cellular Component	GO:1902912	pyruvate kinase complex	Pkm	IDA		Rat	PMID:1883388\|RGD:12793012
Cellular Component	GO:0005791	rough endoplasmic reticulum	Pkm	IDA		Mouse	MGI:MGI:6331015\|PMID:28575669
Cellular Component	GO:0031982	vesicle	PKM	HDA		Human	PMID:19190083
Biological Process	GO:0031100	animal organ regeneration	Pkm	IDA		Rat	PMID:4005043\|RGD:2303141
Biological Process	GO:0006754	ATP biosynthetic process	Pkm	IDA		Rat	PMID:4273555\|RGD:2302790
Biological Process	GO:0061621	canonical glycolysis	Pkm	IDA		Mouse	PMID:28630053
Biological Process	GO:0006006	glucose metabolic process	Pkm	IDA		Rat	PMID:7929251\|RGD:2303136
Biological Process	GO:0006096	glycolytic process	Pkm	IDA		Mouse	PMID:7262549
Biological Process	GO:0006096	glycolytic process	Pkm	IDA		Mouse	PMID:7295297
Biological Process	GO:0006096	glycolytic process	Pkm	IDA		Rat	PMID:1883388\|RGD:12793012
Biological Process	GO:0006096	glycolytic process	Pkm	IDA		Rat	PMID:4273555\|RGD:2302790
Biological Process	GO:0001889	liver development	Pkm	IDA		Rat	PMID:7327170\|RGD:2303137
Biological Process	GO:2000767	positive regulation of cytoplasmic translation	Pkm	IDA		Mouse	MGI:MGI:6331015\|PMID:28575669
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	PKM	IMP		Human	PMID:27199445
Biological Process	GO:0012501	programmed cell death	PKM	IDA		Human	PMID:17308100
Biological Process	GO:0051289	protein homotetramerization	Pkm	IDA		Rat	PMID:10734049\|RGD:151708737
Biological Process	GO:0051262	protein tetramerization	Pkm	IDA		Rat	PMID:11687968\|RGD:152176659
Biological Process	GO:0042866	pyruvate biosynthetic process	Pkm	IDA		Rat	PMID:4273555\|RGD:2302790
Biological Process	GO:0006090	pyruvate metabolic process	Pkm	IDA		Rat	PMID:10734049\|RGD:151708737
Biological Process	GO:0009629	response to gravity	Pkm	IEP		Rat	PMID:12165359\|RGD:2303135
Biological Process	GO:0001666	response to hypoxia	Pkm	IEP		Rat	PMID:3696161\|RGD:2303142
Biological Process	GO:0032868	response to insulin	Pkm	IEP		Rat	PMID:7929251\|RGD:2303136
Biological Process	GO:0014870	response to muscle inactivity	Pkm	IEP		Rat	PMID:6331066\|RGD:2303140
Biological Process	GO:0007584	response to nutrient	Pkm	IEP		Rat	PMID:7929251\|RGD:2303136
Biological Process	GO:0010033	response to organic substance	Pkm	IEP		Rat	PMID:6537126\|RGD:2303139
Biological Process	GO:0043403	skeletal muscle tissue regeneration	Pkm	IDA		Rat	PMID:145474\|RGD:2303143
Biological Process	GO:0002040	sprouting angiogenesis	pkma	IGI	ZFIN:ZDB-GENO-210226-4	Zfish	PMID:30301887
Biological Process	GO:0002040	sprouting angiogenesis	pkmb	IGI	ZFIN:ZDB-GENO-210226-4	Zfish	PMID:30301887

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.