Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PKN2
  • Mouse genes Pkn2
  • Rat genes Pkn2
  • Zfish genes pkn2a,pkn2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pkn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	PKN2	HDA		Human	PMID:25468996
Molecular Function	GO:0042826	histone deacetylase binding	PKN2	IDA		Human	PMID:20188095
Molecular Function	GO:0016301	kinase activity	PKN2	IDA		Human	PMID:15364941
Molecular Function	GO:0005515	protein binding	PKN2	IPI	UniProtKB:O43639	Human	PMID:10026169
Molecular Function	GO:0005515	protein binding	PKN2	IPI	UniProtKB:P16333	Human	PMID:10026169
Molecular Function	GO:0005515	protein binding	PKN2	IPI	UniProtKB:Q12923	Human	PMID:11356191
Molecular Function	GO:0005515	protein binding	PKN2	IPI	UniProtKB:O92972:PRO_0000278753	Human	PMID:15364941
Molecular Function	GO:0005515	protein binding	PKN2	IPI	UniProtKB:Q15118	Human	PMID:17110931
Molecular Function	GO:0005515	protein binding	PKN2	IPI	UniProtKB:P08134	Human	PMID:20974804
Molecular Function	GO:0005515	protein binding	PKN2	IPI	UniProtKB:P61586	Human	PMID:20974804
Molecular Function	GO:0005515	protein binding	PKN2	IPI	UniProtKB:P63000	Human	PMID:20974804
Molecular Function	GO:0005515	protein binding	PKN2	IPI	UniProtKB:Q15131	Human	PMID:27104747
Molecular Function	GO:0005515	protein binding	Pkn2	IPI	UniProtKB:P63001|UniProtKB:Q9QUI0	Mouse	MGI:MGI:4941685|PMID:20974804
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PKN2	IDA		Human	PMID:20188095
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Pkn2	IDA		Rat	PMID:8051089|RGD:633689
Molecular Function	GO:0003723	RNA binding	PKN2	HDA		Human	PMID:22658674
Molecular Function	GO:0070063	RNA polymerase binding	PKN2	IPI	UniProtKB:O92972:PRO_0000278753	Human	PMID:15364941
Cellular Component	GO:0043296	apical junction complex	PKN2	IDA		Human	PMID:20974804
Cellular Component	GO:0043296	apical junction complex	Pkn2	IDA		Mouse	MGI:MGI:4941685|PMID:20974804
Cellular Component	GO:0005813	centrosome	PKN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032154	cleavage furrow	PKN2	IDA		Human	PMID:17332740
Cellular Component	GO:0005737	cytoplasm	PKN2	IDA		Human	PMID:17332740
Cellular Component	GO:0005737	cytoplasm	Pkn2	IDA		Mouse	PMID:12783890
Cellular Component	GO:0005829	cytosol	PKN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045111	intermediate filament cytoskeleton	PKN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030027	lamellipodium	PKN2	IDA		Human	PMID:11356191
Cellular Component	GO:0030496	midbody	PKN2	IDA		Human	PMID:17332740
Cellular Component	GO:0016604	nuclear body	PKN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PKN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PKN2	IDA		Human	PMID:11356191
Cellular Component	GO:0005634	nucleus	Pkn2	IDA		Mouse	PMID:12783890
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PKN2	IDA		Human	PMID:15364941
Cellular Component	GO:0005886	plasma membrane	PKN2	IDA		Human	GO_REF:0000052
Biological Process	GO:0043297	apical junction assembly	PKN2	IMP		Human	PMID:20974804
Biological Process	GO:0043297	apical junction assembly	Pkn2	IDA		Mouse	MGI:MGI:4941685|PMID:20974804
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	pkn2a	IMP	ZFIN:ZDB-MRPHLNO-151112-3	Zfish	PMID:25533962
Biological Process	GO:0010631	epithelial cell migration	PKN2	IDA		Human	PMID:21754995
Biological Process	GO:0007507	heart development	pkn2a	IMP	ZFIN:ZDB-MRPHLNO-151112-3	Zfish	PMID:25533962
Biological Process	GO:0032467	positive regulation of cytokinesis	PKN2	IMP		Human	PMID:17332740
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	PKN2	IMP		Human	PMID:17332740
Biological Process	GO:0045070	positive regulation of viral genome replication	PKN2	IMP		Human	PMID:15364941
Biological Process	GO:0006468	protein phosphorylation	PKN2	IDA		Human	PMID:17332740
Biological Process	GO:2000145	regulation of cell motility	PKN2	IMP		Human	PMID:21754995

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern