Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PKP2
  • Mouse genes Pkp2
  • Rat genes Pkp2
  • Zfish genes pkp2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pkp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045294	alpha-catenin binding	PKP2	IPI	UniProtKB:Q9UI47	Human	PMID:23136403
Molecular Function	GO:0045296	cadherin binding	PKP2	HDA		Human	PMID:25468996
Molecular Function	GO:0019215	intermediate filament binding	PKP2	IDA		Human	PMID:10852826
Molecular Function	GO:0060090	molecular adaptor activity	PKP2	IMP		Human	PMID:18474624
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P05783	Human	PMID:10852826
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P05787	Human	PMID:10852826
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P08670	Human	PMID:10852826
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P13647	Human	PMID:10852826
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P19012	Human	PMID:10852826
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:O14802	Human	PMID:11416169
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:Q9BUI4	Human	PMID:11416169
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:Q9H1D9	Human	PMID:11416169
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P12830	Human	PMID:11790773
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P14923	Human	PMID:11790773
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P15924	Human	PMID:11790773
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P32926	Human	PMID:11790773
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P35222	Human	PMID:11790773
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:Q02413	Human	PMID:11790773
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:Q14126	Human	PMID:11790773
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P27448	Human	PMID:12941695
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:Q5JR59	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:Q9GZM8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:C5E526	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:P03431	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:Q1K9H5	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:Q5EP37	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	PKP2	IPI	UniProtKB:Q5JR59	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Pkp2	IPI	PR:Q02248	Mouse	PMID:17535849
Molecular Function	GO:0005515	protein binding	Pkp2	IPI	UniProtKB:Q02487	Rat	PMID:21062920|RGD:8553494
Molecular Function	GO:0005515	protein binding	Pkp2	IPI	UniProtKB:Q02487-1	Rat	PMID:21220045|RGD:15014787
Molecular Function	GO:0005515	protein binding	Pkp2	IPI	RGD:1591792	Rat	PMID:22670221|RGD:6784500
Molecular Function	GO:0005515	protein binding	Pkp2	IPI	RGD:69247	Rat	PMID:23066018|RGD:7296922
Molecular Function	GO:0005080	protein kinase C binding	PKP2	IPI	UniProtKB:P04409	Human	PMID:18474624
Cellular Component	GO:0005912	adherens junction	Pkp2	IDA		Rat	PMID:16406610|RGD:1581654
Cellular Component	GO:0030054	cell junction	PKP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030054	cell junction	Pkp2	IDA		Rat	PMID:26858265|RGD:11526329
Cellular Component	GO:0005911	cell-cell junction	PKP2	IDA		Human	PMID:23884246
Cellular Component	GO:0005911	cell-cell junction	Pkp2	IDA		Mouse	PMID:21296051
Cellular Component	GO:0005911	cell-cell junction	Pkp2	IMP	MGI:MGI:3487374	Mouse	PMID:15479741
Cellular Component	GO:0005737	cytoplasm	PKP2	IDA		Human	PMID:34368962
Cellular Component	GO:0030057	desmosome	PKP2	IDA		Human	PMID:34368962
Cellular Component	GO:0030057	desmosome	Pkp2	IDA		Mouse	PMID:22274697
Cellular Component	GO:0030057	desmosome	Pkp2	IDA		Mouse	PMID:9864371
Cellular Component	GO:0014704	intercalated disc	PKP2	IDA		Human	PMID:22781308
Cellular Component	GO:0014704	intercalated disc	Pkp2	IDA		Mouse	PMID:17535849
Cellular Component	GO:0014704	intercalated disc	Pkp2	IDA		Rat	PMID:19661460|RGD:6784504
Cellular Component	GO:0005882	intermediate filament	Pkp2	IDA		Mouse	MGI:MGI:3723417|PMID:16917092
Cellular Component	GO:0005654	nucleoplasm	PKP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PKP2	IDA		Human	PMID:11416169
Cellular Component	GO:0005634	nucleus	PKP2	IDA		Human	PMID:11790773
Cellular Component	GO:0005634	nucleus	PKP2	IDA		Human	PMID:34368962
Cellular Component	GO:0005886	plasma membrane	PKP2	IDA		Human	PMID:20859650
Cellular Component	GO:0005886	plasma membrane	PKP2	IDA		Human	PMID:23863954
Biological Process	GO:0034334	adherens junction maintenance	Pkp2	IMP		Rat	PMID:18261826|RGD:6784508
Biological Process	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	PKP2	IMP		Human	PMID:22889254
Biological Process	GO:0086001	cardiac muscle cell action potential	Pkp2	IMP		Rat	PMID:19661460|RGD:6784504
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	PKP2	IMP		Human	PMID:22889254
Biological Process	GO:0098609	cell-cell adhesion	Pkp2	IMP	MGI:MGI:3487374	Mouse	PMID:15479741
Biological Process	GO:0086019	cell-cell signaling involved in cardiac conduction	PKP2	IMP		Human	PMID:22889254
Biological Process	GO:0002159	desmosome assembly	PKP2	IMP		Human	PMID:18474624
Biological Process	GO:0002934	desmosome organization	pkp2	IMP	ZFIN:ZDB-MRPHLNO-130304-7	Zfish	PMID:23124967
Biological Process	GO:0016264	gap junction assembly	Pkp2	IMP		Rat	PMID:17673670|RGD:6784510
Biological Process	GO:0007507	heart development	Pkp2	IMP	MGI:MGI:3487374	Mouse	PMID:15479741
Biological Process	GO:0007507	heart development	pkp2	IMP	ZFIN:ZDB-MRPHLNO-130304-7	Zfish	PMID:23124967
Biological Process	GO:0001947	heart looping	pkp2	IMP	ZFIN:ZDB-MRPHLNO-130304-7	Zfish	PMID:23124967
Biological Process	GO:0045110	intermediate filament bundle assembly	PKP2	IMP		Human	PMID:18474624
Biological Process	GO:0055088	lipid homeostasis	Pkp2	IMP		Rat	PMID:21985446|RGD:6892694
Biological Process	GO:0048496	maintenance of animal organ identity	PKP2	IMP		Human	PMID:22889254
Biological Process	GO:0030336	negative regulation of cell migration	Pkp2	IMP		Rat	PMID:21985446|RGD:6892694
Biological Process	GO:0008285	negative regulation of cell population proliferation	Pkp2	IMP		Rat	PMID:21985446|RGD:6892694
Biological Process	GO:0072659	protein localization to plasma membrane	PKP2	IMP		Human	PMID:23863954
Biological Process	GO:2000810	regulation of bicellular tight junction assembly	Pkp2	IMP		Rat	PMID:19509333|RGD:6784505
Biological Process	GO:0010810	regulation of cell-substrate adhesion	PKP2	IMP		Human	PMID:23884246
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	PKP2	IMP		Human	PMID:17980246
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	PKP2	IMP		Human	PMID:22889254
Biological Process	GO:1900024	regulation of substrate adhesion-dependent cell spreading	PKP2	IMP		Human	PMID:23884246
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	PKP2	IMP		Human	PMID:22889254
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	PKP2	IMP		Human	PMID:22889254
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	PKP2	IMP		Human	PMID:22889254

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern