Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLA2G3
  • Mouse genes Pla2g3
  • Rat genes Pla2g3
  • Zfish genes pla2g3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pla2g3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	PLA2G3	IDA		Human	PMID:12522102
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	PLA2G3	IDA		Human	PMID:18801741
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	PLA2G3	IDA		Human	PMID:28947740
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	Pla2g3	IMP		Mouse	MGI:MGI:5492190|PMID:23624557
Molecular Function	GO:0004620	phospholipase activity	Pla2g3	IDA		Mouse	PMID:28947740
Cellular Component	GO:0005814	centriole	PLA2G3	IDA		Human	PMID:20393563
Cellular Component	GO:0055037	recycling endosome	PLA2G3	IDA		Human	PMID:20393563
Biological Process	GO:0001675	acrosome assembly	Pla2g3	IMP	MGI:MGI:4461174	Mouse	PMID:20424323
Biological Process	GO:0048468	cell development	Pla2g3	IMP	MGI:MGI:4461174	Mouse	PMID:23624557
Biological Process	GO:0048469	cell maturation	Pla2g3	IMP	MGI:MGI:4461174	Mouse	PMID:28947740
Biological Process	GO:0060271	cilium assembly	PLA2G3	IMP		Human	PMID:20393563
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	PLA2G3	IDA		Human	PMID:18801741
Biological Process	GO:0019372	lipoxygenase pathway	Pla2g3	IMP	MGI:MGI:4461174	Mouse	PMID:20424323
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	PLA2G3	IDA		Human	PMID:18801741
Biological Process	GO:0042116	macrophage activation	Pla2g3	IDA		Mouse	PMID:28947740
Biological Process	GO:0043303	mast cell degranulation	Pla2g3	IMP	MGI:MGI:4461174	Mouse	PMID:23624557
Biological Process	GO:1900222	negative regulation of amyloid-beta clearance	Pla2g3	IDA		Mouse	PMID:26637123
Biological Process	GO:0010629	negative regulation of gene expression	PLA2G3	IDA		Human	PMID:26637123
Biological Process	GO:0010629	negative regulation of gene expression	Pla2g3	IDA		Mouse	PMID:26637123
Biological Process	GO:0010629	negative regulation of gene expression	Pla2g3	IDA		Rat	PMID:26637123|RGD:11342276
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	PLA2G3	IMP		Human	PMID:17868035
Biological Process	GO:0046473	phosphatidic acid metabolic process	PLA2G3	IDA		Human	PMID:28947740
Biological Process	GO:0046470	phosphatidylcholine metabolic process	PLA2G3	IDA		Human	PMID:28947740
Biological Process	GO:0046470	phosphatidylcholine metabolic process	Pla2g3	IMP	MGI:MGI:4461174	Mouse	PMID:20424323
Biological Process	GO:0046337	phosphatidylethanolamine metabolic process	PLA2G3	IDA		Human	PMID:28947740
Biological Process	GO:0046471	phosphatidylglycerol metabolic process	PLA2G3	IDA		Human	PMID:28947740
Biological Process	GO:0046488	phosphatidylinositol metabolic process	PLA2G3	IDA		Human	PMID:28947740
Biological Process	GO:0006658	phosphatidylserine metabolic process	PLA2G3	IDA		Human	PMID:28947740
Biological Process	GO:0006644	phospholipid metabolic process	Pla2g3	IDA		Mouse	PMID:28947740
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Pla2g3	IMP	MGI:MGI:4461174	Mouse	PMID:28947740
Biological Process	GO:1903595	positive regulation of histamine secretion by mast cell	PLA2G3	IDA		Human	PMID:23624557
Biological Process	GO:1903595	positive regulation of histamine secretion by mast cell	Pla2g3	IMP		Mouse	MGI:MGI:5492190|PMID:23624557
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	PLA2G3	IDA		Human	PMID:18801741
Biological Process	GO:0060376	positive regulation of mast cell differentiation	Pla2g3	IMP		Mouse	MGI:MGI:5492190|PMID:23624557
Biological Process	GO:0010976	positive regulation of neuron projection development	PLA2G3	IMP		Human	PMID:17868035
Biological Process	GO:0010976	positive regulation of neuron projection development	Pla2g3	IMP		Mouse	MGI:MGI:6436441|PMID:17868035
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	PLA2G3	IDA		Human	PMID:23624557
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	Pla2g3	IMP		Mouse	MGI:MGI:5492190|PMID:23624557
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	Pla2g3	IMP	MGI:MGI:4461174	Mouse	PMID:28947740
Biological Process	GO:0002532	production of molecular mediator involved in inflammatory response	Pla2g3	IMP	MGI:MGI:4461174	Mouse	PMID:28947740
Biological Process	GO:2001135	regulation of endocytic recycling	PLA2G3	IMP		Human	PMID:20393563
Biological Process	GO:0007288	sperm axoneme assembly	Pla2g3	IMP	MGI:MGI:4461174	Mouse	PMID:20424323

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern