Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLA2G4A
  • Mouse genes Pla2g4a
  • Rat genes Pla2g4a
  • Zfish genes pla2g4aa,pla2g4ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pla2g4a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	PLA2G4A	IDA		Human	PMID:9430701
Molecular Function	GO:0005509	calcium ion binding	PLA2G4A	IDA		Human	PMID:9665851
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	PLA2G4A	IDA		Human	PMID:14709560
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	PLA2G4A	IDA		Human	PMID:16617059
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	PLA2G4A	IDA		Human	PMID:17472963
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	PLA2G4A	IMP		Human	PMID:18451993
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	PLA2G4A	IDA		Human	PMID:7794891
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	PLA2G4A	IDA		Human	PMID:9425121
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	Pla2g4a	IMP		Mouse	MGI:MGI:1100763|PMID:9403693
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	Pla2g4a	IDA		Rat	PMID:8148815|RGD:1642483
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	PLA2G4A	IDA		Human	PMID:9665851
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	PLA2G4A	IDA		Human	PMID:12672805
Molecular Function	GO:1902387	ceramide 1-phosphate binding	PLA2G4A	IDA		Human	PMID:17472963
Molecular Function	GO:0035035	histone acetyltransferase binding	Pla2g4a	IPI	RGD:621061	Rat	PMID:11416127|RGD:9588319
Molecular Function	GO:0004622	lysophospholipase activity	PLA2G4A	IDA		Human	PMID:12672805
Molecular Function	GO:0004622	lysophospholipase activity	PLA2G4A	IDA		Human	PMID:16617059
Molecular Function	GO:0004622	lysophospholipase activity	PLA2G4A	IDA		Human	PMID:27642067
Molecular Function	GO:0008374	O-acyltransferase activity	PLA2G4A	IDA		Human	PMID:7794891
Molecular Function	GO:0032266	phosphatidylinositol-3-phosphate binding	PLA2G4A	IDA		Human	PMID:12672805
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	PLA2G4A	IDA		Human	PMID:12672805
Molecular Function	GO:0010314	phosphatidylinositol-5-phosphate binding	PLA2G4A	IDA		Human	PMID:12672805
Molecular Function	GO:0004623	phospholipase A2 activity	PLA2G4A	IDA		Human	PMID:8702602
Molecular Function	GO:0004623	phospholipase A2 activity	Pla2g4a	IDA		Mouse	MGI:MGI:5297793|PMID:10946309
Molecular Function	GO:0004620	phospholipase activity	pla2g4ab	IDA		Zfish	PMID:26644349
Molecular Function	GO:0004620	phospholipase activity	pla2g4aa	IDA		Zfish	PMID:26644349
Cellular Component	GO:0005737	cytoplasm	PLA2G4A	IDA		Human	PMID:11375391
Cellular Component	GO:0005737	cytoplasm	Pla2g4a	IDA		Rat	PMID:15486059|RGD:1642463
Cellular Component	GO:0005829	cytosol	PLA2G4A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Pla2g4a	IDA		Mouse	MGI:MGI:5297793|PMID:10946309
Cellular Component	GO:0005829	cytosol	Pla2g4a	IDA		Mouse	PMID:17293613
Cellular Component	GO:0005829	cytosol	Pla2g4a	IDA		Rat	PMID:12490538|RGD:1642471
Cellular Component	GO:0005783	endoplasmic reticulum	Pla2g4a	IDA		Mouse	PMID:17293613
Cellular Component	GO:0005794	Golgi apparatus	Pla2g4a	IDA		Mouse	PMID:17293613
Cellular Component	GO:0000139	Golgi membrane	PLA2G4A	IDA		Human	PMID:11375391
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PLA2G4A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Pla2g4a	IDA		Rat	PMID:1642464|RGD:6893514
Cellular Component	GO:0005635	nuclear envelope	PLA2G4A	IDA		Human	PMID:11375391
Cellular Component	GO:0005634	nucleus	Pla2g4a	IDA		Rat	PMID:15368358|RGD:1642464
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Pla2g4a	IDA		Rat	PMID:15486059|RGD:1642463
Cellular Component	GO:0042588	zymogen granule	Pla2g4a	IDA		Rat	PMID:17148545|RGD:1642447
Biological Process	GO:0007568	aging	Pla2g4a	IEP		Rat	PMID:15368358|RGD:1642464
Biological Process	GO:0019369	arachidonic acid metabolic process	PLA2G4A	IDA		Human	PMID:7794891
Biological Process	GO:0019369	arachidonic acid metabolic process	Pla2g4a	IMP		Rat	PMID:16603549|RGD:1642459
Biological Process	GO:0050482	arachidonic acid secretion	Pla2g4a	IDA		Mouse	MGI:MGI:5297793|PMID:10946309
Biological Process	GO:0050482	arachidonic acid secretion	Pla2g4a	IMP		Mouse	PMID:17293613
Biological Process	GO:0071236	cellular response to antibiotic	Pla2g4a	IDA		Mouse	PMID:17293613
Biological Process	GO:0046697	decidualization	Pla2g4a	IMP		Rat	PMID:10050766|RGD:1642479
Biological Process	GO:0051649	establishment of localization in cell	Pla2g4a	IMP		Mouse	PMID:17293613
Biological Process	GO:0046456	icosanoid biosynthetic process	Pla2g4a	IMP		Mouse	PMID:17293613
Biological Process	GO:0090594	inflammatory response to wounding	pla2g4aa	IMP	ZFIN:ZDB-GENO-161011-1	Zfish	PMID:27203112
Biological Process	GO:0019370	leukotriene biosynthetic process	PLA2G4A	IMP		Human	PMID:18451993
Biological Process	GO:0019370	leukotriene biosynthetic process	Pla2g4a	IMP		Mouse	MGI:MGI:1100763|PMID:9403693
Biological Process	GO:0001554	luteolysis	Pla2g4a	IEP		Rat	PMID:11444430|RGD:1642472
Biological Process	GO:0006640	monoacylglycerol biosynthetic process	PLA2G4A	IDA		Human	PMID:7794891
Biological Process	GO:0001541	ovarian follicle development	pla2g4aa	IEP		Zfish	PMID:19551897
Biological Process	GO:0001542	ovulation from ovarian follicle	Pla2g4a	IMP		Rat	PMID:10189070|RGD:1642477
Biological Process	GO:0036151	phosphatidylcholine acyl-chain remodeling	PLA2G4A	IDA		Human	PMID:16617059
Biological Process	GO:0034638	phosphatidylcholine catabolic process	PLA2G4A	IDA		Human	PMID:12672805
Biological Process	GO:0034638	phosphatidylcholine catabolic process	PLA2G4A	IDA		Human	PMID:14709560
Biological Process	GO:0034638	phosphatidylcholine catabolic process	PLA2G4A	IDA		Human	PMID:17472963
Biological Process	GO:0034638	phosphatidylcholine catabolic process	PLA2G4A	IDA		Human	PMID:7794891
Biological Process	GO:0034638	phosphatidylcholine catabolic process	PLA2G4A	IDA		Human	PMID:9425121
Biological Process	GO:0034638	phosphatidylcholine catabolic process	Pla2g4a	IMP		Mouse	MGI:MGI:1100763|PMID:9403693
Biological Process	GO:0034478	phosphatidylglycerol catabolic process	PLA2G4A	IDA		Human	PMID:9425121
Biological Process	GO:0006663	platelet activating factor biosynthetic process	Pla2g4a	IMP		Mouse	MGI:MGI:1100762|PMID:9403692
Biological Process	GO:0043065	positive regulation of apoptotic process	Pla2g4a	IMP		Rat	PMID:15486059|RGD:1642463
Biological Process	GO:0030501	positive regulation of bone mineralization	Pla2g4a	IEP		Rat	PMID:10807497|RGD:1642474
Biological Process	GO:0008284	positive regulation of cell population proliferation	Pla2g4a	IMP		Rat	PMID:17060404|RGD:1642450
Biological Process	GO:0031622	positive regulation of fever generation	Pla2g4a	IEP		Rat	PMID:16933973|RGD:1642453
Biological Process	GO:0050729	positive regulation of inflammatory response	Pla2g4a	IMP		Rat	PMID:17305324|RGD:1642446
Biological Process	GO:0043032	positive regulation of macrophage activation	Pla2g4a	IMP		Mouse	MGI:MGI:1100763|PMID:9403693
Biological Process	GO:0043032	positive regulation of macrophage activation	Pla2g4a	IMP		Mouse	MGI:MGI:1100762|PMID:9403692
Biological Process	GO:0010572	positive regulation of platelet activation	PLA2G4A	IMP		Human	PMID:18451993
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	Pla2g4a	IMP		Rat	PMID:16203828|RGD:1642461
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	Pla2g4a	IMP	MGI:MGI:2385582	Mouse	PMID:26828067
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	Pla2g4a	IMP		Mouse	MGI:MGI:3621220|PMID:16172261
Biological Process	GO:0031340	positive regulation of vesicle fusion	Pla2g4a	IMP		Rat	PMID:17148545|RGD:1642447
Biological Process	GO:0001516	prostaglandin biosynthetic process	PLA2G4A	IMP		Human	PMID:18451993
Biological Process	GO:0001516	prostaglandin biosynthetic process	PLA2G4A	IDA		Human	PMID:27642067
Biological Process	GO:0001516	prostaglandin biosynthetic process	Pla2g4a	IMP		Mouse	MGI:MGI:1100762|PMID:9403692
Biological Process	GO:0001516	prostaglandin biosynthetic process	Pla2g4a	IMP		Mouse	MGI:MGI:1100763|PMID:9403693
Biological Process	GO:0042127	regulation of cell population proliferation	Pla2g4a	IGI	MGI:MGI:88039	Mouse	PMID:10969066
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	pla2g4ab	IGI	ZFIN:ZDB-MRPHLNO-160426-1,ZFIN:ZDB-MRPHLNO-160426-2	Zfish	PMID:26644349
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	pla2g4aa	IGI	ZFIN:ZDB-MRPHLNO-160426-1,ZFIN:ZDB-MRPHLNO-160426-2	Zfish	PMID:26644349
Biological Process	GO:0051592	response to calcium ion	Pla2g4a	IMP		Rat	PMID:16828086|RGD:1642455
Biological Process	GO:0051384	response to glucocorticoid	Pla2g4a	IEP		Rat	PMID:10092307|RGD:1642478
Biological Process	GO:0009408	response to heat	Pla2g4a	IEP		Rat	PMID:17483741|RGD:1642444
Biological Process	GO:0009725	response to hormone	Pla2g4a	IEP		Rat	PMID:15368358|RGD:1642464
Biological Process	GO:0042542	response to hydrogen peroxide	Pla2g4a	IEP		Rat	PMID:16864412|RGD:1642454
Biological Process	GO:0032496	response to lipopolysaccharide	Pla2g4a	IEP		Rat	PMID:17093905|RGD:1642448
Biological Process	GO:0010226	response to lithium ion	Pla2g4a	IEP		Rat	PMID:10716228|RGD:8694084
Biological Process	GO:0051597	response to methylmercury	Pla2g4a	IEP		Rat	PMID:15019302|RGD:1642468
Biological Process	GO:0010033	response to organic substance	Pla2g4a	IMP		Rat	PMID:17093080|RGD:1642449
Biological Process	GO:0010243	response to organonitrogen compound	Pla2g4a	IEP		Rat	PMID:16603213|RGD:1642460
Biological Process	GO:0033280	response to vitamin D	Pla2g4a	IEP		Rat	PMID:15225789|RGD:1642467
Biological Process	GO:0009611	response to wounding	pla2g4aa	IMP	ZFIN:ZDB-MRPHLNO-131028-4	Zfish	PMID:23934216
Biological Process	GO:0043129	surfactant homeostasis	Pla2g4a	IMP		Rat	PMID:10025671|RGD:1642480

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern