Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLA2G5
  • Mouse genes Pla2g5
  • Rat genes Pla2g5
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pla2g5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	Pla2g5	IDA		Rat	PMID:7947992|RGD:61698
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	PLA2G5	IDA		Human	PMID:23533611
Molecular Function	GO:0008201	heparin binding	Pla2g5	IDA		Rat	PMID:9603953|RGD:2303038
Molecular Function	GO:0004623	phospholipase A2 activity	Pla2g5	IDA		Mouse	MGI:MGI:5297792|PMID:11830583
Molecular Function	GO:0005102	signaling receptor binding	Pla2g5	IPI	UniProtKB:Q62028:PRO_0000311251	Mouse	MGI:MGI:5297792|PMID:11830583
Cellular Component	GO:0009986	cell surface	Pla2g5	IDA		Mouse	PMID:8943302
Cellular Component	GO:0032009	early phagosome	Pla2g5	IDA		Mouse	MGI:MGI:3639848|PMID:16407308
Cellular Component	GO:0005794	Golgi apparatus	Pla2g5	IDA		Rat	PMID:11341961|RGD:2303036
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Pla2g5	IDA		Rat	PMID:11341961|RGD:2303036
Cellular Component	GO:0032010	phagolysosome	Pla2g5	IDA		Mouse	MGI:MGI:3639848|PMID:16407308
Cellular Component	GO:0005886	plasma membrane	Pla2g5	IDA		Rat	PMID:11106649|RGD:2303037
Biological Process	GO:0050482	arachidonic acid secretion	Pla2g5	IDA		Mouse	MGI:MGI:5297792|PMID:11830583
Biological Process	GO:0050482	arachidonic acid secretion	Pla2g5	IDA		Rat	PMID:11106649|RGD:2303037
Biological Process	GO:0035965	cardiolipin acyl-chain remodeling	PLA2G5	IDA		Human	PMID:23533611
Biological Process	GO:0019370	leukotriene biosynthetic process	PLA2G5	IDA		Human	PMID:20432503
Biological Process	GO:0019370	leukotriene biosynthetic process	Pla2g5	IDA		Rat	PMID:11106649|RGD:2303037
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	Pla2g5	IDA		Mouse	MGI:MGI:6393145|PMID:14962950
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	Pla2g5	IMP	MGI:MGI:3042209	Mouse	PMID:24910243
Biological Process	GO:0050728	negative regulation of inflammatory response	Pla2g5	IMP	MGI:MGI:3042209	Mouse	PMID:24910243
Biological Process	GO:0090385	phagosome-lysosome fusion	Pla2g5	IMP		Mouse	MGI:MGI:3841317|PMID:19342668
Biological Process	GO:0034638	phosphatidylcholine catabolic process	PLA2G5	IDA		Human	PMID:23533611
Biological Process	GO:0006644	phospholipid metabolic process	Pla2g5	IDA		Mouse	MGI:MGI:5297792|PMID:11830583
Biological Process	GO:0006663	platelet activating factor biosynthetic process	Pla2g5	IDA		Rat	PMID:11106649|RGD:2303037
Biological Process	GO:1905036	positive regulation of antifungal innate immune response	Pla2g5	IMP		Mouse	MGI:MGI:3841317|PMID:19342668
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PLA2G5	IDA		Human	PMID:22837859
Biological Process	GO:0090265	positive regulation of immune complex clearance by monocytes and macrophages	PLA2G5	IDA		Human	PMID:20432503
Biological Process	GO:0090265	positive regulation of immune complex clearance by monocytes and macrophages	Pla2g5	IMP		Mouse	MGI:MGI:5810005|PMID:20432503
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	Pla2g5	IDA		Mouse	MGI:MGI:6393145|PMID:14962950
Biological Process	GO:1903028	positive regulation of opsonization	Pla2g5	IMP		Mouse	MGI:MGI:3841317|PMID:19342668
Biological Process	GO:0050766	positive regulation of phagocytosis	Pla2g5	IMP		Mouse	MGI:MGI:3639848|PMID:16407308
Biological Process	GO:1905164	positive regulation of phagosome maturation	Pla2g5	IMP		Mouse	MGI:MGI:3841317|PMID:19342668
Biological Process	GO:0010518	positive regulation of phospholipase activity	PLA2G5	IDA		Human	PMID:22837859
Biological Process	GO:0043030	regulation of macrophage activation	Pla2g5	IMP	MGI:MGI:3042209	Mouse	PMID:24910243
Biological Process	GO:0051591	response to cAMP	Pla2g5	IEP		Rat	PMID:11341961|RGD:2303036
Biological Process	GO:0034097	response to cytokine	Pla2g5	IEP		Rat	PMID:11341961|RGD:2303036

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern