Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLA2G6
  • Mouse genes Pla2g6
  • Rat genes Pla2g6
  • Zfish genes pla2g6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pla2g6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043008	ATP-dependent protein binding	Pla2g6	IDA		Rat	PMID:20732873|RGD:6482749
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	PLA2G6	IDA		Human	PMID:15908428
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	PLA2G6	IDA		Human	PMID:20886109
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	PLA2G6	IDA		Human	PMID:23533611
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	Pla2g6	IMP		Mouse	MGI:MGI:3831205|PMID:18937505
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	Pla2g6	IMP		Mouse	MGI:MGI:3778607|PMID:17895289
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	Pla2g6	IDA		Rat	PMID:18937505|RGD:25671384
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	Pla2g6	IDA		Rat	PMID:24648512|RGD:25671395
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	Pla2g6	IDA		Rat	PMID:9111008|RGD:729507
Molecular Function	GO:0042802	identical protein binding	PLA2G6	IPI	UniProtKB:O60733	Human	PMID:32296183
Molecular Function	GO:0004622	lysophospholipase activity	PLA2G6	IDA		Human	PMID:20886109
Molecular Function	GO:0016290	palmitoyl-CoA hydrolase activity	PLA2G6	IDA		Human	PMID:20886109
Molecular Function	GO:0016290	palmitoyl-CoA hydrolase activity	Pla2g6	IMP		Mouse	MGI:MGI:3831205|PMID:18937505
Molecular Function	GO:0016290	palmitoyl-CoA hydrolase activity	Pla2g6	IDA		Rat	PMID:18937505|RGD:25671384
Molecular Function	GO:0005515	protein binding	PLA2G6	IPI	UniProtKB:B2RXF5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLA2G6	IPI	UniProtKB:O95199	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLA2G6	IPI	UniProtKB:Q14140	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLA2G6	IPI	UniProtKB:Q70EL1-9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLA2G6	IPI	UniProtKB:Q86XT4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLA2G6	IPI	UniProtKB:Q8N1F7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLA2G6	IPI	UniProtKB:Q8TAP6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLA2G6	IPI	UniProtKB:Q9BVN2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLA2G6	IPI	UniProtKB:Q9NZL9	Human	PMID:32296183
Molecular Function	GO:0019901	protein kinase binding	Pla2g6	IPI	RGD:2262	Rat	PMID:15576376|RGD:6482753
Molecular Function	GO:0017171	serine hydrolase activity	Pla2g6	IDA		Mouse	PMID:16818490
Cellular Component	GO:0034451	centriolar satellite	PLA2G6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	PLA2G6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Pla2g6	IDA		Rat	PMID:9111008|RGD:729507
Cellular Component	GO:0005615	extracellular space	PLA2G6	IDA		Human	PMID:18714013
Cellular Component	GO:0005739	mitochondrion	Pla2g6	IDA		Rat	PMID:18936091|RGD:6482750
Biological Process	GO:0019731	antibacterial humoral response	PLA2G6	IDA		Human	PMID:18714013
Biological Process	GO:0035965	cardiolipin acyl-chain remodeling	PLA2G6	IDA		Human	PMID:23533611
Biological Process	GO:0035965	cardiolipin acyl-chain remodeling	Pla2g6	IDA		Rat	PMID:24648512|RGD:25671395
Biological Process	GO:0032049	cardiolipin biosynthetic process	PLA2G6	IMP		Human	PMID:19164547
Biological Process	GO:0060135	maternal process involved in female pregnancy	Pla2g6	IEP		Rat	PMID:16436530|RGD:6482751
Biological Process	GO:0007613	memory	Pla2g6	IMP		Rat	PMID:15830227|RGD:6482752
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	Pla2g6	IMP		Rat	PMID:15132431|RGD:6482754
Biological Process	GO:0034638	phosphatidylcholine catabolic process	PLA2G6	IDA		Human	PMID:20886109
Biological Process	GO:0090238	positive regulation of arachidonic acid secretion	Pla2g6	IDA		Rat	PMID:15576376|RGD:6482753
Biological Process	GO:0090238	positive regulation of arachidonic acid secretion	Pla2g6	IMP		Rat	PMID:20732873|RGD:6482749
Biological Process	GO:2000304	positive regulation of ceramide biosynthetic process	Pla2g6	IDA		Rat	PMID:18936091|RGD:6482750
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Pla2g6	IMP		Rat	PMID:21178110|RGD:6482747
Biological Process	GO:0045921	positive regulation of exocytosis	Pla2g6	IMP		Rat	PMID:12023524|RGD:6482759
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Pla2g6	IMP		Mouse	MGI:MGI:3778607|PMID:17895289
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Pla2g6	IDA		Rat	PMID:11278673|RGD:6482760
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	Pla2g6	IMP		Rat	PMID:22057271|RGD:6482746
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Pla2g6	IDA		Rat	PMID:15576376|RGD:6482753
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	Pla2g6	IDA		Rat	PMID:18936091|RGD:6482750
Biological Process	GO:1901339	regulation of store-operated calcium channel activity	Pla2g6	IMP		Rat	PMID:12547829|RGD:6482757
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Pla2g6	IDA		Rat	PMID:20732873|RGD:6482749
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	Pla2g6	IMP		Rat	PMID:12750876|RGD:6482755
Biological Process	GO:0042311	vasodilation	Pla2g6	IMP		Rat	PMID:12183647|RGD:6482758

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern