Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLAU
  • Mouse genes Plau
  • Rat genes Plau
  • Zfish genes plaua,plaub
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plau

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008233	peptidase activity	Plau	IDA		Rat	PMID:2509088|RGD:6484220
Molecular Function	GO:0005515	protein binding	PLAU	IPI	UniProtKB:P05154	Human	PMID:10340997
Molecular Function	GO:0005515	protein binding	PLAU	IPI	UniProtKB:P05154	Human	PMID:14696115
Molecular Function	GO:0005515	protein binding	PLAU	IPI	UniProtKB:Q03405-1	Human	PMID:18376415
Molecular Function	GO:0005515	protein binding	PLAU	IPI	UniProtKB:Q9UKQ2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLAU	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PLAU	IPI	UniProtKB:P05154	Human	PMID:3501295
Molecular Function	GO:0005515	protein binding	PLAU	IPI	UniProtKB:Q9UBG0	Human	PMID:7904248
Molecular Function	GO:0005515	protein binding	Plau	IPI	PR:Q9Z0K7	Mouse	PMID:25168896
Cellular Component	GO:0009986	cell surface	PLAU	IDA		Human	PMID:18835034
Cellular Component	GO:0070062	extracellular exosome	PLAU	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	PLAU	IDA		Human	PMID:18835034
Cellular Component	GO:0005615	extracellular space	PLAU	IDA		Human	PMID:24434139
Cellular Component	GO:0005615	extracellular space	Plau	IDA		Rat	PMID:10727258|RGD:6484219
Cellular Component	GO:0005925	focal adhesion	PLAU	HDA		Human	PMID:21423176
Cellular Component	GO:0016020	membrane	Plau	IDA		Rat	PMID:17939964|RGD:6484142
Cellular Component	GO:0098637	protein complex involved in cell-matrix adhesion	PLAU	IPI		Human	PMID:24465541
Cellular Component	GO:0097180	serine protease inhibitor complex	PLAU	IPI		Human	PMID:21199867
Cellular Component	GO:1905370	serine-type endopeptidase complex	PLAU	IPI		Human	PMID:22285761
Cellular Component	GO:1905370	serine-type endopeptidase complex	Plau	IPI		Mouse	MGI:MGI:4838953|PMID:20133942
Biological Process	GO:0001525	angiogenesis	Plau	IMP		Rat	PMID:15854129|RGD:1581926
Biological Process	GO:0071498	cellular response to fluid shear stress	Plau	IEP		Rat	PMID:19166201|RGD:7241210
Biological Process	GO:0071333	cellular response to glucose stimulus	Plau	IEP		Rat	PMID:17953365|RGD:7241217
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	Plau	IEP		Rat	PMID:19834131|RGD:7241796
Biological Process	GO:0071456	cellular response to hypoxia	Plau	IEP		Rat	PMID:19490965|RGD:7241802
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Plau	IEP		Rat	PMID:19184369|RGD:7241806
Biological Process	GO:0071310	cellular response to organic substance	Plau	IEP		Rat	PMID:20731662|RGD:7241586
Biological Process	GO:0072734	cellular response to staurosporine	Plau	IEP		Rat	PMID:19137075|RGD:7241807
Biological Process	GO:0007566	embryo implantation	Plau	IEP		Rat	PMID:15019809|RGD:1581927
Biological Process	GO:0042730	fibrinolysis	Plau	IMP		Mouse	PMID:9733098
Biological Process	GO:0031639	plasminogen activation	PLAU	IDA		Human	PMID:25978044
Biological Process	GO:0031639	plasminogen activation	plaub	IDA		Zfish	PMID:22733817
Biological Process	GO:0031639	plasminogen activation	plaua	IDA		Zfish	PMID:22733817
Biological Process	GO:0030335	positive regulation of cell migration	PLAU	IDA		Human	PMID:25168896
Biological Process	GO:0008284	positive regulation of cell population proliferation	Plau	IMP		Rat	PMID:16899994|RGD:6484216
Biological Process	GO:0060279	positive regulation of ovulation	Plau	IMP		Rat	PMID:10727258|RGD:6484219
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	Plau	IDA		Rat	PMID:16456094|RGD:6484217
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Plau	IMP		Rat	PMID:9315743|RGD:6484218
Biological Process	GO:0030155	regulation of cell adhesion	PLAU	IDA		Human	PMID:10722842
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	PLAU	IDA		Human	PMID:8837777
Biological Process	GO:0042127	regulation of cell population proliferation	Plau	IGI	MGI:MGI:88039	Mouse	PMID:17893885
Biological Process	GO:2000345	regulation of hepatocyte proliferation	Plau	IMP		Rat	PMID:17587687|RGD:6484147
Biological Process	GO:0010469	regulation of signaling receptor activity	PLAU	IDA		Human	PMID:8837777
Biological Process	GO:0014910	regulation of smooth muscle cell migration	PLAU	IDA		Human	PMID:8837777
Biological Process	GO:2000097	regulation of smooth muscle cell-matrix adhesion	PLAU	IDA		Human	PMID:8837777
Biological Process	GO:0014823	response to activity	Plau	IEP		Rat	PMID:22592543|RGD:7241555
Biological Process	GO:0035728	response to hepatocyte growth factor	Plau	IEP		Rat	PMID:21843593|RGD:7241583
Biological Process	GO:0055093	response to hyperoxia	Plau	IEP		Rat	PMID:19099788|RGD:4143526
Biological Process	GO:0001666	response to hypoxia	Plau	IMP		Mouse	PMID:17382917
Biological Process	GO:0043403	skeletal muscle tissue regeneration	Plau	IMP		Rat	PMID:12919869|RGD:1581928
Biological Process	GO:0014909	smooth muscle cell migration	Plau	IMP		Mouse	PMID:17382917
Biological Process	GO:0007283	spermatogenesis	Plau	IEP		Rat	PMID:17712486|RGD:6484143
Biological Process	GO:0042060	wound healing	Plau	IEP		Rat	PMID:12524078|RGD:633572
Biological Process	GO:0042060	wound healing	Plau	IMP		Rat	PMID:15854129|RGD:1581926

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern