Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLCB1
  • Mouse genes Plcb1
  • Rat genes Plcb1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plcb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005246	calcium channel regulator activity	Plcb1	IDA		Mouse	PMID:9762362
Molecular Function	GO:0005509	calcium ion binding	Plcb1	IDA		Rat	PMID:11377826|RGD:8554253
Molecular Function	GO:0005516	calmodulin binding	PLCB1	IDA		Human	PMID:12821674
Molecular Function	GO:0099103	channel activator activity	Plcb1	IDA		Mouse	PMID:9762362
Molecular Function	GO:0019899	enzyme binding	PLCB1	IPI	UniProtKB:P52824	Human	PMID:12799190
Molecular Function	GO:0005096	GTPase activator activity	PLCB1	IDA		Human	PMID:1322796
Molecular Function	GO:0042802	identical protein binding	Plcb1	IPI	RGD:3344	Rat	PMID:16763092|RGD:2314506
Molecular Function	GO:0042802	identical protein binding	Plcb1	IPI	UniProtKB:P10687	Rat	PMID:16763092|RGD:2314506
Molecular Function	GO:0099107	ion channel regulator activity involved in G protein-coupled receptor signaling pathway	Plcb1	IDA		Mouse	PMID:9762362
Molecular Function	GO:0005521	lamin binding	Plcb1	IPI	UniProtKB:P14733	Mouse	MGI:MGI:4943663|PMID:19028838
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	PLCB1	IDA		Human	PMID:9188725
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	Plcb1	IDA		Mouse	PMID:9762362
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	Plcb1	IDA		Rat	PMID:15159145|RGD:1582559
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PLCB1	IDA		Human	PMID:12799190
Molecular Function	GO:0005515	protein binding	PLCB1	IPI	UniProtKB:P56545	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLCB1	IPI	UniProtKB:P56545-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLCB1	IPI	UniProtKB:Q12800	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLCB1	IPI	UniProtKB:Q13363-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLCB1	IPI	UniProtKB:Q8TAP6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Plcb1	IPI	UniProtKB:P84104	Mouse	MGI:MGI:4943667|PMID:17022104
Molecular Function	GO:0005515	protein binding	Plcb1	IPI	UniProtKB:Q925B3	Rat	PMID:11161216|RGD:632429
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	Plcb1	IDA		Mouse	PMID:9762362
Cellular Component	GO:0000785	chromatin	Plcb1	IDA		Mouse	MGI:MGI:4943663|PMID:19028838
Cellular Component	GO:0005737	cytoplasm	PLCB1	IDA		Human	PMID:11118617
Cellular Component	GO:0005737	cytoplasm	Plcb1	IDA		Mouse	MGI:MGI:4943410|PMID:15849202
Cellular Component	GO:0005737	cytoplasm	Plcb1	IDA		Mouse	MGI:MGI:4943666|PMID:17725492
Cellular Component	GO:0005829	cytosol	Plcb1	IDA		Rat	PMID:15159145|RGD:1582559
Cellular Component	GO:0070062	extracellular exosome	PLCB1	HDA		Human	PMID:19199708
Cellular Component	GO:0098982	GABA-ergic synapse	Plcb1	IDA		Mouse	PMID:15664177
Cellular Component	GO:0098982	GABA-ergic synapse	Plcb1	IMP		Mouse	PMID:15664177
Cellular Component	GO:0098978	glutamatergic synapse	Plcb1	EXP		Mouse	PMID:16339037
Cellular Component	GO:0098978	glutamatergic synapse	Plcb1	IDA		Mouse	PMID:16339037
Cellular Component	GO:0098978	glutamatergic synapse	Plcb1	IMP		Mouse	PMID:16339037
Cellular Component	GO:0016020	membrane	Plcb1	IDA		Rat	PMID:15159145|RGD:1582559
Cellular Component	GO:0043209	myelin sheath	Plcb1	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0016607	nuclear speck	PLCB1	IDA		Human	PMID:12799190
Cellular Component	GO:0016607	nuclear speck	Plcb1	IDA		Mouse	MGI:MGI:4943667|PMID:17022104
Cellular Component	GO:0005634	nucleus	Plcb1	IDA		Mouse	MGI:MGI:4942243|PMID:15174099
Cellular Component	GO:0005634	nucleus	Plcb1	IDA		Mouse	MGI:MGI:4942262|PMID:10913438
Cellular Component	GO:0005634	nucleus	Plcb1	IDA		Mouse	MGI:MGI:4943410|PMID:15849202
Cellular Component	GO:0005634	nucleus	Plcb1	IDA		Mouse	MGI:MGI:4943666|PMID:17725492
Cellular Component	GO:0005634	nucleus	Plcb1	IDA		Mouse	MGI:MGI:4942248|PMID:14499343
Cellular Component	GO:0005634	nucleus	Plcb1	IDA		Rat	PMID:1325785|RGD:11535160
Cellular Component	GO:0098794	postsynapse	Plcb1	IDA		Mouse	MGI:MGI:3610682|PMID:16339037
Cellular Component	GO:0099524	postsynaptic cytosol	Plcb1	IDA		Mouse	PMID:18973591
Cellular Component	GO:0099524	postsynaptic cytosol	Plcb1	IEP		Mouse	PMID:18973591
Cellular Component	GO:0032991	protein-containing complex	Plcb1	IDA		Mouse	PMID:27353086
Biological Process	GO:0060466	activation of meiosis involved in egg activation	Plcb1	IDA		Mouse	MGI:MGI:4942248|PMID:14499343
Biological Process	GO:0007420	brain development	Plcb1	IEP		Rat	PMID:9705000|RGD:13830877
Biological Process	GO:1902618	cellular response to fluoride	Plcb1	IDA		Rat	PMID:11377826|RGD:8554253
Biological Process	GO:1905631	cellular response to glyceraldehyde	Plcb1	IDA		Rat	PMID:11377826|RGD:8554253
Biological Process	GO:1904637	cellular response to ionomycin	Plcb1	IDA		Rat	PMID:11377826|RGD:8554253
Biological Process	GO:1904117	cellular response to vasopressin	Plcb1	IDA		Rat	PMID:11377826|RGD:8554253
Biological Process	GO:0021987	cerebral cortex development	Plcb1	IMP		Mouse	MGI:MGI:3628680|PMID:11224545
Biological Process	GO:0045444	fat cell differentiation	Plcb1	IDA		Mouse	MGI:MGI:4943656|PMID:19385066
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	Plcb1	IMP		Mouse	MGI:MGI:1097045|PMID:9305844
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	Plcb1	IDA		Mouse	MGI:MGI:4943663|PMID:19028838
Biological Process	GO:0007215	glutamate receptor signaling pathway	Plcb1	IMP		Mouse	MGI:MGI:3628680|PMID:11224545
Biological Process	GO:0032957	inositol trisphosphate metabolic process	Plcb1	IDA		Rat	PMID:8387502|RGD:11535163
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Plcb1	IDA		Mouse	MGI:MGI:4942268|PMID:9187110
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	PLCB1	IDA		Human	PMID:8872139
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	PLCB1	IDA		Human	PMID:11743656
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	PLCB1	IDA		Human	PMID:11743656
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Plcb1	IMP	MGI:MGI:6460327	Mouse	PMID:31268747
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Plcb1	IMP		Mouse	PMID:26075576
Biological Process	GO:0007612	learning	Plcb1	IEP		Rat	PMID:15159145|RGD:1582559
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Plcb1	IMP	MGI:MGI:6460327	Mouse	PMID:31268747
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Plcb1	IMP		Mouse	PMID:26075576
Biological Process	GO:0007613	memory	Plcb1	IMP		Mouse	MGI:MGI:4943665|PMID:18493969
Biological Process	GO:0007613	memory	Plcb1	IEP		Rat	PMID:15159145|RGD:1582559
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Plcb1	IDA		Mouse	MGI:MGI:4942256|PMID:12031797
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Plcb1	IDA		Mouse	MGI:MGI:4943667|PMID:17022104
Biological Process	GO:2000438	negative regulation of monocyte extravasation	Plcb1	IDA		Mouse	MGI:MGI:4867163|PMID:19687358
Biological Process	GO:0031161	phosphatidylinositol catabolic process	Plcb1	IDA		Rat	PMID:8387502|RGD:11535163
Biological Process	GO:0046488	phosphatidylinositol metabolic process	PLCB1	IDA		Human	PMID:9188725
Biological Process	GO:0046488	phosphatidylinositol metabolic process	Plcb1	IEP		Rat	PMID:12786971|RGD:1299009
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	Plcb1	IMP	MGI:MGI:6460327	Mouse	PMID:31268747
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	Plcb1	IGI	MGI:MGI:88031	Mouse	PMID:10570150
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Plcb1	IMP	MGI:MGI:6460327	Mouse	PMID:31268747
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Plcb1	IMP		Mouse	PMID:26075576
Biological Process	GO:2000344	positive regulation of acrosome reaction	Plcb1	IMP		Mouse	MGI:MGI:2136696|PMID:11464583
Biological Process	GO:2000560	positive regulation of CD24 production	Plcb1	IDA		Mouse	MGI:MGI:4943410|PMID:15849202
Biological Process	GO:0048639	positive regulation of developmental growth	Plcb1	IMP		Mouse	MGI:MGI:3055691|PMID:15474310
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Plcb1	IDA		Mouse	MGI:MGI:4943410|PMID:15849202
Biological Process	GO:0040019	positive regulation of embryonic development	Plcb1	IMP		Mouse	MGI:MGI:2136696|PMID:11464583
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	Plcb1	IDA		Mouse	MGI:MGI:4942262|PMID:10913438
Biological Process	GO:0032024	positive regulation of insulin secretion	Plcb1	IMP	MGI:MGI:6460327	Mouse	PMID:31268747
Biological Process	GO:0032024	positive regulation of insulin secretion	Plcb1	IGI	MGI:MGI:88031	Mouse	PMID:10570150
Biological Process	GO:0032024	positive regulation of insulin secretion	Plcb1	IMP		Mouse	PMID:26075576
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Plcb1	IMP		Mouse	MGI:MGI:4943671|PMID:9444325
Biological Process	GO:0046330	positive regulation of JNK cascade	PLCB1	IDA		Human	PMID:9500449
Biological Process	GO:0045663	positive regulation of myoblast differentiation	Plcb1	IDA		Mouse	MGI:MGI:4942243|PMID:15174099
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Plcb1	IDA		Mouse	PMID:16339037
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Plcb1	IMP		Mouse	PMID:16339037
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Plcb1	EXP		Mouse	PMID:16339037
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	Plcb1	IMP		Mouse	MGI:MGI:5904576|PMID:27653213
Biological Process	GO:0080154	regulation of fertilization	Plcb1	IMP		Mouse	MGI:MGI:2136696|PMID:11464583
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	Plcb1	IMP		Mouse	MGI:MGI:4943665|PMID:18493969
Biological Process	GO:0099178	regulation of retrograde trans-synaptic signaling by endocanabinoid	Plcb1	IDA		Mouse	PMID:15664177
Biological Process	GO:0099178	regulation of retrograde trans-synaptic signaling by endocanabinoid	Plcb1	IMP		Mouse	PMID:15664177
Biological Process	GO:0034284	response to monosaccharide	Plcb1	IDA		Rat	PMID:11377826|RGD:8554253
Biological Process	GO:0010243	response to organonitrogen compound	Plcb1	IEP		Rat	PMID:12850505|RGD:1299008
Biological Process	GO:0043434	response to peptide hormone	Plcb1	IDA		Rat	PMID:11377826|RGD:8554253

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern