Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLCB3
  • Mouse genes Plcb3
  • Rat genes Plcb3
  • Zfish genes plcb3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plcb3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	PLCB3	HDA		Human	PMID:25468996
Molecular Function	GO:0005516	calmodulin binding	PLCB3	IDA		Human	PMID:12821674
Molecular Function	GO:0060090	molecular adaptor activity	PLCB3	EXP		Human	PMID:23377541
Molecular Function	GO:0060090	molecular adaptor activity	PLCB3	IDA		Human	PMID:23377541
Molecular Function	GO:0140677	molecular function activator activity	PLCB3	EXP		Human	PMID:23377541
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	PLCB3	IDA		Human	PMID:9188725
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	Plcb3	IDA		Rat	PMID:8454637|RGD:61699
Molecular Function	GO:0005515	protein binding	PLCB3	IPI	UniProtKB:P21279	Human	PMID:21822282
Molecular Function	GO:0005515	protein binding	PLCB3	IPI	UniProtKB:P21279	Human	PMID:23377541
Molecular Function	GO:0005515	protein binding	Plcb3	IPI	RGD:628772	Rat	PMID:15632121|RGD:2314508
Cellular Component	GO:0005829	cytosol	Plcb3	IDA		Rat	PMID:8454637|RGD:61699
Cellular Component	GO:0099524	postsynaptic cytosol	Plcb3	IDA		Mouse	PMID:17298601
Cellular Component	GO:0099524	postsynaptic cytosol	Plcb3	IEP		Mouse	PMID:17298601
Cellular Component	GO:0032991	protein-containing complex	PLCB3	IDA		Human	PMID:18468998
Cellular Component	GO:0042383	sarcolemma	Plcb3	IDA		Rat	PMID:15362504|RGD:2314509
Biological Process	GO:0060536	cartilage morphogenesis	plcb3	IMP	ZFIN:ZDB-GENO-980202-1030	Zfish	PMID:9007254
Biological Process	GO:0060536	cartilage morphogenesis	plcb3	IMP	ZFIN:ZDB-GENO-980202-1409	Zfish	PMID:9007254
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	plcb3	IGI	ZFIN:ZDB-GENO-070209-215,ZFIN:ZDB-GENO-080226-1	Zfish	PMID:17239364
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	plcb3	IMP	ZFIN:ZDB-GENO-080225-8	Zfish	PMID:17239364
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Plcb3	IMP		Rat	PMID:16314422|RGD:2314523
Biological Process	GO:0032957	inositol trisphosphate metabolic process	Plcb3	IDA		Rat	PMID:8387502|RGD:11535163
Biological Process	GO:0090281	negative regulation of calcium ion import	plcb3	IDA		Zfish	PMID:22674805
Biological Process	GO:0043116	negative regulation of vascular permeability	plcb3	IMP	ZFIN:ZDB-MRPHLNO-080225-4	Zfish	PMID:22674805
Biological Process	GO:0031161	phosphatidylinositol catabolic process	Plcb3	IDA		Rat	PMID:8387502|RGD:11535163
Biological Process	GO:0046488	phosphatidylinositol metabolic process	PLCB3	IDA		Human	PMID:9188725
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	Plcb3	IDA		Rat	PMID:8454637|RGD:61699
Biological Process	GO:0006892	post-Golgi vesicle-mediated transport	Plcb3	IDA		Rat	PMID:17492941|RGD:2314515
Biological Process	GO:0003073	regulation of systemic arterial blood pressure	PLCB3	IDA		Human	PMID:18468998

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern