Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLCD1
  • Mouse genes Plcd1
  • Rat genes Plcd1
  • Zfish genes plcd1a,plcd1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plcd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Plcd1	IMP		Rat	PMID:8602259|RGD:12792989
Molecular Function	GO:0005509	calcium ion binding	Plcd1	IDA		Rat	PMID:9538021|RGD:2301016
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	Plcd1	IMP		Rat	PMID:8602259|RGD:12792989
Molecular Function	GO:0032794	GTPase activating protein binding	PLCD1	IPI	UniProtKB:O43182-4	Human	PMID:18434237
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	Plcd1	IMP		Rat	PMID:8602259|RGD:12792989
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	PLCD1	IDA		Human	PMID:9188725
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	Plcd1	IDA		Rat	PMID:9287165|RGD:2301017
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PLCD1	IDA		Human	PMID:11001876
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PLCD1	IDA		Human	PMID:9188725
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Plcd1	IDA		Rat	PMID:9804818|RGD:2301015
Molecular Function	GO:0005543	phospholipid binding	Plcd1	IDA		Rat	PMID:15755258|RGD:2300427
Molecular Function	GO:0005515	protein binding	PLCD1	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLCD1	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Plcd1	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Plcd1	IPI	RGD:621081	Rat	PMID:16709602|RGD:2300424
Molecular Function	GO:0005515	protein binding	Plcd1	IPI	RGD:68416	Rat	PMID:18157946|RGD:2304072
Cellular Component	GO:0005737	cytoplasm	PLCD1	IDA		Human	PMID:15702972
Cellular Component	GO:0005829	cytosol	Plcd1	IDA		Mouse	PMID:15899900
Cellular Component	GO:0005829	cytosol	Plcd1	IDA		Rat	PMID:16709602|RGD:2300424
Cellular Component	GO:0070062	extracellular exosome	PLCD1	HDA		Human	PMID:19056867
Cellular Component	GO:0016020	membrane	Plcd1	IDA		Rat	PMID:16709602|RGD:2300424
Cellular Component	GO:0045121	membrane raft	Plcd1	IDA		Rat	PMID:18157946|RGD:2304072
Cellular Component	GO:0031966	mitochondrial membrane	Plcd1	IDA		Rat	PMID:15107298|RGD:1304325
Cellular Component	GO:0005634	nucleus	Plcd1	IDA		Rat	PMID:16115628|RGD:2300425
Biological Process	GO:0001525	angiogenesis	Plcd1	IGI	MGI:MGI:107451	Mouse	PMID:16314520
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Plcd1	IDA		Rat	PMID:8663582|RGD:2301018
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Plcd1	IGI	MGI:MGI:107451	Mouse	PMID:16314520
Biological Process	GO:0046488	phosphatidylinositol metabolic process	PLCD1	IDA		Human	PMID:9188725
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	Plcd1	IMP		Rat	PMID:16709602|RGD:2300424
Biological Process	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process	Plcd1	IMP		Rat	PMID:16709602|RGD:2300424
Biological Process	GO:0010701	positive regulation of norepinephrine secretion	Plcd1	IMP		Rat	PMID:10473563|RGD:2301014
Biological Process	GO:0042127	regulation of cell population proliferation	Plcd1	IGI	MGI:MGI:107451	Mouse	PMID:16314520
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	Plcd1	IMP		Rat	PMID:21767260|RGD:7349319
Biological Process	GO:1900274	regulation of phospholipase C activity	Plcd1	IMP		Rat	PMID:21767260|RGD:7349319
Biological Process	GO:0010044	response to aluminum ion	Plcd1	IEP		Rat	PMID:10814511|RGD:2300432
Biological Process	GO:0051592	response to calcium ion	Plcd1	IMP		Rat	PMID:10473563|RGD:2301014
Biological Process	GO:0055093	response to hyperoxia	Plcd1	IEP		Rat	PMID:12850505|RGD:1299008
Biological Process	GO:0010243	response to organonitrogen compound	Plcd1	IEP		Rat	PMID:12850505|RGD:1299008
Biological Process	GO:0043434	response to peptide hormone	Plcd1	IMP		Rat	PMID:16709602|RGD:2300424
Biological Process	GO:0034696	response to prostaglandin F	Plcd1	IEP		Rat	PMID:11517196|RGD:2300430

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern