Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLCE1
  • Mouse genes Plce1
  • Rat genes Plce1
  • Zfish genes plce1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plce1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	PLCE1	IPI	UniProtKB:P01112	Human	PMID:11022048
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	PLCE1	IDA		Human	PMID:11022047
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	PLCE1	IDA		Human	PMID:11022048
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	Plce1	IDA		Rat	PMID:11179219|RGD:68714
Molecular Function	GO:0004629	phospholipase C activity	PLCE1	IDA		Human	PMID:11022047
Molecular Function	GO:0005515	protein binding	PLCE1	IPI	UniProtKB:P62834	Human	PMID:11022048
Molecular Function	GO:0005515	protein binding	PLCE1	IPI	UniProtKB:O75366	Human	PMID:29058690
Molecular Function	GO:0005515	protein binding	Plce1	IPI	UniProtKB:E9Q401	Mouse	MGI:MGI:5491968|PMID:23540699
Molecular Function	GO:0031267	small GTPase binding	PLCE1	IDA		Human	PMID:11022048
Molecular Function	GO:0031267	small GTPase binding	Plce1	IDA		Rat	PMID:11179219|RGD:68714
Cellular Component	GO:0005737	cytoplasm	Plce1	IDA		Rat	PMID:1651229|RGD:7257522
Cellular Component	GO:0005829	cytosol	PLCE1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	PLCE1	IDA		Human	PMID:11022048
Cellular Component	GO:0030027	lamellipodium	PLCE1	IDA		Human	PMID:29058690
Cellular Component	GO:0005886	plasma membrane	PLCE1	IDA		Human	PMID:11022048
Biological Process	GO:0006651	diacylglycerol biosynthetic process	PLCE1	IMP		Human	PMID:29058690
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	PLCE1	IMP		Human	PMID:29058690
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Plce1	IMP		Rat	PMID:16314422|RGD:2314523
Biological Process	GO:0032836	glomerular basement membrane development	plce1	IMP	ZFIN:ZDB-MRPHLNO-061213-1	Zfish	PMID:17086182
Biological Process	GO:0032835	glomerulus development	PLCE1	IMP		Human	PMID:17086182
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	PLCE1	IDA		Human	PMID:11022047
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	PLCE1	IDA		Human	PMID:11022048
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	PLCE1	IMP		Human	PMID:29058690
Biological Process	GO:0043410	positive regulation of MAPK cascade	PLCE1	IDA		Human	PMID:11022047
Biological Process	GO:0007265	Ras protein signal transduction	PLCE1	IDA		Human	PMID:11022048
Biological Process	GO:0007265	Ras protein signal transduction	Plce1	IDA		Rat	PMID:11179219|RGD:68714
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	PLCE1	IDA		Human	PMID:11022047
Biological Process	GO:0045859	regulation of protein kinase activity	PLCE1	IDA		Human	PMID:11022047
Biological Process	GO:0046578	regulation of Ras protein signal transduction	PLCE1	IDA		Human	PMID:11022047

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern