Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Plcg2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PLCG2
- Mouse genes Plcg2
- Rat genes Plcg2
- Zfish genes plcg2,si:ch211-260p9.3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plcg2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	PLCG2	IDA		Human	PMID:11606584
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	PLCG2	IDA		Human	PMID:12181444
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	PLCG2	IMP		Human	PMID:32514138
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	Plcg2	EXP		Mouse	MGI:MGI:6218355\|PMID:8615781
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	Plcg2	IDA		Rat	PMID:2557343\|RGD:69934
Molecular Function	GO:0140031	phosphorylation-dependent protein binding	Plcg2	IPI	UniProtKB:Q9QZE2	Mouse	MGI:MGI:2179131\|PMID:10744659
Molecular Function	GO:0001784	phosphotyrosine residue binding	PLCG2	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:P19235	Human	PMID:15644415
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:O14796	Human	PMID:24642916
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:P10275	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:P00533	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:P04626	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:O43242	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:O95073-2	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	PLCG2	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	Plcg2	IPI	UniProtKB:O70433\|UniProtKB:P11276\|UniProtKB:Q62158\|UniProtKB:Q64321\|UniProtKB:Q8BTM8\|UniProtKB:Q9ES52\|UniProtKB:Q9WU78	Mouse	MGI:MGI:3688344\|PMID:15102471
Molecular Function	GO:0005515	protein binding	Plcg2	IPI	UniProtKB:P25911	Mouse	MGI:MGI:5508323\|PMID:8395016
Molecular Function	GO:0005515	protein binding	Plcg2	IPI	UniProtKB:P25911,UniProtKB:Q60631,UniProtKB:Q91YX0	Mouse	MGI:MGI:5775861\|PMID:24907343
Molecular Function	GO:0005515	protein binding	Plcg2	IPI	UniProtKB:P14753	Mouse	MGI:MGI:3689794\|PMID:15953601
Molecular Function	GO:0005515	protein binding	Plcg2	IPI	PR:000049793	Mouse	PMID:27609517
Molecular Function	GO:0005515	protein binding	Plcg2	IPI	UniprotKB:Q60787	Mouse	PMID:27609517
Molecular Function	GO:0005515	protein binding	Plcg2	IPI	PR:Q9EQR5	Mouse	PMID:16249387
Molecular Function	GO:0005515	protein binding	Plcg2	IPI	UniProtKB:Q9YGC1	Rat	PMID:11507089\|RGD:2303039
Molecular Function	GO:0019901	protein kinase binding	PLCG2	IPI	UniProtKB:P06239	Human	PMID:11606584
Molecular Function	GO:0019901	protein kinase binding	PLCG2	IPI	UniProtKB:P06241	Human	PMID:11606584
Molecular Function	GO:0019901	protein kinase binding	PLCG2	IPI	UniProtKB:P12931	Human	PMID:11606584
Molecular Function	GO:0019901	protein kinase binding	PLCG2	IPI	UniProtKB:Q06187	Human	PMID:11606584
Molecular Function	GO:0019901	protein kinase binding	PLCG2	IPI	UniProtKB:P43405	Human	PMID:14656219
Molecular Function	GO:0019901	protein kinase binding	PLCG2	IPI	UniProtKB:Q06187	Human	PMID:14656219
Molecular Function	GO:1990782	protein tyrosine kinase binding	PLCG2	IPI	UniProtKB:P43405	Human	PMID:32514138
Molecular Function	GO:0097110	scaffold protein binding	PLCG2	IPI	UniProtKB:Q8WV28	Human	PMID:11606584
Molecular Function	GO:0097110	scaffold protein binding	PLCG2	IPI	UniProtKB:Q9YGC1	Human	PMID:11606584
Molecular Function	GO:0097110	scaffold protein binding	PLCG2	IPI	UniProtKB:Q8NDB2	Human	PMID:23555801
Cellular Component	GO:0005737	cytoplasm	PLCG2	IDA		Human	PMID:11331309
Cellular Component	GO:0005829	cytosol	Plcg2	IMP		Mouse	MGI:MGI:1861532\|PMID:10925250
Cellular Component	GO:0070062	extracellular exosome	PLCG2	HDA		Human	PMID:20458337
Cellular Component	GO:0097708	intracellular vesicle	PLCG2	IDA		Human	PMID:11331309
Cellular Component	GO:0016020	membrane	Plcg2	IDA		Rat	PMID:8958450\|RGD:2303040
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PLCG2	IDA		Human	PMID:23555801
Cellular Component	GO:0005886	plasma membrane	PLCG2	IDA		Human	PMID:11331309
Cellular Component	GO:0005886	plasma membrane	PLCG2	IDA		Human	PMID:11606584
Cellular Component	GO:0032587	ruffle membrane	PLCG2	IDA		Human	PMID:11331309
Biological Process	GO:0032237	activation of store-operated calcium channel activity	Plcg2	IMP		Mouse	PMID:15611229
Biological Process	GO:0061760	antifungal innate immune response	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0030183	B cell differentiation	Plcg2	IMP		Mouse	MGI:MGI:1861532\|PMID:10925250
Biological Process	GO:0050853	B cell receptor signaling pathway	PLCG2	IMP		Human	PMID:11606584
Biological Process	GO:0050853	B cell receptor signaling pathway	PLCG2	IDA		Human	PMID:15509800
Biological Process	GO:0050853	B cell receptor signaling pathway	Plcg2	IMP		Mouse	MGI:MGI:1861532\|PMID:10925250
Biological Process	GO:0019722	calcium-mediated signaling	PLCG2	IMP		Human	PMID:11606584
Biological Process	GO:0001775	cell activation	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0071277	cellular response to calcium ion	PLCG2	IMP		Human	PMID:11606584
Biological Process	GO:1990858	cellular response to lectin	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0071396	cellular response to lipid	PLCG2	IMP		Human	PMID:32514138
Biological Process	GO:0002316	follicular B cell differentiation	Plcg2	IMP	MGI:MGI:2386100	Mouse	PMID:12928432
Biological Process	GO:0032959	inositol trisphosphate biosynthetic process	Plcg2	IDA		Mouse	PMID:9013981
Biological Process	GO:0035556	intracellular signal transduction	PLCG2	IDA		Human	PMID:11606584
Biological Process	GO:0035556	intracellular signal transduction	PLCG2	IDA		Human	PMID:14656219
Biological Process	GO:0035556	intracellular signal transduction	PLCG2	IMP		Human	PMID:32514138
Biological Process	GO:0035556	intracellular signal transduction	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0035556	intracellular signal transduction	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0035556	intracellular signal transduction	Plcg2	IMP		Rat	PMID:31549850\|RGD:126781738
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	PLCG2	IMP		Human	PMID:32514138
Biological Process	GO:0002281	macrophage activation involved in immune response	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0043069	negative regulation of programmed cell death	Plcg2	IMP	MGI:MGI:2386100	Mouse	PMID:12928432
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process	PLCG2	IDA		Human	PMID:11606584
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process	PLCG2	IDA		Human	PMID:12181444
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition	Plcg2	IDA		Rat	PMID:31549850\|RGD:126781738
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Plcg2	IMP		Rat	PMID:11507089\|RGD:2303039
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Plcg2	IMP		Rat	PMID:31549850\|RGD:126781738
Biological Process	GO:0010628	positive regulation of gene expression	PLCG2	IMP		Human	PMID:32514138
Biological Process	GO:0010628	positive regulation of gene expression	Plcg2	IMP		Rat	PMID:31549850\|RGD:126781738
Biological Process	GO:1903721	positive regulation of I-kappaB phosphorylation	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0032743	positive regulation of interleukin-2 production	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0032747	positive regulation of interleukin-23 production	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0043410	positive regulation of MAPK cascade	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0043410	positive regulation of MAPK cascade	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	PLCG2	IMP		Human	PMID:32514138
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	PLCG2	IMP		Human	PMID:32514138
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	PLCG2	IMP		Human	PMID:32514138
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0002092	positive regulation of receptor internalization	Plcg2	IMP		Mouse	MGI:MGI:5300392\|PMID:22078883
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0032481	positive regulation of type I interferon production	Plcg2	IMP		Mouse	MGI:MGI:5300392\|PMID:22078883
Biological Process	GO:0012501	programmed cell death	Plcg2	IMP	MGI:MGI:2386100	Mouse	PMID:12928432
Biological Process	GO:0070884	regulation of calcineurin-NFAT signaling cascade	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0010468	regulation of gene expression	Plcg2	IMP	MGI:MGI:2386100	Mouse	PMID:12928432
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0019216	regulation of lipid metabolic process	PLCG2	IMP		Human	PMID:32514138
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	PLCG2	IDA		Human	PMID:11606584
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Plcg2	IMP		Mouse	MGI:MGI:1861532\|PMID:10925250
Biological Process	GO:0033198	response to ATP	Plcg2	IDA		Rat	PMID:8958450\|RGD:2303040
Biological Process	GO:0048678	response to axon injury	PLCG2	IMP		Human	PMID:32514138
Biological Process	GO:0032496	response to lipopolysaccharide	Plcg2	IDA		Mouse	PMID:9013981
Biological Process	GO:0032026	response to magnesium ion	Plcg2	IDA		Rat	PMID:8958450\|RGD:2303040
Biological Process	GO:0001878	response to yeast	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Plcg2	IMP		Mouse	MGI:MGI:5300086\|PMID:22041900
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564
Biological Process	GO:0050852	T cell receptor signaling pathway	Plcg2	IDA		Mouse	PMID:15728238
Biological Process	GO:0002224	toll-like receptor signaling pathway	Plcg2	IMP		Mouse	MGI:MGI:3844414\|PMID:19136564

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.