Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLCL2
  • Mouse genes Plcl2
  • Rat genes Plcl2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plcl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050811	GABA receptor binding	PLCL2	IDA		Human	PMID:16754670
Molecular Function	GO:0005515	protein binding	PLCL2	IPI	UniProtKB:P01112	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PLCL2	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PLCL2	IPI	UniProtKB:P22607	Human	PMID:32814053
Biological Process	GO:0002322	B cell proliferation involved in immune response	Plcl2	IMP	MGI:MGI:2679632	Mouse	PMID:14517301
Biological Process	GO:0002337	B-1a B cell differentiation	Plcl2	IMP	MGI:MGI:2679632	Mouse	PMID:14517301
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	Plcl2	IGI	MGI:MGI:3036262	Mouse	PMID:16754670
Biological Process	GO:0050859	negative regulation of B cell receptor signaling pathway	Plcl2	IMP	MGI:MGI:2679632	Mouse	PMID:14517301
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Plcl2	IGI	UniProtKB:Q3USB7	Mouse	MGI:MGI:5766689|PMID:26706316
Biological Process	GO:1900122	positive regulation of receptor binding	Plcl2	IGI	MGI:MGI:3036262	Mouse	PMID:16754670
Biological Process	GO:0032228	regulation of synaptic transmission, GABAergic	Plcl2	IGI	MGI:MGI:3036262	Mouse	PMID:16754670

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern