Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLEK
  • Mouse genes Plek
  • Rat genes Plek
  • Zfish genes plek
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plek

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	PLEK	IDA		Human	PMID:15698571
Molecular Function	GO:0005515	protein binding	PLEK	IPI	UniProtKB:O95810	Human	PMID:19722192
Molecular Function	GO:0005515	protein binding	PLEK	IPI	UniProtKB:Q14642	Human	PMID:8999861
Molecular Function	GO:0042803	protein homodimerization activity	PLEK	IDA		Human	PMID:8694752
Molecular Function	GO:0005080	protein kinase C binding	PLEK	IDA		Human	PMID:8615792
Cellular Component	GO:0005737	cytoplasm	PLEK	IDA		Human	PMID:8694752
Cellular Component	GO:0005737	cytoplasm	PLEK	IDA		Human	PMID:9060471
Cellular Component	GO:0016020	membrane	PLEK	HDA		Human	PMID:19946888
Cellular Component	GO:0032587	ruffle membrane	PLEK	IDA		Human	PMID:9060471
Biological Process	GO:0031532	actin cytoskeleton reorganization	PLEK	IDA		Human	PMID:10497244
Biological Process	GO:0030030	cell projection organization	PLEK	IDA		Human	PMID:9060471
Biological Process	GO:0030866	cortical actin cytoskeleton organization	PLEK	IDA		Human	PMID:10497244
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	PLEK	IEP		Human	PMID:2768345
Biological Process	GO:0007229	integrin-mediated signaling pathway	PLEK	IDA		Human	PMID:10995449
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	PLEK	IDA		Human	PMID:7782310
Biological Process	GO:0010920	negative regulation of inositol phosphate biosynthetic process	PLEK	IDA		Human	PMID:7559487
Biological Process	GO:0010920	negative regulation of inositol phosphate biosynthetic process	PLEK	IDA		Human	PMID:7782310
Biological Process	GO:0046488	phosphatidylinositol metabolic process	PLEK	IDA		Human	PMID:7559487
Biological Process	GO:0030845	phospholipase C-inhibiting G protein-coupled receptor signaling pathway	PLEK	IDA		Human	PMID:7782310
Biological Process	GO:0070527	platelet aggregation	PLEK	HMP		Human	PMID:23382103
Biological Process	GO:0070527	platelet aggregation	Plek	IMP		Mouse	MGI:MGI:3844782|PMID:19190246
Biological Process	GO:0002576	platelet degranulation	PLEK	IEP		Human	PMID:7559487
Biological Process	GO:0032233	positive regulation of actin filament bundle assembly	PLEK	IDA		Human	PMID:10497244
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	PLEK	IDA		Human	PMID:10497244
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	Plek	IMP		Mouse	MGI:MGI:3844782|PMID:19190246
Biological Process	GO:0010925	positive regulation of inositol-polyphosphate 5-phosphatase activity	PLEK	IDA		Human	PMID:8999861
Biological Process	GO:0033625	positive regulation of integrin activation	Plek	IMP		Mouse	MGI:MGI:3844782|PMID:19190246
Biological Process	GO:0010572	positive regulation of platelet activation	Plek	IMP		Mouse	MGI:MGI:3844782|PMID:19190246
Biological Process	GO:0070528	protein kinase C signaling	Plek	IMP		Mouse	MGI:MGI:3844782|PMID:19190246
Biological Process	GO:0070560	protein secretion by platelet	Plek	IMP		Mouse	MGI:MGI:3844782|PMID:19190246
Biological Process	GO:0060305	regulation of cell diameter	PLEK	IDA		Human	PMID:10995449
Biological Process	GO:0031529	ruffle organization	PLEK	IDA		Human	PMID:10497244
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	PLEK	IDA		Human	PMID:7782310
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	Plek	IMP		Mouse	MGI:MGI:3844782|PMID:19190246
Biological Process	GO:0006904	vesicle docking involved in exocytosis	Plek	IMP		Mouse	MGI:MGI:3844782|PMID:19190246

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern