Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLEKHG5
  • Mouse genes Plekhg5
  • Rat genes Plekhg5
  • Zfish genes plekhg5a,plekhg5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plekhg5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Plekhg5	IDA		Mouse	PMID:16467373
Molecular Function	GO:0005515	protein binding	Plekhg5	IPI	PR:Q8K371	Mouse	PMID:18824598
Molecular Function	GO:0005515	protein binding	Plekhg5	IPI	PR:Q9D4H4	Mouse	PMID:18824598
Molecular Function	GO:0005515	protein binding	Plekhg5	IPI	PR:Q64331	Mouse	PMID:16467373
Molecular Function	GO:0005515	protein binding	Plekhg5	IPI	PR:Q9Z0G0	Mouse	PMID:16467373
Molecular Function	GO:0005515	protein binding	Plekhg5	IPI	PR:Q8VHG2	Mouse	PMID:18824598
Molecular Function	GO:0005515	protein binding	Plekhg5	IPI	UniProtKB:Q9Z254	Rat	PMID:16467373|RGD:8553644
Cellular Component	GO:0005911	cell-cell junction	Plekhg5	IDA		Mouse	MGI:MGI:5508725|PMID:21543326
Cellular Component	GO:0005737	cytoplasm	Plekhg5	IDA		Mouse	MGI:MGI:5508725|PMID:21543326
Cellular Component	GO:0005737	cytoplasm	Plekhg5	IDA		Mouse	PMID:16467373
Cellular Component	GO:0030139	endocytic vesicle	Plekhg5	IDA		Mouse	MGI:MGI:5508725|PMID:21543326
Cellular Component	GO:0030027	lamellipodium	Plekhg5	IDA		Mouse	MGI:MGI:5508725|PMID:21543326
Cellular Component	GO:0005886	plasma membrane	Plekhg5	IDA		Mouse	PMID:16467373
Cellular Component	GO:0098793	presynapse	Plekhg5	IDA		Mouse	MGI:MGI:6099896|PMID:29084947
Cellular Component	GO:0045202	synapse	Plekhg5	IDA		Mouse	MGI:MGI:6099896|PMID:29084947
Biological Process	GO:0001525	angiogenesis	plekhg5a	IMP	ZFIN:ZDB-MRPHLNO-090817-3	Zfish	PMID:18824598
Biological Process	GO:0001525	angiogenesis	plekhg5a	IMP	ZFIN:ZDB-MRPHLNO-090421-2	Zfish	PMID:18757825
Biological Process	GO:0001525	angiogenesis	plekhg5a	IMP	ZFIN:ZDB-MRPHLNO-090817-4	Zfish	PMID:18824598
Biological Process	GO:0001525	angiogenesis	plekhg5a	IGI	ZFIN:ZDB-MRPHLNO-070906-15,ZFIN:ZDB-MRPHLNO-090421-1	Zfish	PMID:18757825
Biological Process	GO:0001525	angiogenesis	plekhg5a	IMP	ZFIN:ZDB-MRPHLNO-090421-1	Zfish	PMID:18757825
Biological Process	GO:0001525	angiogenesis	plekhg5a	IGI	ZFIN:ZDB-MRPHLNO-090817-3,ZFIN:ZDB-MRPHLNO-090908-5	Zfish	PMID:18824598
Biological Process	GO:0001525	angiogenesis	plekhg5b	IGI	ZFIN:ZDB-MRPHLNO-090817-3,ZFIN:ZDB-MRPHLNO-090908-5	Zfish	PMID:18824598
Biological Process	GO:0001525	angiogenesis	plekhg5b	IMP	ZFIN:ZDB-MRPHLNO-090908-5	Zfish	PMID:18824598
Biological Process	GO:0001525	angiogenesis	plekhg5b	IGI	ZFIN:ZDB-MRPHLNO-070906-14,ZFIN:ZDB-MRPHLNO-090908-5	Zfish	PMID:18824598
Biological Process	GO:0001525	angiogenesis	plekhg5b	IMP	ZFIN:ZDB-MRPHLNO-090908-6	Zfish	PMID:18824598
Biological Process	GO:0043534	blood vessel endothelial cell migration	plekhg5a	IMP	ZFIN:ZDB-MRPHLNO-090817-3	Zfish	PMID:18824598
Biological Process	GO:0043534	blood vessel endothelial cell migration	plekhg5a	IMP	ZFIN:ZDB-MRPHLNO-090817-4	Zfish	PMID:18824598
Biological Process	GO:0043534	blood vessel endothelial cell migration	plekhg5a	IGI	ZFIN:ZDB-MRPHLNO-090817-3,ZFIN:ZDB-MRPHLNO-090908-5	Zfish	PMID:18824598
Biological Process	GO:0043534	blood vessel endothelial cell migration	plekhg5b	IGI	ZFIN:ZDB-MRPHLNO-070906-14,ZFIN:ZDB-MRPHLNO-090908-5	Zfish	PMID:18824598
Biological Process	GO:0043534	blood vessel endothelial cell migration	plekhg5b	IGI	ZFIN:ZDB-MRPHLNO-090817-3,ZFIN:ZDB-MRPHLNO-090908-5	Zfish	PMID:18824598
Biological Process	GO:0043534	blood vessel endothelial cell migration	plekhg5b	IMP	ZFIN:ZDB-MRPHLNO-090908-5	Zfish	PMID:18824598
Biological Process	GO:0043534	blood vessel endothelial cell migration	plekhg5b	IMP	ZFIN:ZDB-MRPHLNO-090908-6	Zfish	PMID:18824598
Biological Process	GO:0035767	endothelial cell chemotaxis	Plekhg5	IMP		Mouse	MGI:MGI:5508725|PMID:21543326
Biological Process	GO:0043542	endothelial cell migration	Plekhg5	IDA		Mouse	PMID:16467373
Biological Process	GO:0007369	gastrulation	plekhg5a	IMP	ZFIN:ZDB-MRPHLNO-090421-1	Zfish	PMID:20811643
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PLEKHG5	HMP		Human	PMID:12761501
Biological Process	GO:0140251	regulation protein catabolic process at presynapse	Plekhg5	IDA		Mouse	PMID:29084947
Biological Process	GO:0140251	regulation protein catabolic process at presynapse	Plekhg5	IMP		Mouse	PMID:29084947
Biological Process	GO:0140251	regulation protein catabolic process at presynapse	Plekhg5	IPI		Mouse	PMID:29084947

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern