Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Plk2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PLK2
- Mouse genes Plk2
- Rat genes Plk2
- Zfish genes plk2a,plk2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043008	ATP-dependent protein binding	PLK2	IDA		Human	PMID:23983262
Molecular Function	GO:0051117	ATPase binding	Plk2	IPI	RGD:621594	Rat	PMID:20802490\|RGD:152995511
Molecular Function	GO:0032050	clathrin heavy chain binding	Plk2	IPI	RGD:2364	Rat	PMID:20802490\|RGD:152995511
Molecular Function	GO:0051020	GTPase binding	Plk2	IPI	RGD:2513	Rat	PMID:20802490\|RGD:152995511
Molecular Function	GO:0051020	GTPase binding	Plk2	IPI	RGD:620416	Rat	PMID:20802490\|RGD:152995511
Molecular Function	GO:0051020	GTPase binding	Plk2	IPI	RGD:727949	Rat	PMID:20802490\|RGD:152995511
Molecular Function	GO:0005515	protein binding	PLK2	IPI	UniProtKB:P06748	Human	PMID:20352051
Molecular Function	GO:0005515	protein binding	PLK2	IPI	UniProtKB:Q9HC77	Human	PMID:20531387
Molecular Function	GO:0005515	protein binding	PLK2	IPI	UniProtKB:Q86Y33	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Plk2	IPI	UniProtKB:Q9R010	Rat	PMID:10523297\|RGD:61555
Molecular Function	GO:0005515	protein binding	Plk2	IPI	UniProtKB:O35412	Rat	PMID:18498738\|RGD:8553496
Molecular Function	GO:0005515	protein binding	Plk2	IPI	RGD:708497	Rat	PMID:18723513\|RGD:7241135
Molecular Function	GO:0005515	protein binding	Plk2	IPI	RGD:71096	Rat	PMID:20802490\|RGD:152995511
Molecular Function	GO:0005515	protein binding	Plk2	IPI	UniProtKB:F1M386	Rat	PMID:21382555\|RGD:7241548
Molecular Function	GO:0005515	protein binding	Plk2	IPI	UniProtKB:O35412	Rat	PMID:21382555\|RGD:7241548
Molecular Function	GO:0005515	protein binding	Plk2	IPI	UniProtKB:P28818	Rat	PMID:21382555\|RGD:7241548
Molecular Function	GO:0005515	protein binding	Plk2	IPI	UniProtKB:Q9QUH6	Rat	PMID:21382555\|RGD:7241548
Molecular Function	GO:0019901	protein kinase binding	Plk2	IPI	RGD:2064	Rat	PMID:20802490\|RGD:152995511
Molecular Function	GO:0019901	protein kinase binding	Plk2	IPI	RGD:71015	Rat	PMID:20802490\|RGD:152995511
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK2	IDA		Human	PMID:19001868
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK2	IDA		Human	PMID:20352051
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK2	IDA		Human	PMID:20531387
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK2	IDA		Human	PMID:23983262
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Plk2	IDA		Mouse	MGI:MGI:5306318\|PMID:12897130
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Plk2	IDA		Rat	PMID:18498738\|RGD:8553496
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Plk2	IDA		Rat	PMID:21382555\|RGD:7241548
Molecular Function	GO:0044877	protein-containing complex binding	Plk2	IPI	RGD:708497	Rat	PMID:18723513\|RGD:7241135
Cellular Component	GO:0005814	centriole	PLK2	IDA		Human	PMID:19001868
Cellular Component	GO:0005813	centrosome	PLK2	IDA		Human	PMID:15242618
Cellular Component	GO:0000785	chromatin	Plk2	IDA		Mouse	PMID:22854038
Cellular Component	GO:0005737	cytoplasm	PLK2	IDA		Human	PMID:23983262
Cellular Component	GO:0030425	dendrite	Plk2	IDA		Rat	PMID:10523297\|RGD:61555
Cellular Component	GO:0045202	synapse	Plk2	IDA		Rat	PMID:20802490\|RGD:152995511
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	PLK2	IMP		Human	PMID:15242618
Biological Process	GO:0060292	long-term synaptic depression	Plk2	IDA		Rat	PMID:21382555\|RGD:7241548
Biological Process	GO:0060291	long-term synaptic potentiation	Plk2	IDA		Rat	PMID:21382555\|RGD:7241548
Biological Process	GO:0007613	memory	Plk2	IMP		Mouse	MGI:MGI:5140682\|PMID:21382555
Biological Process	GO:0000278	mitotic cell cycle	Plk2	IMP	MGI:MGI:2678106	Mouse	PMID:12972611
Biological Process	GO:0007052	mitotic spindle organization	PLK2	IDA		Human	PMID:19001868
Biological Process	GO:0007052	mitotic spindle organization	Plk2	IMP		Mouse	MGI:MGI:5306318\|PMID:12897130
Biological Process	GO:0016525	negative regulation of angiogenesis	Plk2	IMP		Mouse	MGI:MGI:5766647\|PMID:26934179
Biological Process	GO:0043066	negative regulation of apoptotic process	Plk2	IMP		Mouse	PMID:12897130
Biological Process	GO:0071866	negative regulation of apoptotic process in bone marrow cell	Plk2	IMP		Mouse	MGI:MGI:6120300\|PMID:27908889
Biological Process	GO:2000773	negative regulation of cellular senescence	Plk2	IMP		Mouse	MGI:MGI:6120300\|PMID:27908889
Biological Process	GO:0061000	negative regulation of dendritic spine development	Plk2	IMP		Rat	PMID:18723513\|RGD:7241135
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	Plk2	IMP		Rat	PMID:20802490\|RGD:152995511
Biological Process	GO:0032091	negative regulation of protein binding	Plk2	IMP		Rat	PMID:20802490\|RGD:152995511
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	Plk2	IMP		Rat	PMID:20802490\|RGD:152995511
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PLK2	IDA		Human	PMID:23983262
Biological Process	GO:0010508	positive regulation of autophagy	PLK2	IDA		Human	PMID:23983262
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	Plk2	IMP		Mouse	MGI:MGI:6120300\|PMID:27908889
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PLK2	HMP		Human	PMID:12761501
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Plk2	IMP		Rat	PMID:18723513\|RGD:7241135
Biological Process	GO:0032092	positive regulation of protein binding	Plk2	IDA		Rat	PMID:18723513\|RGD:7241135
Biological Process	GO:0045732	positive regulation of protein catabolic process	PLK2	IDA		Human	PMID:23983262
Biological Process	GO:0002092	positive regulation of receptor internalization	Plk2	IMP		Rat	PMID:20802490\|RGD:152995511
Biological Process	GO:0006468	protein phosphorylation	PLK2	IDA		Human	PMID:20352051
Biological Process	GO:0006468	protein phosphorylation	Plk2	IDA		Mouse	MGI:MGI:5306318\|PMID:12897130
Biological Process	GO:0006468	protein phosphorylation	Plk2	IDA		Rat	PMID:21382555\|RGD:7241548
Biological Process	GO:0032486	Rap protein signal transduction	Plk2	IDA		Rat	PMID:21382555\|RGD:7241548
Biological Process	GO:0007265	Ras protein signal transduction	Plk2	IDA		Rat	PMID:21382555\|RGD:7241548
Biological Process	GO:0046599	regulation of centriole replication	PLK2	IMP		Human	PMID:15242618
Biological Process	GO:0046599	regulation of centriole replication	PLK2	IDA		Human	PMID:19001868
Biological Process	GO:0046599	regulation of centriole replication	PLK2	IDA		Human	PMID:20352051
Biological Process	GO:0046599	regulation of centriole replication	PLK2	IDA		Human	PMID:20531387
Biological Process	GO:0048167	regulation of synaptic plasticity	Plk2	IMP		Mouse	MGI:MGI:5140682\|PMID:21382555
Biological Process	GO:0048167	regulation of synaptic plasticity	Plk2	IMP		Rat	PMID:18498738\|RGD:8553496
Biological Process	GO:0048167	regulation of synaptic plasticity	Plk2	IDA		Rat	PMID:21382555\|RGD:7241548
Biological Process	GO:0002040	sprouting angiogenesis	plk2b	IMP	ZFIN:ZDB-MRPHLNO-151125-1	Zfish	PMID:26004360

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.