Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLK3
  • Mouse genes Plk3
  • Rat genes Plk3
  • Zfish genes plk3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plk3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0002039	p53 binding	PLK3	IDA		Human	PMID:11447225
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:P30307	Human	PMID:14968113
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:Q14789	Human	PMID:14980500
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:O96017	Human	PMID:16481012
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:P04156	Human	PMID:18482256
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:Q99986	Human	PMID:19103756
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:O15350	Human	PMID:19490146
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:Q16665	Human	PMID:20889502
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:Q99828	Human	PMID:20951827
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:P15336	Human	PMID:21098032
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:Q99828	Human	PMID:21264284
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:P30304	Human	PMID:21376736
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:Q07817	Human	PMID:21840391
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:P14859	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:P43351	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:Q8WVD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:Q9GZY8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK3	IPI	UniProtKB:Q9Y4Y9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Plk3	IPI	UniProtKB:O08586	Mouse	MGI:MGI:5298335|PMID:20940307
Molecular Function	GO:0005515	protein binding	Plk3	IPI	RGD:620133	Rat	PMID:10523297|RGD:61555
Molecular Function	GO:0005515	protein binding	Plk3	IPI	UniProtKB:Q9R010	Rat	PMID:10523297|RGD:61555
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK3	IDA		Human	PMID:11447225
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK3	IDA		Human	PMID:14968113
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK3	IDA		Human	PMID:16481012
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK3	IDA		Human	PMID:19103756
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK3	IDA		Human	PMID:20889502
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK3	IDA		Human	PMID:21098032
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK3	IDA		Human	PMID:21376736
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK3	IDA		Human	PMID:21840391
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Plk3	IDA		Mouse	MGI:MGI:5298335|PMID:20940307
Cellular Component	GO:0005813	centrosome	PLK3	IDA		Human	PMID:16478733
Cellular Component	GO:0005813	centrosome	PLK3	IDA		Human	PMID:20951827
Cellular Component	GO:0000785	chromatin	Plk3	IDA		Mouse	PMID:22854038
Cellular Component	GO:0005737	cytoplasm	PLK3	IDA		Human	PMID:19490146
Cellular Component	GO:0030425	dendrite	Plk3	IDA		Rat	PMID:10523297|RGD:61555
Cellular Component	GO:0005795	Golgi stack	PLK3	IDA		Human	PMID:14980500
Cellular Component	GO:0043025	neuronal cell body	Plk3	IDA		Rat	PMID:10523297|RGD:61555
Cellular Component	GO:0005730	nucleolus	PLK3	IDA		Human	PMID:17264206
Cellular Component	GO:0005634	nucleus	PLK3	IDA		Human	PMID:19490146
Cellular Component	GO:0005634	nucleus	PLK3	IDA		Human	PMID:21098032
Biological Process	GO:0031122	cytoplasmic microtubule organization	PLK3	IMP		Human	PMID:20951827
Biological Process	GO:0006974	DNA damage response	PLK3	IMP		Human	PMID:16481012
Biological Process	GO:0006974	DNA damage response	PLK3	IDA		Human	PMID:19490146
Biological Process	GO:0006974	DNA damage response	Plk3	IMP		Mouse	MGI:MGI:5142362|PMID:21376736
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	PLK3	IMP		Human	PMID:17264206
Biological Process	GO:0090166	Golgi disassembly	PLK3	IDA		Human	PMID:14980500
Biological Process	GO:0090166	Golgi disassembly	PLK3	IDA		Human	PMID:19103756
Biological Process	GO:0044819	mitotic G1/S transition checkpoint signaling	Plk3	IMP		Mouse	MGI:MGI:5142362|PMID:21376736
Biological Process	GO:0043066	negative regulation of apoptotic process	PLK3	IDA		Human	PMID:19490146
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	PLK3	IDA		Human	PMID:19490146
Biological Process	GO:1904716	positive regulation of chaperone-mediated autophagy	PLK3	IDA		Human	PMID:27344333
Biological Process	GO:0090316	positive regulation of intracellular protein transport	PLK3	IMP		Human	PMID:20951827
Biological Process	GO:2000777	positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia	PLK3	IDA		Human	PMID:20889502
Biological Process	GO:0043491	protein kinase B signaling	Plk3	IMP		Mouse	MGI:MGI:5298335|PMID:20940307
Biological Process	GO:0006468	protein phosphorylation	Plk3	IDA		Mouse	MGI:MGI:5298335|PMID:20940307
Biological Process	GO:0051302	regulation of cell division	PLK3	IDA		Human	PMID:20951827
Biological Process	GO:0032465	regulation of cytokinesis	PLK3	IMP		Human	PMID:16478733
Biological Process	GO:0006970	response to osmotic stress	PLK3	IDA		Human	PMID:21098032
Biological Process	GO:0009314	response to radiation	PLK3	IDA		Human	PMID:21376736
Biological Process	GO:0000302	response to reactive oxygen species	PLK3	IDA		Human	PMID:11447225

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern