Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLK4
  • Mouse genes Plk4
  • Rat genes Plk4
  • Zfish genes plk4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plk4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	PLK4	IPI	UniProtKB:O00444	Human	PMID:16189514
Molecular Function	GO:0042802	identical protein binding	PLK4	IPI	UniProtKB:O00444	Human	PMID:24997597
Molecular Function	GO:0042802	identical protein binding	PLK4	IPI	UniProtKB:O00444	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	PLK4	IPI	UniProtKB:O00444	Human	PMID:27107012
Molecular Function	GO:0042802	identical protein binding	Plk4	IPI	UniProtKB:Q64702	Mouse	MGI:MGI:3697276|PMID:17174311
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:P31947	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q9H8V3	Human	PMID:20348415
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:O94986	Human	PMID:20852615
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:O94986-3	Human	PMID:20852615
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:O94986	Human	PMID:21059844
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:O94986-3	Human	PMID:21059844
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q969U6	Human	PMID:21725316
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:O94986	Human	PMID:24997597
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:O94986-3	Human	PMID:24997597
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q8TEP8	Human	PMID:24997597
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q8TEP8-3	Human	PMID:24997597
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:P36575	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q14241	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q9NX04	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q9Y297	Human	PMID:25503564
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:O94986	Human	PMID:26188084
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q15468	Human	PMID:26188084
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q8TEP8	Human	PMID:26188084
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:O94986	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:O94986	Human	PMID:26638075
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q9Y297	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q92830	Human	PMID:27796307
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q92831	Human	PMID:27796307
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:O15060	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:O95995	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:P59910	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q14241	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q96A09	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q96R06	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q9BYV2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q9H4L5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q9UBB9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:Q5VWP2,UniProtKB:Q8TEP8	Human	PMID:32433990
Molecular Function	GO:0005515	protein binding	PLK4	IPI	UniProtKB:P07237	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Plk4	IPI	UniProtKB:Q64279	Mouse	MGI:MGI:4359361|PMID:17891141
Molecular Function	GO:0005515	protein binding	Plk4	IPI	UniProtKB:P02686-1|UniProtKB:P03772|UniProtKB:Q8WWL7	Mouse	MGI:MGI:3697276|PMID:17174311
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK4	IDA		Human	PMID:21725316
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PLK4	IDA		Human	PMID:27796307
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Plk4	IDA		Mouse	MGI:MGI:4359361|PMID:17891141
Cellular Component	GO:0005814	centriole	PLK4	IDA		Human	PMID:16244668
Cellular Component	GO:0005814	centriole	PLK4	IDA		Human	PMID:17681131
Cellular Component	GO:0005814	centriole	PLK4	IDA		Human	PMID:22020124
Cellular Component	GO:0005814	centriole	PLK4	IDA		Human	PMID:27796307
Cellular Component	GO:0005813	centrosome	PLK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	PLK4	IDA		Human	PMID:21399614
Cellular Component	GO:0005813	centrosome	PLK4	IDA		Human	PMID:30804208
Cellular Component	GO:0005813	centrosome	PLK4	IDA		Human	PMID:32433990
Cellular Component	GO:0005829	cytosol	PLK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098536	deuterosome	Plk4	IDA		Mouse	MGI:MGI:5527201|PMID:24240477
Cellular Component	GO:0005730	nucleolus	Plk4	IDA		Mouse	MGI:MGI:4359361|PMID:17891141
Cellular Component	GO:0120098	procentriole	PLK4	IDA		Human	PMID:24997597
Cellular Component	GO:0120099	procentriole replication complex	PLK4	IPI		Human	PMID:24997597
Cellular Component	GO:0001741	XY body	Plk4	IDA		Mouse	PMID:22854038
Biological Process	GO:0098534	centriole assembly	plk4	IMP	ZFIN:ZDB-MRPHLNO-170410-1,ZFIN:ZDB-MRPHLNO-170410-2	Zfish	PMID:25344692
Biological Process	GO:0007099	centriole replication	PLK4	IDA		Human	PMID:21059844
Biological Process	GO:0007099	centriole replication	PLK4	IMP		Human	PMID:21725316
Biological Process	GO:0007099	centriole replication	PLK4	IMP		Human	PMID:22020124
Biological Process	GO:0007099	centriole replication	PLK4	IMP		Human	PMID:30804208
Biological Process	GO:0007099	centriole replication	Plk4	IMP		Mouse	MGI:MGI:5527201|PMID:24240477
Biological Process	GO:0060271	cilium assembly	PLK4	IMP		Human	PMID:30804208
Biological Process	GO:0060271	cilium assembly	plk4	IMP	ZFIN:ZDB-MRPHLNO-170410-1,ZFIN:ZDB-MRPHLNO-170410-2	Zfish	PMID:25344692
Biological Process	GO:0098535	de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	Plk4	IMP		Mouse	MGI:MGI:5527201|PMID:24240477
Biological Process	GO:0048589	developmental growth	plk4	IMP	ZFIN:ZDB-MRPHLNO-170410-1,ZFIN:ZDB-MRPHLNO-170410-2	Zfish	PMID:25344692
Biological Process	GO:0046601	positive regulation of centriole replication	PLK4	IDA		Human	PMID:22349705
Biological Process	GO:0046601	positive regulation of centriole replication	PLK4	IMP		Human	PMID:16244668
Biological Process	GO:0046601	positive regulation of centriole replication	PLK4	IMP		Human	PMID:17681131
Biological Process	GO:0046601	positive regulation of centriole replication	PLK4	IDA		Human	PMID:27796307
Biological Process	GO:0006468	protein phosphorylation	PLK4	IDA		Human	PMID:27796307
Biological Process	GO:0006468	protein phosphorylation	PLK4	IDA		Human	PMID:30804208
Biological Process	GO:0060707	trophoblast giant cell differentiation	Plk4	IMP		Mouse	MGI:MGI:4359361|PMID:17891141

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern