Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLN
  • Mouse genes Pln
  • Rat genes Pln
  • Zfish genes pln
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pln

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042030	ATPase inhibitor activity	PLN	IDA		Human	PMID:19708671
Molecular Function	GO:0042030	ATPase inhibitor activity	Pln	IDA		Rat	PMID:12403631|RGD:633528
Molecular Function	GO:0042802	identical protein binding	Pln	IPI	RGD:619894	Rat	PMID:23458196|RGD:7327178
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q09013	Human	PMID:15598648
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q5T700	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q92838	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q92838	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:O43889-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q92838	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q96BA8	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9BXK5	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:P16615	Human	PMID:28890335
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q96GC9	Human	PMID:28890335
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q92838	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:A0A0S2Z4U3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:O14880	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:O15342	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:O15393-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:O60883	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:O95197-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:O95436-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:O95471	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:P07307-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:P15941-11	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:P19397	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:P31937	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:P32856-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:P43628	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:P48165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q13323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q14318	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q15849	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q16623	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q4KMG9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q5T700	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q6N075	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q6UW68	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q7Z7G2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q7Z7N9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q8IWU4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q8N112	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q8N661	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q8TBE3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q8TBJ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q8TED1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q92838	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q96B21	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q99735	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9BVX2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9BXK5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9GZR5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9GZW8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9GZY8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9H2K0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9HBV2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9NP94	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9NPE6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9NQQ7-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9NR31	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9NWC5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9UHP7-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLN	IPI	UniProtKB:Q9Y3P8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pln	IPI	UniProtKB:Q8R429	Mouse	MGI:MGI:6304509|PMID:30299255
Molecular Function	GO:0005515	protein binding	Pln	IPI	UniProtKB:Q9ESG8	Mouse	MGI:MGI:5706675|PMID:26644582
Molecular Function	GO:0005515	protein binding	Pln	IPI	UniProtKB:P05132|UniProtKB:P61981|UniProtKB:Q13557	Mouse	MGI:MGI:6467713|PMID:32873725
Molecular Function	GO:0005515	protein binding	Pln	IPI	PR:O55143-1	Mouse	PMID:27923914
Molecular Function	GO:0005515	protein binding	Pln	IPI	PR:O55143	Mouse	PMID:15201433
Molecular Function	GO:0005515	protein binding	Pln	IPI	RGD:1303071	Rat	PMID:17901878|RGD:2312630
Molecular Function	GO:0005515	protein binding	Pln	IPI	UniProtKB:Q6JP77	Rat	PMID:17901878|RGD:2312630
Molecular Function	GO:0042803	protein homodimerization activity	Pln	IDA		Mouse	MGI:MGI:6304509|PMID:30299255
Cellular Component	GO:0090534	calcium ion-transporting ATPase complex	PLN	IDA		Human	PMID:19708671
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Pln	IDA		Mouse	MGI:MGI:6281843|PMID:30733280
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Pln	IDA		Mouse	PMID:27923914
Cellular Component	GO:0016020	membrane	PLN	IDA		Human	PMID:19708671
Cellular Component	GO:0005739	mitochondrion	PLN	HDA		Human	PMID:20833797
Cellular Component	GO:0032991	protein-containing complex	Pln	IDA		Rat	PMID:17901878|RGD:2312630
Cellular Component	GO:0016529	sarcoplasmic reticulum	Pln	IDA		Mouse	PMID:9038922
Cellular Component	GO:0016529	sarcoplasmic reticulum	Pln	IDA		Rat	PMID:12403631|RGD:633528
Cellular Component	GO:0016529	sarcoplasmic reticulum	Pln	IDA		Rat	PMID:17901878|RGD:2312630
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Pln	IDA		Mouse	MGI:MGI:5751610|PMID:26816378
Cellular Component	GO:0031982	vesicle	Pln	IDA		Rat	PMID:12403631|RGD:633528
Biological Process	GO:0001675	acrosome assembly	Pln	IDA		Mouse	MGI:MGI:6281843|PMID:30733280
Biological Process	GO:0086023	adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	Pln	IMP	MGI:MGI:2158357	Mouse	PMID:10471356
Biological Process	GO:0006816	calcium ion transport	Pln	IMP		Rat	PMID:12403631|RGD:633528
Biological Process	GO:0048738	cardiac muscle tissue development	Pln	IGI	MGI:MGI:1330824	Mouse	PMID:10555147
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Pln	IDA		Mouse	MGI:MGI:6281843|PMID:30733280
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Pln	IGI	MGI:MGI:88110	Mouse	PMID:10555147
Biological Process	GO:0046716	muscle cell cellular homeostasis	Pln	IGI	MGI:MGI:88110	Mouse	PMID:10555147
Biological Process	GO:0032780	negative regulation of ATP-dependent activity	PLN	IDA		Human	PMID:19708671
Biological Process	GO:1901895	negative regulation of ATPase-coupled calcium transmembrane transporter activity	PLN	IDA		Human	PMID:19708671
Biological Process	GO:1901895	negative regulation of ATPase-coupled calcium transmembrane transporter activity	PLN	IDA		Human	PMID:28890335
Biological Process	GO:1901895	negative regulation of ATPase-coupled calcium transmembrane transporter activity	Pln	IMP		Mouse	MGI:MGI:6304509|PMID:30299255
Biological Process	GO:1901895	negative regulation of ATPase-coupled calcium transmembrane transporter activity	Pln	IDA		Mouse	PMID:27923914
Biological Process	GO:1901877	negative regulation of calcium ion binding	PLN	IDA		Human	PMID:19708671
Biological Process	GO:1901877	negative regulation of calcium ion binding	Pln	IDA		Mouse	PMID:27923914
Biological Process	GO:1902081	negative regulation of calcium ion import into sarcoplasmic reticulum	Pln	IMP		Mouse	MGI:MGI:6304509|PMID:30299255
Biological Process	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	PLN	IDA		Human	PMID:19708671
Biological Process	GO:0051926	negative regulation of calcium ion transport	PLN	IDA		Human	PMID:19708671
Biological Process	GO:0045822	negative regulation of heart contraction	Pln	IMP	MGI:MGI:2158357	Mouse	PMID:8062415
Biological Process	GO:0045822	negative regulation of heart contraction	Pln	IGI	MGI:MGI:88110	Mouse	PMID:10555147
Biological Process	GO:0010459	negative regulation of heart rate	PLN	IMP		Human	PMID:16432188
Biological Process	GO:0007219	Notch signaling pathway	Pln	IDA		Mouse	PMID:23117660
Biological Process	GO:1901894	regulation of ATPase-coupled calcium transmembrane transporter activity	PLN	IDA		Human	PMID:22427649
Biological Process	GO:0090279	regulation of calcium ion import	Pln	IMP	MGI:MGI:2158357	Mouse	PMID:8620604
Biological Process	GO:0051924	regulation of calcium ion transport	PLN	IDA		Human	PMID:22427649
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Pln	IMP	MGI:MGI:2158357	Mouse	PMID:8620604
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Pln	IMP	MGI:MGI:2158357	Mouse	PMID:8831698
Biological Process	GO:0008016	regulation of heart contraction	PLN	IMP		Human	PMID:16432188
Biological Process	GO:0008016	regulation of heart contraction	Pln	IMP	MGI:MGI:2158357	Mouse	PMID:8831698
Biological Process	GO:1901077	regulation of relaxation of muscle	Pln	IMP	MGI:MGI:2158357	Mouse	PMID:10024311
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Pln	IMP	MGI:MGI:2158357	Mouse	PMID:9118481
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	Pln	IMP	MGI:MGI:2158357	Mouse	PMID:10603936
Biological Process	GO:0002026	regulation of the force of heart contraction	Pln	IGI	MGI:MGI:88110	Mouse	PMID:10555147
Biological Process	GO:0002026	regulation of the force of heart contraction	Pln	IGI	MGI:MGI:1330824	Mouse	PMID:10555147
Biological Process	GO:0002026	regulation of the force of heart contraction	Pln	IMP	MGI:MGI:2158357	Mouse	PMID:9118481
Biological Process	GO:0086092	regulation of the force of heart contraction by cardiac conduction	Pln	IMP	MGI:MGI:2158357	Mouse	PMID:10644605
Biological Process	GO:0032868	response to insulin	Pln	IEP		Rat	PMID:22185592|RGD:7327207
Biological Process	GO:0033574	response to testosterone	Pln	IDA		Rat	PMID:23203968|RGD:7327180
Biological Process	GO:0010043	response to zinc ion	Pln	IDA		Rat	PMID:23812383|RGD:7327175

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern