Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLP1
  • Mouse genes Plp1
  • Rat genes Plp1
  • Zfish genes plp1a,plp1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PLP1	IPI	UniProtKB:Q16849-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLP1	IPI	UniProtKB:Q96BA8	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	PLP1	IPI	UniProtKB:Q9BXK5	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	PLP1	IPI	UniProtKB:P05067-4	Human	PMID:26960425
Molecular Function	GO:0005515	protein binding	Plp1	IPI	PR:Q9DBB1	Mouse	PMID:15284227
Molecular Function	GO:0044877	protein-containing complex binding	Plp1	IPI	RGD:61862,RGD:61863,RGD:1310613	Rat	PMID:16510724|RGD:30296668
Molecular Function	GO:0019911	structural constituent of myelin sheath	Plp1	IMP		Rat	PMID:3476944|RGD:1358780
Cellular Component	GO:0034683	integrin alphav-beta3 complex	Plp1	IDA		Rat	PMID:16510724|RGD:30296668
Cellular Component	GO:0043209	myelin sheath	Plp1	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0043209	myelin sheath	Plp1	IDA		Mouse	PMID:20578039
Cellular Component	GO:0043209	myelin sheath	Plp1	IDA		Mouse	PMID:1694232
Cellular Component	GO:0043209	myelin sheath	Plp1	IDA		Rat	PMID:17960831|RGD:10047364
Cellular Component	GO:0005886	plasma membrane	PLP1	IDA		Human	PMID:24103481
Biological Process	GO:0098990	AMPA selective glutamate receptor signaling pathway	Plp1	IMP		Rat	PMID:16510724|RGD:30296668
Biological Process	GO:0014002	astrocyte development	Plp1	IGI	MGI:MGI:1917997	Mouse	PMID:24038504
Biological Process	GO:0061564	axon development	Plp1	IGI	MGI:MGI:1917997	Mouse	PMID:24038504
Biological Process	GO:0008366	axon ensheathment	Plp1	IMP	MGI:MGI:1856065	Mouse	PMID:14169723
Biological Process	GO:0022010	central nervous system myelination	Plp1	IMP	MGI:MGI:1856067	Mouse	PMID:1694232
Biological Process	GO:0010001	glial cell differentiation	Plp1	IMP		Rat	PMID:1384273|RGD:1358779
Biological Process	GO:0010001	glial cell differentiation	Plp1	IMP		Rat	PMID:7674382|RGD:1358778
Biological Process	GO:0006954	inflammatory response	Plp1	IGI	MGI:MGI:1917997	Mouse	PMID:24038504
Biological Process	GO:0042759	long-chain fatty acid biosynthetic process	Plp1	IMP	MGI:MGI:1856065	Mouse	PMID:1150661
Biological Process	GO:0042552	myelination	Plp1	IGI	MGI:MGI:1917997	Mouse	PMID:24038504
Biological Process	GO:0042552	myelination	Plp1	IMP		Mouse	PMID:1373175
Biological Process	GO:0042552	myelination	Plp1	IMP		Mouse	PMID:28251676
Biological Process	GO:0042552	myelination	Plp1	IMP	MGI:MGI:1856065	Mouse	PMID:1150661
Biological Process	GO:0042552	myelination	Plp1	IMP		Rat	PMID:3476944|RGD:1358780
Biological Process	GO:0042552	myelination	plp1a	IEP		Zfish	PMID:12112375
Biological Process	GO:1904427	positive regulation of calcium ion transmembrane transport	Plp1	IMP		Rat	PMID:16510724|RGD:30296668
Biological Process	GO:0030335	positive regulation of cell migration	Plp1	IMP		Rat	PMID:16510724|RGD:30296668
Biological Process	GO:0010628	positive regulation of gene expression	Plp1	IMP		Mouse	MGI:MGI:3834050|PMID:17634366
Biological Process	GO:0010628	positive regulation of gene expression	Plp1	IMP		Mouse	PMID:1373175
Biological Process	GO:0021762	substantia nigra development	PLP1	HEP		Human	PMID:22926577

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern