Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLSCR1,PLSCR2
  • Mouse genes Plscr2
  • Rat genes Plscr1
  • Zfish genes plscr3b,si:ch211-71m22.1,si:ch211-71m22.5,si:ch73-206p6.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plscr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	PLSCR1	IDA		Human	PMID:18629440
Molecular Function	GO:0005509	calcium ion binding	PLSCR1	IDA		Human	PMID:23590222
Molecular Function	GO:0005509	calcium ion binding	PLSCR1	IDA		Human	PMID:23659204
Molecular Function	GO:0005509	calcium ion binding	PLSCR1	IDA		Human	PMID:24343571
Molecular Function	GO:0005509	calcium ion binding	PLSCR1	IDA		Human	PMID:8663431
Molecular Function	GO:0042609	CD4 receptor binding	PLSCR1	IPI	UniProtKB:P01730	Human	PMID:19333378
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PLSCR1	IDA		Human	PMID:16091359
Molecular Function	GO:0019899	enzyme binding	PLSCR1	IPI	UniProtKB:P56817	Human	PMID:12586838
Molecular Function	GO:0019899	enzyme binding	PLSCR1	IPI	UniProtKB:P11388	Human	PMID:17567603
Molecular Function	GO:0019899	enzyme binding	PLSCR1	IPI	UniProtKB:Q02880	Human	PMID:17567603
Molecular Function	GO:0019899	enzyme binding	PLSCR1	IPI	UniProtKB:P24158	Human	PMID:17712045
Molecular Function	GO:0019899	enzyme binding	Plscr1	IPI	UniProtKB:Q07014	Rat	PMID:18579528|RGD:2303650
Molecular Function	GO:0019899	enzyme binding	Plscr1	IPI	UniProtKB:Q64725	Rat	PMID:18579528|RGD:2303650
Molecular Function	GO:0005154	epidermal growth factor receptor binding	PLSCR1	IPI	UniProtKB:P00533	Human	PMID:12009895
Molecular Function	GO:0032791	lead ion binding	PLSCR1	IDA		Human	PMID:23659204
Molecular Function	GO:0000287	magnesium ion binding	PLSCR1	IDA		Human	PMID:27206388
Molecular Function	GO:0045340	mercury ion binding	PLSCR1	IDA		Human	PMID:23659204
Molecular Function	GO:0004518	nuclease activity	PLSCR1	IMP		Human	PMID:27206388
Molecular Function	GO:0017128	phospholipid scramblase activity	PLSCR1	IDA		Human	PMID:10770950
Molecular Function	GO:0017128	phospholipid scramblase activity	PLSCR1	IDA		Human	PMID:18629440
Molecular Function	GO:0017128	phospholipid scramblase activity	PLSCR1	IDA		Human	PMID:23590222
Molecular Function	GO:0017128	phospholipid scramblase activity	PLSCR1	IDA		Human	PMID:23659204
Molecular Function	GO:0017128	phospholipid scramblase activity	PLSCR1	IDA		Human	PMID:24343571
Molecular Function	GO:0017128	phospholipid scramblase activity	PLSCR1	IDA		Human	PMID:29748552
Molecular Function	GO:0017128	phospholipid scramblase activity	PLSCR1	IDA		Human	PMID:8663431
Molecular Function	GO:0017128	phospholipid scramblase activity	PLSCR1	IDA		Human	PMID:9218461
Molecular Function	GO:0017128	phospholipid scramblase activity	PLSCR1	IDA		Human	PMID:9572851
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:O76003	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q01844	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q15038	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q16630	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q8WWR8	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q92734	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9NXX0	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:P03973	Human	PMID:19333378
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q16610	Human	PMID:20870722
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q7Z417	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q16625	Human	PMID:21806988
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9WMX2	Human	PMID:21806988
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:P61417	Human	PMID:21911467
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:P69974	Human	PMID:21911467
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q56973	Human	PMID:21911467
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q8ZG77	Human	PMID:21911467
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q8IUW5	Human	PMID:22052202
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q8NC24	Human	PMID:22052202
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q969Z4	Human	PMID:22052202
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:P09022	Human	PMID:23088713
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q92731	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q92731-3	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:A5D8V6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:A8KA13	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:O43559	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:O75716	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:O76003	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:P49796	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:P60412	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q01844	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q13563	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q15038	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q15077	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q5TA78	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q5TA82	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q6DKI2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q6L8G9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q6RVD6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q8IWZ5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q8NEC5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q8TAU3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q92608	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q92731	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q92922	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q96SQ5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9BWG6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9BYQ4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9BYQ6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9BYR5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9H2X0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9H4E7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9HBR3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9NQL9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9NXX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9NZ81	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9UBR2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q92731-3	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:A0A0S2Z5X4	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9BWG6	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:Q9UL62	Human	PMID:32110987
Molecular Function	GO:0005515	protein binding	PLSCR1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:A6H8Z2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:O75208	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:P29972	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:P32242	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:Q12837	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:Q5T5B0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:Q5T7P2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:Q5TA76	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:Q5TCM9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:Q8N2G4-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:Q8WZ55	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLSCR2	IPI	UniProtKB:Q9P2W3	Human	PMID:32296183
Molecular Function	GO:0017124	SH3 domain binding	PLSCR1	IDA		Human	PMID:11390389
Molecular Function	GO:0001618	virus receptor activity	PLSCR1	IMP		Human	PMID:21806988
Molecular Function	GO:0008270	zinc ion binding	PLSCR1	IDA		Human	PMID:27206388
Cellular Component	GO:0062023	collagen-containing extracellular matrix	PLSCR1	IDA		Human	PMID:20870722
Cellular Component	GO:0005737	cytoplasm	PLSCR1	IDA		Human	PMID:22052202
Cellular Component	GO:0005737	cytoplasm	Plscr2	IDA		Mouse	MGI:MGI:5284813|PMID:12509439
Cellular Component	GO:0005737	cytoplasm	si:ch211-71m22.1	IDA		Zfish	PMID:25139857
Cellular Component	GO:0005829	cytosol	PLSCR1	IDA		Human	PMID:17712045
Cellular Component	GO:0005783	endoplasmic reticulum	PLSCR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	PLSCR1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	PLSCR1	HDA		Human	PMID:23533145
Cellular Component	GO:0005794	Golgi apparatus	PLSCR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	PLSCR1	IDA		Human	PMID:12586838
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PLSCR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	PLSCR1	HDA		Human	PMID:19946888
Cellular Component	GO:0045121	membrane raft	PLSCR1	IDA		Human	PMID:12009895
Cellular Component	GO:0045121	membrane raft	Plscr1	IDA		Rat	PMID:18579528|RGD:2303650
Cellular Component	GO:0005730	nucleolus	PLSCR1	IDA		Human	PMID:17567603
Cellular Component	GO:0005730	nucleolus	PLSCR1	IDA		Human	PMID:24356419
Cellular Component	GO:0005654	nucleoplasm	PLSCR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PLSCR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PLSCR1	IDA		Human	PMID:12564925
Cellular Component	GO:0005634	nucleus	PLSCR1	IDA		Human	PMID:20870722
Cellular Component	GO:0005634	nucleus	Plscr2	IDA		Mouse	MGI:MGI:5284813|PMID:12509439
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PLSCR1	IDA		Human	PMID:22052202
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PLSCR1	IDA		Human	PMID:26745724
Cellular Component	GO:0005886	plasma membrane	PLSCR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PLSCR1	IDA		Human	PMID:12564925
Cellular Component	GO:0005886	plasma membrane	PLSCR1	IDA		Human	PMID:12586838
Cellular Component	GO:0005886	plasma membrane	PLSCR1	IDA		Human	PMID:17712045
Cellular Component	GO:0005886	plasma membrane	PLSCR1	IDA		Human	PMID:19333378
Cellular Component	GO:0005886	plasma membrane	PLSCR1	IDA		Human	PMID:20870722
Cellular Component	GO:0005886	plasma membrane	PLSCR1	IDA		Human	PMID:22052202
Cellular Component	GO:0005886	plasma membrane	PLSCR1	IDA		Human	PMID:23590222
Cellular Component	GO:0005886	plasma membrane	PLSCR1	IDA		Human	PMID:26745724
Cellular Component	GO:0005886	plasma membrane	PLSCR1	IDA		Human	PMID:9218461
Cellular Component	GO:0005886	plasma membrane	Plscr1	IDA		Rat	PMID:17712045|RGD:8553758
Cellular Component	GO:0005886	plasma membrane	Plscr1	IDA		Rat	PMID:18579528|RGD:2303650
Biological Process	GO:0006915	apoptotic process	PLSCR1	IDA		Human	PMID:10770950
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Plscr2	IEP		Mouse	MGI:MGI:3762685|PMID:17590392
Biological Process	GO:0060271	cilium assembly	si:ch211-71m22.1	IMP	ZFIN:ZDB-MRPHLNO-150910-4	Zfish	PMID:25139857
Biological Process	GO:0044782	cilium organization	si:ch211-71m22.1	IMP	ZFIN:ZDB-MRPHLNO-150910-4	Zfish	PMID:25139857
Biological Process	GO:0051607	defense response to virus	PLSCR1	IMP		Human	PMID:15308695
Biological Process	GO:0006955	immune response	Plscr1	IMP		Rat	PMID:11259432|RGD:727313
Biological Process	GO:0050765	negative regulation of phagocytosis	PLSCR1	IMP		Human	PMID:26745724
Biological Process	GO:0045071	negative regulation of viral genome replication	PLSCR1	IMP		Human	PMID:15308695
Biological Process	GO:0070782	phosphatidylserine exposure on apoptotic cell surface	PLSCR1	IMP		Human	PMID:32110987
Biological Process	GO:0017121	plasma membrane phospholipid scrambling	PLSCR1	IDA		Human	PMID:10770950
Biological Process	GO:0017121	plasma membrane phospholipid scrambling	PLSCR1	IDA		Human	PMID:18629440
Biological Process	GO:0017121	plasma membrane phospholipid scrambling	PLSCR1	IDA		Human	PMID:9218461
Biological Process	GO:0017121	plasma membrane phospholipid scrambling	Plscr1	IMP		Rat	PMID:17712045|RGD:8553758
Biological Process	GO:1905820	positive regulation of chromosome separation	PLSCR1	IDA		Human	PMID:27206388
Biological Process	GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	PLSCR1	IDA		Human	PMID:17567603
Biological Process	GO:0010628	positive regulation of gene expression	PLSCR1	IMP		Human	PMID:15308695
Biological Process	GO:0045089	positive regulation of innate immune response	PLSCR1	IMP		Human	PMID:15308695
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PLSCR1	IDA		Human	PMID:16091359
Biological Process	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	Plscr1	IMP		Rat	PMID:18579528|RGD:2303650
Biological Process	GO:0033003	regulation of mast cell activation	Plscr1	IMP		Rat	PMID:18579528|RGD:2303650
Biological Process	GO:0035456	response to interferon-beta	PLSCR1	IMP		Human	PMID:15308695
Biological Process	GO:0010288	response to lead ion	PLSCR1	IDA		Human	PMID:29748552

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern