Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PMAIP1
  • Mouse genes Pmaip1
  • Rat genes Pmaip1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pmaip1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PMAIP1	IPI	UniProtKB:Q07812	Human	PMID:15705586
Molecular Function	GO:0005515	protein binding	PMAIP1	IPI	UniProtKB:Q07820	Human	PMID:15901672
Molecular Function	GO:0005515	protein binding	PMAIP1	IPI	UniProtKB:Q07820	Human	PMID:20085765
Molecular Function	GO:0005515	protein binding	PMAIP1	IPI	UniProtKB:Q07820	Human	PMID:21132008
Molecular Function	GO:0005515	protein binding	PMAIP1	IPI	UniProtKB:Q07820-1	Human	PMID:21145489
Molecular Function	GO:0005515	protein binding	PMAIP1	IPI	UniProtKB:P10415	Human	PMID:21454712
Molecular Function	GO:0005515	protein binding	PMAIP1	IPI	UniProtKB:P10415-1	Human	PMID:21454712
Molecular Function	GO:0005515	protein binding	PMAIP1	IPI	UniProtKB:Q07820	Human	PMID:21454712
Molecular Function	GO:0005515	protein binding	PMAIP1	IPI	UniProtKB:Q9HD36	Human	PMID:23563182
Molecular Function	GO:0005515	protein binding	Pmaip1	IPI	UniProtKB:Q07820	Mouse	MGI:MGI:3694305|PMID:16697956
Molecular Function	GO:0005515	protein binding	Pmaip1	IPI	UniProtKB:P97287	Mouse	MGI:MGI:6093095|PMID:17389404
Molecular Function	GO:0005515	protein binding	Pmaip1	IPI	UniProtKB:P97287	Mouse	MGI:MGI:3689775|PMID:15694340
Molecular Function	GO:0005515	protein binding	Pmaip1	IPI	UniProtKB:P97287	Mouse	MGI:MGI:4822083|PMID:20627101
Molecular Function	GO:0005515	protein binding	Pmaip1	IPI	UniProtKB:P97287	Mouse	MGI:MGI:4939122|PMID:18589438
Cellular Component	GO:0097136	Bcl-2 family protein complex	PMAIP1	IPI		Human	PMID:21132008
Cellular Component	GO:0005829	cytosol	PMAIP1	IDA		Human	PMID:15705586
Cellular Component	GO:0005829	cytosol	PMAIP1	IDA		Human	PMID:21145489
Cellular Component	GO:0005739	mitochondrion	PMAIP1	IDA		Human	PMID:14500711
Cellular Component	GO:0005739	mitochondrion	PMAIP1	IDA		Human	PMID:15102863
Cellular Component	GO:0005739	mitochondrion	PMAIP1	IDA		Human	PMID:15705586
Cellular Component	GO:0005739	mitochondrion	PMAIP1	IDA		Human	PMID:21145489
Cellular Component	GO:0005739	mitochondrion	Pmaip1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Pmaip1	IDA		Mouse	PMID:10807576
Cellular Component	GO:0005739	mitochondrion	Pmaip1	IDA		Rat	PMID:17127418|RGD:2314141
Cellular Component	GO:0005634	nucleus	PMAIP1	IDA		Human	PMID:12879012
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Pmaip1	IDA		Mouse	MGI:MGI:5009174|PMID:14699081
Biological Process	GO:0006915	apoptotic process	PMAIP1	IMP		Human	PMID:17599062
Biological Process	GO:0006915	apoptotic process	Pmaip1	IEP		Rat	PMID:18959742|RGD:2314140
Biological Process	GO:0042149	cellular response to glucose starvation	PMAIP1	IMP		Human	PMID:21145489
Biological Process	GO:0071456	cellular response to hypoxia	PMAIP1	IEP		Human	PMID:14699081
Biological Process	GO:0071456	cellular response to hypoxia	PMAIP1	IEP		Human	PMID:20810912
Biological Process	GO:0051607	defense response to virus	PMAIP1	IDA		Human	PMID:15705586
Biological Process	GO:0006974	DNA damage response	Pmaip1	IMP	MGI:MGI:2678372	Mouse	PMID:12952892
Biological Process	GO:0044346	fibroblast apoptotic process	Pmaip1	IMP	MGI:MGI:2681649	Mouse	PMID:14500851
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	PMAIP1	IDA		Human	PMID:14500711
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	PMAIP1	IMP		Human	PMID:15102863
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	Pmaip1	IMP		Mouse	MGI:MGI:2679929|PMID:14500851
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Pmaip1	IMP	MGI:MGI:2678372	Mouse	PMID:12952892
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Pmaip1	IDA		Mouse	PMID:10807576
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Pmaip1	IMP		Mouse	MGI:MGI:5621265|PMID:16407291
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Pmaip1	IMP	MGI:MGI:2678372	Mouse	PMID:12952892
Biological Process	GO:0010917	negative regulation of mitochondrial membrane potential	Pmaip1	IDA		Mouse	MGI:MGI:5009174|PMID:14699081
Biological Process	GO:0043065	positive regulation of apoptotic process	PMAIP1	IMP		Human	PMID:17289999
Biological Process	GO:0043065	positive regulation of apoptotic process	PMAIP1	IDA		Human	PMID:21132008
Biological Process	GO:0043065	positive regulation of apoptotic process	PMAIP1	IDA		Human	PMID:21145489
Biological Process	GO:0043065	positive regulation of apoptotic process	PMAIP1	IMP		Human	PMID:21525171
Biological Process	GO:0043065	positive regulation of apoptotic process	Pmaip1	IMP		Rat	PMID:18614532|RGD:5128588
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMAIP1	IDA		Human	PMID:14699081
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	PMAIP1	IMP		Human	PMID:15102863
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	Pmaip1	IMP		Mouse	MGI:MGI:2679929|PMID:14500851
Biological Process	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMAIP1	IDA		Human	PMID:15705586
Biological Process	GO:2000271	positive regulation of fibroblast apoptotic process	Pmaip1	IMP	MGI:MGI:2681649	Mouse	PMID:14500851
Biological Process	GO:0010907	positive regulation of glucose metabolic process	PMAIP1	IDA		Human	PMID:21145489
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	PMAIP1	IDA		Human	PMID:21454712
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Pmaip1	IMP	MGI:MGI:2678372	Mouse	PMID:15703398
Biological Process	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Pmaip1	IMP	MGI:MGI:2678372	Mouse	PMID:12952892
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMAIP1	IDA		Human	PMID:14500711
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMAIP1	IDA		Human	PMID:14699081
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMAIP1	IDA		Human	PMID:15705586
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMAIP1	IMP		Human	PMID:15705586
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMAIP1	IMP		Human	PMID:17289999
Biological Process	GO:0010498	proteasomal protein catabolic process	PMAIP1	IDA		Human	PMID:15901672
Biological Process	GO:0072593	reactive oxygen species metabolic process	PMAIP1	IDA		Human	PMID:14699081
Biological Process	GO:0046902	regulation of mitochondrial membrane permeability	PMAIP1	IDA		Human	PMID:14500711
Biological Process	GO:0001836	release of cytochrome c from mitochondria	Pmaip1	IDA		Mouse	MGI:MGI:5009174|PMID:14699081
Biological Process	GO:0001836	release of cytochrome c from mitochondria	Pmaip1	IMP	MGI:MGI:2678372	Mouse	PMID:12952892
Biological Process	GO:0043331	response to dsRNA	PMAIP1	IDA		Human	PMID:15705586
Biological Process	GO:0009411	response to UV	Pmaip1	IMP	MGI:MGI:2678372	Mouse	PMID:12952892
Biological Process	GO:0010165	response to X-ray	Pmaip1	IMP	MGI:MGI:2678372	Mouse	PMID:12952892
Biological Process	GO:0043029	T cell homeostasis	Pmaip1	IMP		Mouse	MGI:MGI:3795821|PMID:18411339

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern