Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PMEL
  • Mouse genes Pmel
  • Rat genes Pmel
  • Zfish genes pmela,pmelb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pmel

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	PMEL	IPI	UniProtKB:P40967	Human	PMID:19666488
Molecular Function	GO:0005515	protein binding	PMEL	IPI	UniProtKB:Q16655	Human	PMID:15695812
Molecular Function	GO:0005515	protein binding	PMEL	IPI	UniProtKB:O52302	Human	PMID:20374249
Molecular Function	GO:0005515	protein binding	PMEL	IPI	UniProtKB:P02649	Human	PMID:26387950
Cellular Component	GO:0033106	cis-Golgi network membrane	PMEL	IDA		Human	PMID:15096515
Cellular Component	GO:0005783	endoplasmic reticulum	PMEL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005789	endoplasmic reticulum membrane	PMEL	IDA		Human	PMID:15096515
Cellular Component	GO:0005789	endoplasmic reticulum membrane	PMEL	IDA		Human	PMID:15695812
Cellular Component	GO:0070062	extracellular exosome	PMEL	IDA		Human	PMID:26387950
Cellular Component	GO:0005794	Golgi apparatus	PMEL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	PMEL	IDA		Human	PMID:15695812
Cellular Component	GO:0042470	melanosome	PMEL	IDA		Human	PMID:15695812
Cellular Component	GO:0042470	melanosome	PMEL	IDA		Human	PMID:26387950
Cellular Component	GO:0042470	melanosome	Pmel	IDA		Mouse	PMID:11266470
Cellular Component	GO:0033162	melanosome membrane	PMEL	IDA		Human	PMID:15096515
Cellular Component	GO:0033162	melanosome membrane	PMEL	IDA		Human	PMID:23754390
Cellular Component	GO:0032585	multivesicular body membrane	PMEL	IDA		Human	PMID:11694580
Cellular Component	GO:0097487	multivesicular body, internal vesicle	PMEL	IDA		Human	PMID:26387950
Biological Process	GO:1990000	amyloid fibril formation	pmela	IDA		Zfish	PMID:21148556
Biological Process	GO:0048066	developmental pigmentation	pmela	IMP	ZFIN:ZDB-GENO-120306-5	Zfish	PMID:9007256
Biological Process	GO:0048066	developmental pigmentation	pmela	IMP	ZFIN:ZDB-MRPHLNO-050912-1	Zfish	PMID:16024012
Biological Process	GO:0048066	developmental pigmentation	pmela	IMP	ZFIN:ZDB-GENO-980202-895	Zfish	PMID:16024012
Biological Process	GO:0048069	eye pigmentation	pmela	IMP	ZFIN:ZDB-MRPHLNO-050912-1	Zfish	PMID:16024012
Biological Process	GO:0048069	eye pigmentation	pmela	IMP	ZFIN:ZDB-GENO-980202-895	Zfish	PMID:16024012
Biological Process	GO:0042438	melanin biosynthetic process	Pmel	IMP	MGI:MGI:1857040	Mouse	PMID:7665913
Biological Process	GO:0030318	melanocyte differentiation	pmela	IMP	ZFIN:ZDB-MRPHLNO-181114-3	Zfish	PMID:30061422
Biological Process	GO:0032438	melanosome organization	PMEL	IDA		Human	PMID:11694580
Biological Process	GO:0032438	melanosome organization	pmela	IMP	ZFIN:ZDB-MRPHLNO-150618-3	Zfish	PMID:25690007
Biological Process	GO:0032438	melanosome organization	pmela	IGI	ZFIN:ZDB-MRPHLNO-150618-3,ZFIN:ZDB-MRPHLNO-150618-4	Zfish	PMID:25690007
Biological Process	GO:0032438	melanosome organization	pmelb	IGI	ZFIN:ZDB-MRPHLNO-150618-3,ZFIN:ZDB-MRPHLNO-150618-4	Zfish	PMID:25690007
Biological Process	GO:0048023	positive regulation of melanin biosynthetic process	Pmel	IMP		Mouse	MGI:MGI:5294257|PMID:21949658

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern