Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PML
  • Mouse genes Pml
  • Rat genes Pml
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pml

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q9UER7	Human	PMID:10669754
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:O35613	Human	PMID:10684855
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q13547	Human	PMID:11259576
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P63165	Human	PMID:11948183
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q96EB6	Human	PMID:12006491
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q9UER7	Human	PMID:12529400
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P04637	Human	PMID:12915590
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q00987	Human	PMID:12915590
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q9UER7	Human	PMID:14517282
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q99607	Human	PMID:14976184
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:A7UKY0	Human	PMID:15195100
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q9CXW4	Human	PMID:15195100
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q96EP1	Human	PMID:15467728
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P05412	Human	PMID:15626733
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P27958:PRO_0000037566	Human	PMID:16322229
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P68400	Human	PMID:16873060
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P42345	Human	PMID:16915281
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P63165	Human	PMID:17036045
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P14618	Human	PMID:18298799
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q15583	Human	PMID:18511908
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q9Y2M5	Human	PMID:20389280
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P68400	Human	PMID:20625391
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q8NEV1	Human	PMID:20625391
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P03243-1	Human	PMID:20639899
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q13164	Human	PMID:20832753
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P04637	Human	PMID:21057547
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P63165	Human	PMID:21057547
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P25445	Human	PMID:21803845
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q9UER7	Human	PMID:21840486
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q9Y2M5	Human	PMID:21840486
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P25788	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q08999	Human	PMID:22002537
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q13207	Human	PMID:22002537
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q16254	Human	PMID:22002537
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P43356	Human	PMID:22117195
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:O15055	Human	PMID:22274616
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q99497	Human	PMID:22683601
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q8UN00	Human	PMID:22685230
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q00987	Human	PMID:22869143
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q13164	Human	PMID:22869143
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q96T88	Human	PMID:22945642
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q9ULZ3	Human	PMID:24407287
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P04637	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P63165	Human	PMID:25497731
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:P03243-1	Human	PMID:25772236
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:G2XKQ0	Human	PMID:27211601
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:O75626	Human	PMID:28842558
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q6N021	Human	PMID:29735542
Molecular Function	GO:0005515	protein binding	PML	IPI	UniProtKB:Q05516	Human	PMID:9294197
Molecular Function	GO:0005515	protein binding	Pml	IPI	UniProtKB:Q505F1	Mouse	MGI:MGI:5919259|PMID:17187077
Molecular Function	GO:0005515	protein binding	Pml	IPI	UniProtKB:Q16236	Mouse	MGI:MGI:6212886|PMID:28777872
Molecular Function	GO:0005515	protein binding	Pml	IPI	UniProtKB:P25446	Mouse	MGI:MGI:5320263|PMID:21803845
Molecular Function	GO:0005515	protein binding	Pml	IPI	UniProtKB:P70227	Mouse	MGI:MGI:4849347|PMID:21030605
Molecular Function	GO:0005515	protein binding	Pml	IPI	UniProtKB:O54943	Mouse	MGI:MGI:5314433|PMID:22274616
Molecular Function	GO:0005515	protein binding	Pml	IPI	UniProtKB:Q8UN00	Mouse	MGI:MGI:5543889|PMID:22685230
Molecular Function	GO:0005515	protein binding	Pml	IPI	UniProtKB:Q14DJ8	Mouse	MGI:MGI:5315336|PMID:21057547
Molecular Function	GO:0005515	protein binding	Pml	IPI	UniProtKB:Q60979	Mouse	MGI:MGI:4397769|PMID:19745809
Molecular Function	GO:0005515	protein binding	Pml	IPI	PR:Q9JLN9	Mouse	PMID:16915281
Molecular Function	GO:0005515	protein binding	Pml	IPI	MGI:MGI:2652838	Mouse	PMID:15356634
Molecular Function	GO:0005515	protein binding	Pml	IPI	UniProtKB:Q9EPH0	Mouse	PMID:16915281
Molecular Function	GO:0005515	protein binding	Pml	IPI	UniProtKB:Q9EPH0	Mouse	PMID:15925207
Molecular Function	GO:0005515	protein binding	Pml	IPI	RefSeq:NP_110467	Mouse	PMID:12529400
Molecular Function	GO:0005515	protein binding	Pml	IPI	UniProtKB:P03243-1	Rat	PMID:20639899|RGD:8554484
Molecular Function	GO:0042803	protein homodimerization activity	PML	IPI	UniProtKB:P29590	Human	PMID:9230084
Molecular Function	GO:0046332	SMAD binding	Pml	IDA		Mouse	PMID:15356634
Molecular Function	GO:0032183	SUMO binding	PML	IPI	UniProtKB:P63165	Human	PMID:17081985
Molecular Function	GO:0019789	SUMO transferase activity	PML	EXP		Human	PMID:12393906
Molecular Function	GO:0019789	SUMO transferase activity	PML	EXP		Human	PMID:20972456
Molecular Function	GO:0140037	sumo-dependent protein binding	PML	IPI	UniProtKB:Q9UER7	Human	PMID:17081986
Molecular Function	GO:0031625	ubiquitin protein ligase binding	PML	IPI	UniProtKB:Q00987	Human	PMID:12915590
Cellular Component	GO:0000781	chromosome, telomeric region	PML	IDA		Human	PMID:26119943
Cellular Component	GO:0005737	cytoplasm	PML	IDA		Human	PMID:18298799
Cellular Component	GO:0005829	cytosol	Pml	IDA		Mouse	MGI:MGI:4849347|PMID:21030605
Cellular Component	GO:0042406	extrinsic component of endoplasmic reticulum membrane	Pml	IDA		Mouse	MGI:MGI:4849347|PMID:21030605
Cellular Component	GO:0000792	heterochromatin	Pml	IDA		Mouse	MGI:MGI:5882889|PMID:17081986
Cellular Component	GO:0016363	nuclear matrix	Pml	IDA		Mouse	PMID:15252119
Cellular Component	GO:0005730	nucleolus	PML	IDA		Human	PMID:15195100
Cellular Component	GO:0005654	nucleoplasm	PML	IDA		Human	PMID:12915590
Cellular Component	GO:0005634	nucleus	PML	IDA		Human	PMID:22274616
Cellular Component	GO:0005634	nucleus	PML	IDA		Human	PMID:9412458
Cellular Component	GO:0005634	nucleus	Pml	IDA		Mouse	MGI:MGI:4849347|PMID:21030605
Cellular Component	GO:0005634	nucleus	Pml	IDA		Mouse	MGI:MGI:5314433|PMID:22274616
Cellular Component	GO:0005634	nucleus	Pml	IDA		Mouse	MGI:MGI:5882889|PMID:17081986
Cellular Component	GO:0005634	nucleus	Pml	IDA		Mouse	PMID:19416967
Cellular Component	GO:0005634	nucleus	Pml	IDA		Mouse	PMID:10716735
Cellular Component	GO:0005634	nucleus	Pml	IDA		Rat	PMID:17289031|RGD:9587773
Cellular Component	GO:0016605	PML body	PML	IDA		Human	PMID:10910364
Cellular Component	GO:0016605	PML body	PML	IDA		Human	PMID:11331580
Cellular Component	GO:0016605	PML body	PML	IDA		Human	PMID:12917339
Cellular Component	GO:0016605	PML body	PML	IDA		Human	PMID:15195100
Cellular Component	GO:0016605	PML body	PML	IDA		Human	PMID:17081985
Cellular Component	GO:0016605	PML body	PML	IDA		Human	PMID:22155184
Cellular Component	GO:0016605	PML body	PML	IDA		Human	PMID:22869143
Cellular Component	GO:0016605	PML body	PML	IDA		Human	PMID:23007646
Cellular Component	GO:0016605	PML body	PML	IDA		Human	PMID:23431171
Cellular Component	GO:0016605	PML body	PML	IDA		Human	PMID:9412458
Cellular Component	GO:0016605	PML body	PML	IDA		Human	PMID:9448006
Cellular Component	GO:0016605	PML body	Pml	IMP		Mouse	MGI:MGI:3717519|PMID:10779416
Cellular Component	GO:0016605	PML body	Pml	IDA		Mouse	PMID:22904064
Cellular Component	GO:0016605	PML body	Pml	IDA		Mouse	PMID:16461359
Cellular Component	GO:0016605	PML body	Pml	IDA		Mouse	PMID:19033381
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:9806545
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:19261859
Biological Process	GO:0045165	cell fate commitment	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:19261859
Biological Process	GO:0071353	cellular response to interleukin-4	Pml	IDA		Mouse	PMID:9798653
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Pml	IEP		Mouse	PMID:20439489
Biological Process	GO:0090398	cellular senescence	PML	IDA		Human	PMID:22002537
Biological Process	GO:0090398	cellular senescence	PML	IDA		Human	PMID:22117195
Biological Process	GO:0090398	cellular senescence	PML	IDA		Human	PMID:23431171
Biological Process	GO:0032922	circadian regulation of gene expression	Pml	IDA		Mouse	MGI:MGI:5314433|PMID:22274616
Biological Process	GO:0007182	common-partner SMAD protein phosphorylation	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:15356634
Biological Process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Pml	IMP		Mouse	MGI:MGI:3580934|PMID:15626733
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Pml	IMP		Mouse	MGI:MGI:4849347|PMID:21030605
Biological Process	GO:0043153	entrainment of circadian clock by photoperiod	Pml	IDA		Mouse	MGI:MGI:5314433|PMID:22274616
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:9806545
Biological Process	GO:0010761	fibroblast migration	Pml	IMP		Mouse	MGI:MGI:5502477|PMID:23555679
Biological Process	GO:0045087	innate immune response	PML	IDA		Human	PMID:18248090
Biological Process	GO:0045087	innate immune response	Pml	IDA		Mouse	MGI:MGI:5545996|PMID:18248090
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	Pml	IMP		Mouse	PMID:14992722
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:9806545
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Pml	IMP	MGI:MGI:104662	Mouse	PMID:15626733
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Pml	IMP		Mouse	MGI:MGI:3580934|PMID:15626733
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Pml	IMP		Mouse	PMID:21030605
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Pml	IMP		Mouse	PMID:21030605
Biological Process	GO:0051457	maintenance of protein location in nucleus	PML	IDA		Human	PMID:17332504
Biological Process	GO:0030099	myeloid cell differentiation	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:9488655
Biological Process	GO:0016525	negative regulation of angiogenesis	PML	IMP		Human	PMID:16915281
Biological Process	GO:0016525	negative regulation of angiogenesis	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:16915281
Biological Process	GO:0030308	negative regulation of cell growth	PML	IDA		Human	PMID:9448006
Biological Process	GO:0008285	negative regulation of cell population proliferation	PML	IMP		Human	PMID:12006491
Biological Process	GO:0008285	negative regulation of cell population proliferation	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:9488655
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PML	IDA		Human	PMID:9448006
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	Pml	IMP		Mouse	MGI:MGI:5621259|PMID:24407287
Biological Process	GO:0032692	negative regulation of interleukin-1 production	Pml	IMP		Mouse	MGI:MGI:5621259|PMID:24407287
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	PML	IMP		Human	PMID:15195100
Biological Process	GO:0090402	oncogene-induced cell senescence	Pml	IMP		Mouse	MGI:MGI:3717518|PMID:10910364
Biological Process	GO:0030578	PML body organization	PML	IMP		Human	PMID:17081985
Biological Process	GO:0030578	PML body organization	Pml	IDA		Mouse	PMID:12529400
Biological Process	GO:0030578	PML body organization	Pml	IMP		Rat	PMID:17289031|RGD:9587773
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Pml	IGI	MGI:MGI:1197015	Mouse	PMID:10684855
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Pml	IMP		Mouse	PMID:10684855
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	PML	IMP		Human	PMID:21803845
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Pml	IMP		Mouse	MGI:MGI:5502477|PMID:23555679
Biological Process	GO:2000758	positive regulation of peptidyl-lysine acetylation	Pml	IMP		Mouse	MGI:MGI:3717518|PMID:10910364
Biological Process	GO:1901798	positive regulation of signal transduction by p53 class mediator	Pml	IMP		Mouse	MGI:MGI:3717518|PMID:10910364
Biological Process	GO:0032206	positive regulation of telomere maintenance	PML	IMP		Human	PMID:26119943
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PML	IDA		Human	PMID:22406621
Biological Process	GO:0006606	protein import into nucleus	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:15356634
Biological Process	GO:0065003	protein-containing complex assembly	PML	IDA		Human	PMID:12915590
Biological Process	GO:0031503	protein-containing complex localization	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:15356634
Biological Process	GO:0010522	regulation of calcium ion transport into cytosol	Pml	IMP		Mouse	MGI:MGI:4849347|PMID:21030605
Biological Process	GO:0030155	regulation of cell adhesion	Pml	IMP		Mouse	MGI:MGI:5502477|PMID:23555679
Biological Process	GO:0042752	regulation of circadian rhythm	Pml	IDA		Mouse	MGI:MGI:5314433|PMID:22274616
Biological Process	GO:0006355	regulation of DNA-templated transcription	PML	IMP		Human	PMID:23007646
Biological Process	GO:2000779	regulation of double-strand break repair	PML	IMP		Human	PMID:21639834
Biological Process	GO:0034097	response to cytokine	PML	IDA		Human	PMID:9412458
Biological Process	GO:0010332	response to gamma radiation	Pml	IMP	MGI:MGI:104662	Mouse	PMID:11025664
Biological Process	GO:0010332	response to gamma radiation	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:9806545
Biological Process	GO:0001666	response to hypoxia	PML	IDA		Human	PMID:16915281
Biological Process	GO:0001666	response to hypoxia	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:16915281
Biological Process	GO:0009411	response to UV	Pml	IMP	MGI:MGI:104662	Mouse	PMID:15626733
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:9488655
Biological Process	GO:0044790	suppression of viral release by host	PML	IDA		Human	PMID:18248090
Biological Process	GO:0044790	suppression of viral release by host	Pml	IDA		Mouse	MGI:MGI:5545996|PMID:18248090
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Pml	IMP	MGI:MGI:2429949	Mouse	PMID:15356634

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern