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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pmp22

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pmp22
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003774cytoskeletal motor activityPmp22IMPMousePMID:28108290
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q99572HumanPMID:12107182
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P40855HumanPMID:14709540
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P26715HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9BZL3HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:O43889-2HumanPMID:25910212
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9BZL3HumanPMID:25910212
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:O00501HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:O15173HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:O15529HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:O15552HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:O15554HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:O75787HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:O95236-2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:O95859HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P07307-3HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P09693HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P19397HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P26715HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P27105HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P31431HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P35372-10HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P38484HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P40198HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P41181HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P48051HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P48165HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P54219-3HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P54849HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P55899HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P56747HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P56856HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:P60508HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q07108HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q13113HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q15125HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q16585HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q2HXU8-2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q3MIR4HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q3SXP7HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q3SXY8HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q5JX71HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q6UWD8HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q86T13HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q8IV31HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q8N9I0HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q92838HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q96BA8HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q96CE8HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q96DZ7HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q96HE8HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q96MV1HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9BZJ8HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9BZL3HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9GZW8HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9H2H9HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9H3N1HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9H6H4HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9HBV2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9NUH8HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9NY72HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9NZD1HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q9Y282HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingPMP22IPIUniProtKB:Q8WXH2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingPmp22IPIPR:A2A863MousePMID:29315582
Molecular FunctionGO:0005515protein bindingPmp22IPIPR:A2A863MousePMID:16436605
Molecular FunctionGO:0005515protein bindingPmp22IPIPR:P09803MousePMID:27583434
Molecular FunctionGO:0005515protein bindingPmp22IPIPR:Q61739MousePMID:16436605
Cellular ComponentGO:0005923bicellular tight junctionPmp22IDARatPMID:11717414|RGD:70581
Cellular ComponentGO:0009986cell surfacePmp22IDAMousePMID:16436605
Cellular ComponentGO:0043218compact myelinPmp22IDAMousePMID:11114256
Cellular ComponentGO:0043218compact myelinPmp22IDAMousePMID:29315582
Cellular ComponentGO:0043218compact myelinPmp22IDARatPMID:1556154|RGD:1358785
Cellular ComponentGO:0008305integrin complexPmp22IDAMousePMID:16436605
Cellular ComponentGO:0043256laminin complexPmp22IDAMousePMID:16436605
Cellular ComponentGO:0016020membranePmp22IDAMousePMID:12359155
Cellular ComponentGO:0016020membranePmp22IDARatPMID:11717414|RGD:70581
Cellular ComponentGO:0048471perinuclear region of cytoplasmPmp22IDAMousePMID:12359155
Cellular ComponentGO:0005886plasma membranePMP22IDAHumanPMID:12107182
Biological ProcessGO:0030036actin cytoskeleton organizationPmp22IMPMGI:MGI:2447704MousePMID:27583434
Biological ProcessGO:0030036actin cytoskeleton organizationPmp22IMPMGI:MGI:3614822MousePMID:25429154
Biological ProcessGO:0008344adult locomotory behaviorPmp22IMPMGI:MGI:2388488MousePMID:12359155
Biological ProcessGO:0008344adult locomotory behaviorPmp22IMPMGI:MGI:1862011MousePMID:12359155
Biological ProcessGO:0008344adult locomotory behaviorPmp22IMPMGI:MGI:1856217MousePMID:25014022
Biological ProcessGO:0008344adult locomotory behaviorPmp22IMPMGI:MGI:1862010MousePMID:12359155
Biological ProcessGO:0007628adult walking behaviorPmp22IMPMGI:MGI:1862010MousePMID:12359155
Biological ProcessGO:0007628adult walking behaviorPmp22IMPMGI:MGI:1862011MousePMID:12359155
Biological ProcessGO:0007628adult walking behaviorPmp22IMPMGI:MGI:2388488MousePMID:12359155
Biological ProcessGO:0070842aggresome assemblyPmp22IMPMGI:MGI:1856217MousePMID:15748170
Biological ProcessGO:0006914autophagyPmp22IMPMGI:MGI:1856217MousePMID:25014022
Biological ProcessGO:0006914autophagyPmp22IMPMGI:MGI:2447704MousePMID:14627652
Biological ProcessGO:0006914autophagyPmp22IMPMGI:MGI:1856217MousePMID:17174099
Biological ProcessGO:0061564axon developmentPmp22IMPMGI:MGI:2447704MousePMID:20071523
Biological ProcessGO:0071711basement membrane organizationPmp22IMPMGI:MGI:3614822MousePMID:16436605
Biological ProcessGO:0032060bleb assemblyPMP22IDAHumanPMID:12107182
Biological ProcessGO:0007155cell adhesionPmp22IMPMGI:MGI:3614822MousePMID:25429154
Biological ProcessGO:0008219cell deathPMP22IDAHumanPMID:12107182
Biological ProcessGO:0030154cell differentiationPmp22IDARatPMID:11456309|RGD:729622
Biological ProcessGO:0044255cellular lipid metabolic processPmp22IMPMGI:MGI:2447704MousePMID:22337502
Biological ProcessGO:0051641cellular localizationPmp22IMPMGI:MGI:1856217MousePMID:15703401
Biological ProcessGO:0034605cellular response to heatPmp22IMPMGI:MGI:1856217MousePMID:23847051
Biological ProcessGO:0034620cellular response to unfolded proteinPmp22IMPGO:0034620MousePMID:23847051
Biological ProcessGO:0008203cholesterol metabolic processPmp22IMPMGI:MGI:3614822MousePMID:25429154
Biological ProcessGO:0010761fibroblast migrationPmp22IMPMGI:MGI:3614822MousePMID:25429154
Biological ProcessGO:0042063gliogenesisPmp22IMPMGI:MGI:2447704MousePMID:14627652
Biological ProcessGO:0006955immune responsePmp22IMPMGI:MGI:2447704MousePMID:22337502
Biological ProcessGO:0030032lamellipodium assemblyPmp22IMPMGI:MGI:3614822MousePMID:25429154
Biological ProcessGO:0007618matingPmp22IMPMGI:MGI:3614822MousePMID:16436605
Biological ProcessGO:0031579membrane raft organizationPmp22IMPMGI:MGI:3614822MousePMID:17971504
Biological ProcessGO:0061744motor behaviorPmp22IMPMGI:MGI:1862010MousePMID:12359155
Biological ProcessGO:0061744motor behaviorPmp22IMPMGI:MGI:1862011MousePMID:12359155
Biological ProcessGO:0061744motor behaviorPmp22IMPMGI:MGI:2388488MousePMID:12359155
Biological ProcessGO:0061744motor behaviorPmp22IMPMGI:MGI:3614822MousePMID:16436605
Biological ProcessGO:0035264multicellular organism growthPmp22IMPMGI:MGI:3614822MousePMID:16436605
Biological ProcessGO:0055001muscle cell developmentPmp22IMPMousePMID:28108290
Biological ProcessGO:0032288myelin assemblyPmp22IMPMGI:MGI:1856217MousePMID:25453108
Biological ProcessGO:0032288myelin assemblyPmp22IMPMGI:MGI:1856217MousePMID:20427655
Biological ProcessGO:0032288myelin assemblyPmp22IMPMGI:MGI:2447704MousePMID:20071523
Biological ProcessGO:0032288myelin assemblyPmp22IMPMGI:MGI:2447704MousePMID:27583434
Biological ProcessGO:0032288myelin assemblyPmp22IMPMGI:MGI:1856420MousePMID:16405874
Biological ProcessGO:0042552myelinationPmp22IMPMGI:MGI:2447704MousePMID:20731761
Biological ProcessGO:0042552myelinationPmp22IMPMousePMID:28108290
Biological ProcessGO:0042552myelinationPmp22IDARatPMID:11456309|RGD:729622
Biological ProcessGO:0042552myelinationPmp22IMPRatPMID:11456309|RGD:729622
Biological ProcessGO:0022011myelination in peripheral nervous systemPmp22IGIMGI:MGI:96613MousePMID:29315582
Biological ProcessGO:0022011myelination in peripheral nervous systemPmp22IMPMGI:MGI:1856217MousePMID:20553714
Biological ProcessGO:0022011myelination in peripheral nervous systemPmp22IMPMGI:MGI:2447704MousePMID:22337502
Biological ProcessGO:0022011myelination in peripheral nervous systemPmp22IGIMGI:MGI:97385MousePMID:20553714
Biological ProcessGO:0022011myelination in peripheral nervous systemPmp22IGIMGI:MGI:97384MousePMID:20553714
Biological ProcessGO:0022011myelination in peripheral nervous systemPmp22IMPMGI:MGI:2388488MousePMID:12359155
Biological ProcessGO:0022011myelination in peripheral nervous systemPmp22IMPMGI:MGI:1856217MousePMID:25014022
Biological ProcessGO:0022011myelination in peripheral nervous systemPmp22IMPMGI:MGI:3614822MousePMID:16436605
Biological ProcessGO:0022011myelination in peripheral nervous systemPmp22IMPMGI:MGI:1856217MousePMID:25453108
Biological ProcessGO:0022011myelination in peripheral nervous systemPmp22IMPMGI:MGI:3614822MousePMID:25429154
Biological ProcessGO:0008285negative regulation of cell population proliferationPmp22IDARatPMID:11519720|RGD:8554002
Biological ProcessGO:0008285negative regulation of cell population proliferationPmp22IMPRatPMID:7720703|RGD:1358784
Biological ProcessGO:0010629negative regulation of gene expressionPmp22IMPMGI:MGI:1856217MousePMID:23847051
Biological ProcessGO:0010977negative regulation of neuron projection developmentPmp22IDARatPMID:11519720|RGD:8554002
Biological ProcessGO:0098529neuromuscular junction development, skeletal muscle fiberPmp22IMPMGI:MGI:1856217MousePMID:25014022
Biological ProcessGO:0050905neuromuscular processPmp22IMPMGI:MGI:2388488MousePMID:12359155
Biological ProcessGO:0019228neuronal action potentialPmp22IMPMGI:MGI:2447704MousePMID:27583434
Biological ProcessGO:0019227neuronal action potential propagationPmp22IMPMGI:MGI:2447704MousePMID:20071523
Biological ProcessGO:0045161neuronal ion channel clusteringPmp22IMPMGI:MGI:1856217MousePMID:15703401
Biological ProcessGO:0030913paranodal junction assemblyPmp22IMPMGI:MGI:3614822MousePMID:16436605
Biological ProcessGO:0007422peripheral nervous system developmentPmp22IMPMGI:MGI:3614822MousePMID:16436605
Biological ProcessGO:0007422peripheral nervous system developmentPmp22IMPMGI:MGI:2447704MousePMID:22337502
Biological ProcessGO:0007422peripheral nervous system developmentPmp22IMPMousePMID:2022965
Biological ProcessGO:0048936peripheral nervous system neuron axonogenesisPmp22IMPMGI:MGI:1856217MousePMID:25014022
Biological ProcessGO:0048936peripheral nervous system neuron axonogenesisPmp22IMPMGI:MGI:1862010MousePMID:12359155
Biological ProcessGO:0048936peripheral nervous system neuron axonogenesisPmp22IMPMGI:MGI:1862011MousePMID:12359155
Biological ProcessGO:0048936peripheral nervous system neuron axonogenesisPmp22IMPMGI:MGI:2388488MousePMID:12359155
Biological ProcessGO:0010628positive regulation of gene expressionPmp22IMPMGI:MGI:3614822MousePMID:16436605
Biological ProcessGO:0010498proteasomal protein catabolic processPmp22IMPMGI:MGI:2447704MousePMID:14627652
Biological ProcessGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic processPmp22IMPMGI:MGI:1856217MousePMID:15748170
Biological ProcessGO:2001233regulation of apoptotic signaling pathwayPmp22IMPMGI:MGI:1856217MousePMID:23847051
Biological ProcessGO:0010468regulation of gene expressionPmp22IMPMGI:MGI:3614822MousePMID:25429154
Biological ProcessGO:0010468regulation of gene expressionPmp22IMPMousePMID:28108290
Biological ProcessGO:0034350regulation of glial cell apoptotic processPmp22IMPMGI:MGI:2447704MousePMID:11673320
Biological ProcessGO:0050727regulation of inflammatory responsePmp22IMPMGI:MGI:1856217MousePMID:23847051
Biological ProcessGO:0071900regulation of protein serine/threonine kinase activityPmp22IMPMGI:MGI:2447704MousePMID:27583434
Biological ProcessGO:0010624regulation of Schwann cell proliferationPmp22IMPMGI:MGI:2447704MousePMID:11673320
Biological ProcessGO:0009617response to bacteriumPmp22IEPMousePMID:23012479
Biological ProcessGO:0034976response to endoplasmic reticulum stressPmp22IMPMGI:MGI:1856217MousePMID:23847051
Biological ProcessGO:0014044Schwann cell developmentPmp22IMPMGI:MGI:3614822MousePMID:25429154
Biological ProcessGO:0014037Schwann cell differentiationPmp22IMPMousePMID:28108290
Biological ProcessGO:0014037Schwann cell differentiationPmp22IMPMGI:MGI:2447704MousePMID:25150498
Biological ProcessGO:0014037Schwann cell differentiationPmp22IMPMGI:MGI:1856217MousePMID:15748170
Biological ProcessGO:0014037Schwann cell differentiationPmp22IMPMGI:MGI:2447704MousePMID:14627652
Biological ProcessGO:0036135Schwann cell migrationPmp22IMPMGI:MGI:3614822MousePMID:25429154
Biological ProcessGO:0051146striated muscle cell differentiationPmp22IMPMGI:MGI:3614822MousePMID:16436605
Biological ProcessGO:0019226transmission of nerve impulsePmp22IGIMGI:MGI:1339975MousePMID:27583434
Biological ProcessGO:0019226transmission of nerve impulsePmp22IMPMousePMID:28108290
Biological ProcessGO:0019226transmission of nerve impulsePmp22IGIMGI:MGI:96613MousePMID:29315582
Biological ProcessGO:0019226transmission of nerve impulsePmp22IGIMGI:MGI:97384MousePMID:20553714
Biological ProcessGO:0019226transmission of nerve impulsePmp22IGIMGI:MGI:97385MousePMID:20553714
Biological ProcessGO:0019226transmission of nerve impulsePmp22IMPMGI:MGI:1856217MousePMID:15363066
Biological ProcessGO:0019226transmission of nerve impulsePmp22IMPMGI:MGI:2447704MousePMID:20071523
Biological ProcessGO:0060005vestibular reflexPmp22IMPMGI:MGI:1862010MousePMID:12359155
Biological ProcessGO:0060005vestibular reflexPmp22IMPMGI:MGI:1862011MousePMID:12359155
Biological ProcessGO:0060005vestibular reflexPmp22IMPMGI:MGI:2388488MousePMID:12359155

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory