Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PMVK
  • Mouse genes Pmvk
  • Rat genes Pmvk
  • Zfish genes pmvk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pmvk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	PMVK	IDA		Human	PMID:16519518
Molecular Function	GO:0004631	phosphomevalonate kinase activity	PMVK	IDA		Human	PMID:14680974
Molecular Function	GO:0004631	phosphomevalonate kinase activity	PMVK	IDA		Human	PMID:16519518
Molecular Function	GO:0004631	phosphomevalonate kinase activity	PMVK	IDA		Human	PMID:8663599
Molecular Function	GO:0004631	phosphomevalonate kinase activity	Pmvk	IDA		Mouse	PMID:11792727
Molecular Function	GO:0004631	phosphomevalonate kinase activity	Pmvk	IDA		Rat	PMID:197206|RGD:2316852
Molecular Function	GO:0005515	protein binding	PMVK	IPI	UniProtKB:Q13360-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PMVK	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Cellular Component	GO:0005829	cytosol	PMVK	IDA		Human	PMID:14729858
Cellular Component	GO:0005829	cytosol	PMVK	IDA		Human	PMID:27052676
Cellular Component	GO:0070062	extracellular exosome	PMVK	HDA		Human	PMID:19056867
Cellular Component	GO:0016020	membrane	PMVK	HDA		Human	PMID:19946888
Cellular Component	GO:0005777	peroxisome	PMVK	IDA		Human	PMID:17180682
Biological Process	GO:0006695	cholesterol biosynthetic process	PMVK	IDA		Human	PMID:8663599
Biological Process	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	Pmvk	IDA		Rat	PMID:197206|RGD:2316852
Biological Process	GO:0070723	response to cholesterol	PMVK	IEP		Human	PMID:10191291
Biological Process	GO:0016126	sterol biosynthetic process	PMVK	IDA		Human	PMID:16519518

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern