Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PNKP
  • Mouse genes Pnkp
  • Rat genes Pnkp
  • Zfish genes pnkp
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pnkp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046404	polydeoxyribonucleotide 5'-hydroxyl-kinase activity	PNKP	IDA		Human	PMID:10446193
Molecular Function	GO:0046403	polynucleotide 3'-phosphatase activity	PNKP	IDA		Human	PMID:10446192
Molecular Function	GO:0046403	polynucleotide 3'-phosphatase activity	PNKP	IDA		Human	PMID:10446193
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q13426	Human	PMID:15385968
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:O94972	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:P18887	Human	PMID:19155274
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:P18887	Human	PMID:21637298
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q13426	Human	PMID:21637298
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:O43829	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q13422	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q15025	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q9UID6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:O43524	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:P18887	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q13426	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:O43586	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:O43759-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:O43761	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:O43829	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:O60749	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:O94972	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:O95995	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:P08247	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:P23508	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q02446	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q13422-7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q13426	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q13554-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q15025	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q15633	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q49A88-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q53G59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q63ZY3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q86TI0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q86WV7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q8N137	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q8N5K1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q8N9I5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q8NCY6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q8WV19	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q8WW34-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q92997	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q96PV4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q99735	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q9BWT7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q9NS64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q9NVV9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q9UGQ2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q9UID6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q9UMD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:P28329-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PNKP	IPI	UniProtKB:Q9UMX0	Human	PMID:32814053
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	Pnkp	IDA		Mouse	MGI:MGI:5780352|PMID:26774286
Cellular Component	GO:0016020	membrane	PNKP	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	Pnkp	IDA		Rat	PMID:22210862|RGD:8693578
Cellular Component	GO:0005730	nucleolus	PNKP	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PNKP	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PNKP	IDA		Human	PMID:10446193
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	Pnkp	IDA		Mouse	MGI:MGI:5780352|PMID:26774286
Cellular Component	GO:0035861	site of double-strand break	PNKP	IDA		Human	PMID:28453785
Cellular Component	GO:0035861	site of double-strand break	Pnkp	IDA		Mouse	MGI:MGI:5780352|PMID:26774286
Biological Process	GO:0006974	DNA damage response	Pnkp	IDA		Mouse	MGI:MGI:5780352|PMID:26774286
Biological Process	GO:0051103	DNA ligation involved in DNA repair	PNKP	IDA		Human	PMID:15385968
Biological Process	GO:0006281	DNA repair	PNKP	IGI	UniProtKB:J7Q8E6,UniProtKB:J7QRV0	Human	PMID:10446192
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	PNKP	IDA		Human	PMID:15385968
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	PNKP	IDA		Human	PMID:28453785
Biological Process	GO:0010836	negative regulation of protein ADP-ribosylation	PNKP	IMP		Human	PMID:28002403
Biological Process	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	PNKP	IMP		Human	PMID:12032095
Biological Process	GO:0051973	positive regulation of telomerase activity	PNKP	IMP		Human	PMID:21531765
Biological Process	GO:1904355	positive regulation of telomere capping	PNKP	IMP		Human	PMID:21531765
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	PNKP	IMP		Human	PMID:21531765
Biological Process	GO:0070534	protein K63-linked ubiquitination	Pnkp	IDA		Mouse	MGI:MGI:5780352|PMID:26774286
Biological Process	GO:0006979	response to oxidative stress	PNKP	IDA		Human	PMID:10446192

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern